Cited by 4,011Cancer Cells and MetastasisMechanisms of cancer metastasisProtease and Inhibitor Mechanisms

Tumor Metastasis: Molecular Insights and Evolving Paradigms

Open access
Valastyan, Scott, Weinberg, Robert A.·2011·Cell

Abstract

Metastases represent the end-products of a multi-step cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by (1) acquisition of genetic and/or epigenetic alterations within tumor cells and (2) co-option of non-neoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances have provided provocative insights regarding these cell-biological and molecular changes, which carry implications concerning the pathogenesis of metastatic progression and the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting.

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Crossref · 10.1016/j.cell.2011.09.024

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Authors
Valastyan, S., & Weinberg, R. A.
Affiliations
Whitehead Institute for Biomedical Research (US)
Corresponding author
  • Valastyan, Scott
  • Weinberg, Robert A.
Venue
Cell
Publisher
Elsevier BV
Published
2011-10
Volume
147
Issue
2
Pages
275-292
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2165200432
Cited by
4,011
References
112
Citations by year
2026: 151 · 2025: 200 · 2024: 310 · 2023: 287 · 2022: 346 · 2021: 371 · 2020: 342 · 2019: 318 · 2018: 300 · 2017: 296 · 2016: 292 · 2015: 268 · 2014: 217 · 2013: 193 · 2012: 108
FWCI
14.74
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
  • Elsevier eBooks
Funders
National Cancer Institute (P01CA080111, R01CA078461)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
metastasis, invasion-metastasis cascade, cancer cell dissemination, tumor microenvironment adaptation, epigenetic modifications, genetic alterations
MeSH terms
Animals, Basement Membrane, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Prognosis, Signal Transduction, Stromal Cells

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