Cited by 137Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system

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Xue, Mingshan, Stradomska, Alicja, Chen, Hongmei, Brose, Nils, Zhang, Weiqi, Rosenmund, Christian, Reim, Kerstin·2008·Proceedings of the National Academy of Sciences

Abstract

Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca 2+ -triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery.

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Crossref · 10.1073/pnas.0803012105

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Authors
Xue, M., Stradomska, A., Chen, H., Brose, N., Zhang, W., Rosenmund, C., & Reim, K.
Affiliations
  • Baylor College of Medicine (US)
  • University of Göttingen (DE)
  • Max Planck Institute of Experimental Medicine (DE)
Venue
Proceedings of the National Academy of Sciences
Published
2008-06-03
Volume
105
Issue
22
Pages
7875-7880
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1986777984
Cited by
137
References
33
Citations by year
2026: 1 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 14 · 2015: 7 · 2014: 11 · 2013: 14 · 2012: 10
FWCI
5.54
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion)
  • GRO (submittedVersion, cc-by)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS050655, NS50655)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
complexin, neurotransmitter release, synaptic vesicle exocytosis, excitatory synapses, inhibitory synapses, calcium-triggered release, spontaneous release, synaptic vesicle fusion, central nervous system, mouse brain, gene deletion
MeSH terms
Animals, Brain, Calcium, Evoked Potentials, Exocytosis, Eye Proteins, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Synaptic Vesicles, Mice, Knockout, Neurotransmitter Agents, Adaptor Proteins, Vesicular Transport, Adaptor Proteins, Signal Transducing, Mice

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