Tumor Metastasis: Molecular Insights and Evolving Paradigms
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Metastases represent the end-products of a multi-step cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by (1) acquisition of genetic and/or epigenetic alterations within tumor cells and (2) co-option of non-neoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances have provided provocative insights regarding these cell-biological and molecular changes, which carry implications concerning the pathogenesis of metastatic progression and the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting.
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- Authors
- Valastyan, S., & Weinberg, R. A.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Valastyan, Scott
- Weinberg, Robert A.
- ORCID
- Weinberg, Robert A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 147
- Issue
- 2
- Pages
- 275-292
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3261217
- OpenAlex
- W2165200432
- Semantic Scholar
- 0445241536ac8f898f016d0c93d9e513e3d1a475
- Cited by
- 4,011
- References
- 112
- Citations by year
- 2026: 151 · 2025: 200 · 2024: 310 · 2023: 287 · 2022: 346 · 2021: 371 · 2020: 342 · 2019: 318 · 2018: 300 · 2017: 296 · 2016: 292 · 2015: 268 · 2014: 217 · 2013: 193 · 2012: 108
- FWCI
- 14.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Elsevier eBooks
- Funders
- National Cancer Institute (P01CA080111, R01CA078461)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- metastasis, invasion-metastasis cascade, cancer cell dissemination, tumor microenvironment adaptation, epigenetic modifications, genetic alterations
- MeSH terms
- Animals, Basement Membrane, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Prognosis, Signal Transduction, Stromal Cells
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