The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
NK T cells provide lipid antigen-specific cognate help for B cells
Open accessAbstract
The mechanisms of T cell help for production of antilipid antibodies are largely unknown. This study shows that invariant NK T cells (iNK T cells) and B cells cooperate in a model of antilipid antigen-specific antibody responses. We use a model haptenated lipid molecule, 4-hydroxy-3-nitrophenyl-αGalactosylCeramide (NP-αGalCer), to demonstrate that iNK T cells provide cognate help to lipid-antigen-presenting B cells. B cells proliferate and IgG anti-NP is produced from in vivo -immunized mice and in vitro cocultures of B and NK T cells after exposure to NP-αGalCer, but not closely related control glycolipids. This B cell response is absent in CD1d −/− and Jα18 −/− mice but not CD4 −/− mice. The antibody response to NP-αGalCer is dominated by the IgM, IgG3, and IgG2c isotypes, and marginal zone B cells stimulate better in vitro lipid antigen-driven proliferation than follicular B cells, suggesting an important role for this B cell subset. iNK T cell help for B cells is shown to involve cognate help from CD1d-instructed lipid-specific iNK T cells, with help provided via CD40L, B7–1/B7–2, and IFN-γ, but not IL-4. This model provides evidence of iNK T cell help for antilipid antibody production, an important aspect of infections, autoimmune diseases, and vaccine development. Our findings also now allow prediction of those microbial antigens that would be expected to elicit cognate iNKT cell help for antibody production, namely those that can stimulate iNKT cells and at the same time have a polar moiety that can be recognized by antibodies.
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Cites
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Lymphokine Control of In Vivo Immunoglobulin Isotype Selection
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TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes
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Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
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Murine CD1d-Restricted T Cell Recognition of Cellular Lipids
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Self-citationAutoreactivity by design: innate B and T lymphocytes
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Modulation of CD1d-restricted NKT cell responses by using N- acyl variants of α-galactosylceramides
Yu, K. O. A., Im, J. S., Molano, A., Dutronc, Y., Illarionov, P. A., Forestier, C., Fujiwara, N., Arias, I., Miyake, S., Yamamura, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407488102 · Cited by 337
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Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
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Self-citationAllman, D., & Pillai, S. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.014 · Cited by 536
Self-citationBiology of CD1- and MR1-Restricted T Cells
Salio, M., Silk, J. D., Yvonne Jones, E., & Cerundolo, V. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120243 · Cited by 299
Plasma cell development and survival
Oracki, S. A., Walker, J. A., Hibbs, M. L., Corcoran, L. M., & Tarlinton, D. M. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00940.x · Cited by 268
Pei, B., Vela, J. L., Zajonc, D., & Kronenberg, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06435.x · Cited by 33
Metadata
- Authors
- Leadbetter, E. A., Brigl, M., Illarionov, P., Cohen, N., Luteran, M. C., Pillai, S., Besra, G. S., & Brenner, M. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-06-17
- Volume
- 105
- Issue
- 24
- Pages
- 8339-8344
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017312699
- Cited by
- 254
- References
- 25
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
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