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Cited by 340

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation

Open access
Caplice, Noel M., Bunch, T. Jared, Stalboerger, Paul G., Wang, Shaohua, Simper, David, Miller, Dylan V., Russell, Stephen J., Litzow, Mark R., Edwards, William D.·2003·Proceedings of the National Academy of Sciences

Abstract

Atherosclerosis is the major cause of adult mortality in the developed world, and a significant contributor to atherosclerotic plaque progression involves smooth muscle cell recruitment to the intima of the vessel wall. Controversy currently exists on the exact origin of these recruited cells. Here we use sex-mismatched bone marrow transplant subjects to show that smooth muscle cells throughout the atherosclerotic vessel wall can derive from donor bone marrow. We demonstrate extensive recruitment of these cells in diseased compared with undiseased segments and exclude cell–cell fusion events as a cause for this enrichment. These data have broad implications for our understanding of the cellular components of human atherosclerotic plaque and provide a potentially novel target for future diagnostic and therapeutic strategies.

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Crossref · 10.1073/pnas.0730743100

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Citations

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Metadata

Authors
Caplice, N. M., Bunch, T. J., Stalboerger, P. G., Wang, S., Simper, D., Miller, D. V., Russell, S. J., Litzow, M. R., & Edwards, W. D.
Venue
Proceedings of the National Academy of Sciences
Published
2003-03-28
Volume
100
Issue
8
Pages
4754-4759
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2007439146
Cited by
340
References
39
FWCI
10.09
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation. https://app.cochat.ai/papers/10.1073/pnas.0730743100
The paper
Caplice, N. M., Bunch, T. J., Stalboerger, P. G., Wang, S., Simper, D., Miller, D. V., Russell, S. J., Litzow, M. R., & Edwards, W. D. (2003). Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0730743100

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.