Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system

Xue, Mingshan, Stradomska, Alicja, Chen, Hongmei, Brose, Nils, Zhang, Weiqi, Rosenmund, Christian, Reim, Kerstin·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0803012105

Cited by (137)

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  4. The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses
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  5. Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction
    Joseph A. Szule · 2022 · Frontiers in Synaptic Neuroscience
  6. Complexins ☆
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  8. Spectroscopic Characterization of Structure–Function Relationships in the Intrinsically Disordered Protein Complexin
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  9. Molecular and Morphological Correlates of Synaptic Vesicle Priming
    Cordelia Imig · 2014
  10. Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology
    Jennifer L. Day, Marilyn Tirard, Nils Brose · 2024 · Frontiers in Molecular Neuroscience
  11. Complexin gains effective access to the assembling SNAREs via its membrane-binding C-terminal domain
    Justine A Lottermoser, Hao-Wen Liu, Jihong Bai, Zhitao Hu, J. Dittman · 2025 · Journal of Physiology
  12. Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion
    Francisco José López-Murcia, Kerstin Reim, Holger Taschenberger · 2023 · Advances in neurobiology
  13. Synergistic SNARE Modulators of Neurotransmission: Complexins and SNAP-29
    Nandhini Sivakumar · 2016
  14. Regulation of Exocytosis by Complexin
    O. Shin · 2015 · Journal of Biochemistry and Molecular Biology Research
  15. Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission
    Nadezhda S. Sabeva, Richard W. Cho, Alexander Vasin, Agustin Gonzalez, J. Troy Littleton, Maria Bykhovskaia · 2017 · Journal of Neuroscience
  16. Proteomic changes induced by harmine in human brain organoids reveal signaling pathways related to neuroprotection
    Karina Karmirian, L. Goto-Silva, J. Nascimento, Marcelo N. Costa, José Alexandre Salerno, I. Ornelas, B. Vanderborght, D. Martins-de-Souza, S. Rehen · 2021 · bioRxiv
  17. Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion
    Estelle Toulmé, Jacqueline Murach, Simon Bärfuss, Jana Kroll, Jörg Malsam, Thorsten Trimbuch, Melissa A. Herman, Thomas H. Söllner, Christian Rosenmund · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Investigation of the molecular mechanism of SNARE-mediated membrane fusion
    Bin Lu · 2010
  19. Presynaptic molecular mechanisms that control quantal neurotransmitter discharge
    Raul Guzman Castro · 2009 · Publications of the UdS (Saarland University)
  20. THE FUNCTIONAL ORGANIZATION OF SYNAPTIC VESICLE POOLS IN A RETINAL BIPOLAR NEURON
    Proleta Datta · 2012 · Digital Commons-TMC (Texas Medical Center)
  21. The potential of exercise to reverse stress induced abnormalities in the rat brain
    Lelanie Marais · 2010 · SUNScholar (Stellenbosch University)
  22. Structural and functional study of SNARE machinery in neurotransmitt er release
    Shuang Song · 2013
  23. Article Complexin Maintains Vesicles in the Primed State in C. elegans
    Robert J. Hobson, Qiang Liu, Shigeki Watanabe, Erik M. Jørgensen · 2011
  24. Phenotype-based genetic association studies in schizophrenia: Proof-of-principle for cognition-relevant genes.
    Sabrina Grube · 2011
  25. Presynaptic Protein Interactions that Regulate Synaptic Strength at Crayfish Neuromuscular Junctions.
    Rene Christopher Prashad · 2012 · TSpace (University of Toronto)
  26. Kinetic structure of recycling vesicle pool at the Calyx of Held synapse under in vivo-like activities
    Zili Liu, Ying Zhu, Yubing Hu, Jianyuan Sun · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Klonieren und Charakterisieren von P/Q-Typ-Calciumkanälen für Mikroskopie an lebenden Zellen
    M Torkko Juha · 2013
  28. Faculty Opinions recommendation of Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
    Michael V. Johnston, Parastoo Jangouk · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  29. Faculty Opinions recommendation of Postsynaptic complexin controls AMPA receptor exocytosis during LTP.
    Josep Rizo · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  30. Faculty Opinions recommendation of Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.
    J. Troy Littleton, Richard Cho · 2014 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  31. Faculty Opinions recommendation of Complexin maintains vesicles in the primed state in C. elegans.
    J. Troy Littleton, Richard Cho · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  32. Differential Regulation of Excitatory vs Inhibitory Synaptic Release by Complexin/CPX-1 and CAPS/UNC-31 at the C. elegans Neuromuscular Junctions
    Ya Wang, Chun Hin Chow, Mengjia Huang, Randa Higazy, Neeraja Ramakrishnan, Cuntai Zhang, Shuzo Sugita, Shangbang Gao · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
    Theocharis Alvanos · 2023
  34. Photogenetics Inhibits the Activity of Glutamate Neurons Projected from the Motor Cortex to the Ventroposterolateral Nucleus of the Thalamus to Alleviates Central Post-Stroke Pain in Rats
    Chao Deng, Yajuan Gu, Tao Xu · 2024 · Research Square
  35. Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion
    Estelle Toulmé, Jacqueline Murach, Simon Bärfuss, Jana Kroll, Jörg Malsam, Thorsten Trimbuch, Melissa A. Herman, Thomas H. Söllner, Christian Rosenmund · 2024 · Journal of Neuroscience
  36. Readily Releasable Pool
    Sina Zobel, Christian Rosenmund · 2024 · Neuromethods
  37. Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
    Ya Wang, Yixiang Deng, N. M. Xia, Shuzo Sugita, Shangbang Gao · 2026 · Advanced Science