Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
Open accessAbstract
Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca 2+ -triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery.
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Cplx3 regulates synaptic neurotransmitter release of both excitatory and inhibitory synapses.
“Cplx3 that was significantly downregulated in the quadruple knockout hippocampus regulates the synaptic neurotransmitter release of both excitatory and inhibitory synapses64.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [64]
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- Authors
- Xue, M., Stradomska, A., Chen, H., Brose, N., Zhang, W., Rosenmund, C., & Reim, K.
- Affiliations
- Baylor College of Medicine (US)
- University of Göttingen (DE)
- Max Planck Institute of Experimental Medicine (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-06-03
- Volume
- 105
- Issue
- 22
- Pages
- 7875-7880
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2409395
- OpenAlex
- W1986777984
- Cited by
- 137
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 14 · 2015: 7 · 2014: 11 · 2013: 14 · 2012: 10
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion)
- GRO (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS050655, NS50655)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- complexin, neurotransmitter release, synaptic vesicle exocytosis, excitatory synapses, inhibitory synapses, calcium-triggered release, spontaneous release, synaptic vesicle fusion, central nervous system, mouse brain, gene deletion
- MeSH terms
- Animals, Brain, Calcium, Evoked Potentials, Exocytosis, Eye Proteins, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Synaptic Vesicles, Mice, Knockout, Neurotransmitter Agents, Adaptor Proteins, Vesicular Transport, Adaptor Proteins, Signal Transducing, Mice
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