The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Sialylation is essential for early development in mice
Open accessAbstract
Sialic acids are widely expressed as terminal carbohydrates on glycoconjugates of eukaryotic cells. Sialylation is crucial for a variety of cellular functions, such as cell adhesion or signal recognition, and regulates the biological stability of glycoproteins. The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc 2-epimerase), which catalyzes the first two steps of sialic acid biosynthesis in the cytosol. We report that inactivation of the UDP-GlcNAc 2-epimerase by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development. The need of UDP-GlcNAc 2-epimerase for a defined sialylation process is exemplified with the polysialylation of the neural cell adhesion molecule in embryonic stem cells.
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Cites
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Cited by
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins
Varki, A. (2007) · Nature · doi:10.1038/nature05816 · Cited by 853
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A Genetic Approach to Mammalian Glycan Function
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Diversity of Microbial Sialic Acid Metabolism
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Systemic Blockade of Sialylation in Mice with a Global Inhibitor of Sialyltransferases
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Metadata
- Authors
- Schwarzkopf, M., Knobeloch, K.-P., Rohde, E., Hinderlich, S., Wiechens, N., Lucka, L., Horak, I., Reutter, W., & Horstkorte, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-02
- Volume
- 99
- Issue
- 8
- Pages
- 5267-5270
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049633866
- Cited by
- 366
- References
- 25
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Schwarzkopf, M., Knobeloch, K.-P., Rohde, E., Hinderlich, S., Wiechens, N., Lucka, L., Horak, I., Reutter, W., & Horstkorte, R. (2002). Sialylation is essential for early development in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.072066199
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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