Peripheral B cell subsets
Open accessAbstract
Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.
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“Naive B cells, the largest splenic B cell population, are crucial for T cell-dependent responses [52].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [52]
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- Authors
- Allman, D., & Pillai, S.
- Affiliations
- University of Pennsylvania (US)
- Harvard University (US)
- Corresponding author
- Allman, David
- Pillai, Shiv
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 20
- Issue
- 2
- Pages
- 149-157
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC2532490
- OpenAlex
- W2037250871
- Cited by
- 536
- References
- 0
- Citations by year
- 2026: 14 · 2025: 30 · 2024: 17 · 2023: 21 · 2022: 22 · 2021: 37 · 2020: 34 · 2019: 40 · 2018: 29 · 2017: 28 · 2016: 34 · 2015: 33 · 2014: 29 · 2013: 29 · 2012: 26
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI064930, R21AI057486)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cell development, follicular B cells, marginal zone B cells, B-1 cells, B cell receptor signaling, bone marrow, spleen
- MeSH terms
- Animals, Bone Marrow Cells, Immune Tolerance, Signal Transduction, B-Lymphocyte Subsets, Mice, Receptors, Notch
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