The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice
Open accessAbstract
In older adults, mildly elevated plasma total homocysteine (hyperhomocysteinemia) is associated with increased risk of cognitive impairment, cerebrovascular disease, and Alzheimer's disease, but it is uncertain whether this is due to underlying metabolic, neurotoxic, or vascular processes. We report here that feeding male C57BL6/J mice a B-vitamin-deficient diet for 10 weeks induced hyperhomocysteinemia, significantly impaired spatial learning and memory, and caused a significant rarefaction of hippocampal microvasculature without concomitant gliosis and neurodegeneration. Total hippocampal capillary length was inversely correlated with Morris water maze escape latencies ( r = −0.757, P < 0.001), and with plasma total homocysteine ( r = −0.631, P = 0.007). Feeding mice a methionine-rich diet produced similar but less pronounced effects. Our findings suggest that cerebral microvascular rarefaction can cause cognitive dysfunction in the absence of or preceding neurodegeneration. Similar microvascular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive decline.
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Cerebral microvascular pathology in aging and Alzheimer's disease
Farkas, E., & Luiten, P. G. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00068-x · Cited by 1,102
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Age and gender effects on microglia and astrocyte numbers in brains of mice
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Cited by
Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970
Homocysteine, B Vitamins, and Cognitive Impairment
Smith, A. D., & Refsum, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050947 · Cited by 513
Daulatzai, M. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23777 · Cited by 429
Bhattacharyya, S., Saha, S., Giri, K., Lanza, I. R., Nair, K. S., Jennings, N. B., Rodriguez-Aguayo, C., Lopez-Berestein, G., Basal, E., Weaver, A. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079167 · Cited by 254
Tucsek, Z., Toth, P., Tarantini, S., Sosnowska, D., Gautam, T., Warrington, J. P., Giles, C. B., Wren, J. D., Koller, A., Ballabh, P., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu080 · Cited by 191
Metadata
- Authors
- Troen, A. M., Shea-Budgell, M., Shukitt-Hale, B., Smith, D. E., Selhub, J., & Rosenberg, I. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-08-26
- Volume
- 105
- Issue
- 34
- Pages
- 12474-12479
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2122713435
- Cited by
- 183
- References
- 8
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Troen, A. M., Shea-Budgell, M., Shukitt-Hale, B., Smith, D. E., Selhub, J., & Rosenberg, I. H. (2008). B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0805350105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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