The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis
Open accessAbstract
Plant recognition of pathogens leads to rapid activation of MPK3 and MPK6, two Arabidopsis mitogen-activated protein kinases (MAPKs), and their orthologs in other species. Here, we report that synthesis of camalexin, the major phytoalexin in Arabidopsis , is regulated by the MPK3/MPK6 cascade. Activation of MPK3/MPK6 by expression of active upstream MAPK kinase (MAPKK) or MAPKK kinase (MAPKKK) was sufficient to induce camalexin synthesis in the absence of pathogen attack. Induction of camalexin by Botrytis cinerea was preceded by MPK3/MPK6 activation, and compromised in mpk3 and mpk6 mutants. Genetic analysis placed the MPK3/MPK6 cascade upstream of PHYTOALEXIN DEFICIENT 2 (PAD2) and PAD3, but independent or downstream of PAD1 and PAD4. Camalexin induction after MPK3/MPK6 activation was preceded by rapid and coordinated up-regulation of multiple genes encoding enzymes in the tryptophan (Trp) biosynthetic pathway, in the conversion of Trp to indole-3-acetaldoxime (IAOx, a branch point between primary and secondary metabolism), and in the camalexin biosynthetic pathway downstream of IAOx. These results indicate that the MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Plant pathogens and integrated defence responses to infection
Dangl, J. L., & Jones, J. D. G. (2001) · Nature · doi:10.1038/35081161 · Cited by 3,949
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
WIDMANN, C., GIBSON, S., JARPE, M. B., & JOHNSON, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,729
MAP kinase signalling cascade in Arabidopsis innate immunity
Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W.-L., Gomez-Gomez, L., Boller, T., Ausubel, F. M., & Sheen, J. (2002) · Nature · doi:10.1038/415977a · Cited by 2,726
Natural products and plant disease resistance
Dixon, R. A. (2001) · Nature · doi:10.1038/35081178 · Cited by 1,790
Botrytis cinerea : the cause of grey mould disease
WILLIAMSON, B., TUDZYNSKI, B., TUDZYNSKI, P., & VAN KAN, J. A. L. (2007) · Molecular Plant Pathology · doi:10.1111/j.1364-3703.2007.00417.x · Cited by 1,729
Mitogen-activated protein kinase cascades in plants: a new nomenclature
(Kazuya Ichimura et al.), M. G., Ichimura, K., Shinozaki, K., Tena, G., Sheen, J., Henry, Y., Champion, A., Kreis, M., Zhang, S., Hirt, H., et al. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02302-6 · Cited by 1,259
Self-citationArabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance
Petersen, M., Brodersen, P., Naested, H., Andreasson, E., Lindhart, U., Johansen, B., Nielsen, H. B., Lacy, M., Austin, M. J., Parker, J. E., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00213-0 · Cited by 1,035
Are innate immune signaling pathways in plants and animals conserved?
Ausubel, F. M. (2005) · Nature Immunology · doi:10.1038/ni1253 · Cited by 976
Molecular Genetics of Plant Disease Resistance
Staskawicz, B. J., Ausubel, F. M., Baker, B. J., Ellis, J. G., & Jones, J. D. G. (1995) · Science · doi:10.1126/science.7732374 · Cited by 914
Liu, Y., & Zhang, S. (2004) · The Plant Cell · doi:10.1105/tpc.104.026609 · Cited by 863
Self-citation
Cited by
MAPK Cascades in Plant Disease Resistance Signaling
Meng, X., & Zhang, S. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102314 · Cited by 1,367
Self-citationMAPK cascade signalling networks in plant defence
Pitzschke, A., Schikora, A., & Hirt, H. (2009) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2009.06.008 · Cited by 710
Mitogen‐activated protein kinase cascades in plant signaling
Zhang, M., & Zhang, S. (2022) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13215 · Cited by 599
Self-citationMengiste, T. (2012) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-081211-172955 · Cited by 566
Transcriptional networks in plant immunity
Tsuda, K., & Somssich, I. E. (2015) · New Phytologist · doi:10.1111/nph.13286 · Cited by 552
Metadata
- Authors
- Ren, D., Liu, Y., Yang, K.-Y., Han, L., Mao, G., Glazebrook, J., & Zhang, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-04-08
- Volume
- 105
- Issue
- 14
- Pages
- 5638-5643
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077328940
- Cited by
- 354
- References
- 38
- FWCI
- 25.45
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis. https://app.cochat.ai/papers/10.1073/pnas.0711301105
- The paper
- Ren, D., Liu, Y., Yang, K.-Y., Han, L., Mao, G., Glazebrook, J., & Zhang, S. (2008). A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0711301105
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
