The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Comparative lesion sequencing provides insights into tumor evolution
Open accessAbstract
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: ( i ) It takes ≈17 years for a large benign tumor to evolve into an advanced cancer but <2 years for cells within that cancer to acquire the ability to metastasize; ( ii ) it requires few, if any, selective events to transform a highly invasive cancer cell into one with the capacity to metastasize; ( iii ) the process of cell culture ex vivo does not introduce new clonal mutations into colorectal tumor cell populations; and ( iv ) the rates at which point mutations develop in advanced cancers are similar to those of normal cells. These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis.
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Self-citationCancer genes and the pathways they control
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Self-citationThe Consensus Coding Sequences of Human Breast and Colorectal Cancers
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Cited by
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863
Self-citationAn Integrated Genomic Analysis of Human Glioblastoma Multiforme
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Self-citationTumor Metastasis: Molecular Insights and Evolving Paradigms
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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
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Metadata
- Authors
- Jones, S., Chen, W.-D., Parmigiani, G., Diehl, F., Beerenwinkel, N., Antal, T., Traulsen, A., Nowak, M. A., Siegel, C., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Willis, J., & Markowitz, S. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-03-18
- Volume
- 105
- Issue
- 11
- Pages
- 4283-4288
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2163235555
- Cited by
- 818
- References
- 49
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Jones, S., Chen, W.-D., Parmigiani, G., Diehl, F., Beerenwinkel, N., Antal, T., Traulsen, A., Nowak, M. A., Siegel, C., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Willis, J., & Markowitz, S. D. (2008). Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0712345105
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