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The H19 locus acts in vivo as a tumor suppressor
Open accessAbstract
The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated in some human tumors, such as Wilms' tumors. In these cases, biallelic IGF2 expression and lack of expression of H19 are associated with hypermethylation of the imprinting center of this locus. These observations and others have suggested a potential tumor suppressor effect of the H19 locus. Some studies have also suggested that H19 is an oncogene, based on tissue culture systems. We show, using in vivo murine models of tumorigenesis, that the H19 locus controls the size of experimental teratocarcinomas, the number of polyps in the Apc murine model of colorectal cancer and the timing of appearance of SV40-induced hepatocarcinomas. The H19 locus thus clearly displays a tumor suppressor effect in mice.
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Cited by
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Anastasiadou, E., Jacob, L. S., & Slack, F. J. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.99 · Cited by 1,884
The functional role of long non-coding RNA in human carcinomas
Gibb, E. A., Brown, C. J., & Lam, W. L. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-38 · Cited by 1,619
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
Kallen, A. N., Zhou, X.-B., Xu, J., Qiao, C., Ma, J., Yan, L., Lu, L., Liu, C., Yi, J.-S., Zhang, H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.027 · Cited by 1,048
lncRNAdb: a reference database for long noncoding RNAs
Amaral, P. P., Clark, M. B., Gascoigne, D. K., Dinger, M. E., & Mattick, J. S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1138 · Cited by 584
The H19 locus: Role of an imprinted non‐coding RNA in growth and development
Gabory, A., Jammes, H., & Dandolo, L. (2010) · BioEssays · doi:10.1002/bies.200900170 · Cited by 568
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Metadata
- Authors
- Yoshimizu, T., Miroglio, A., Ripoche, M.-A., Gabory, A., Vernucci, M., Riccio, A., Colnot, S., Godard, C., Terris, B., Jammes, H., & Dandolo, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-08-26
- Volume
- 105
- Issue
- 34
- Pages
- 12417-12422
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2032555022
- Cited by
- 336
- References
- 0
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Yoshimizu, T., Miroglio, A., Ripoche, M.-A., Gabory, A., Vernucci, M., Riccio, A., Colnot, S., Godard, C., Terris, B., Jammes, H., & Dandolo, L. (2008). The H19 locus acts in vivo as a tumor suppressor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0801540105
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