The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation
Open accessAbstract
Hydrogen sulfide (H 2 S) is synthesized by 2 enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). l -Cysteine ( l -Cys) acts as a natural substrate for the synthesis of H 2 S. Human penile tissue possesses both CBS and CSE, and tissue homogenates efficiently convert l -Cys to H 2 S. CBS and CSE are localized in the muscular trabeculae and the smooth-muscle component of the penile artery, whereas CSE but not CBS is also expressed in peripheral nerves. Exogenous H 2 S [sodium hydrogen sulfide (NaHS)] or l -Cys causes a concentration-dependent relaxation of strips of human corpus cavernosum. l -Cys relaxation is inhibited by the CBS inhibitor, aminoxyacetic acid (AOAA). Electrical field stimulation of human penile tissue, under resting conditions, causes an increase in tension that is significantly potentiated by either propargylglycine (PAG; CSE inhibitor) or AOAA. In rats, NaHS and l -Cys promote penile erection, and the response to l -Cys is blocked by PAG. Our data demonstrate that the l -Cys/H 2 S pathway mediates human corpus cavernosum smooth-muscle relaxation.
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Cites
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006
Wallace, J. L., Caliendo, G., Santagada, V., Cirino, G., & Fiorucci, S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.042 · Cited by 271
Self-citation
Cited by
Hydrogen Sulfide and Cell Signaling
Li, L., Rose, P., & Moore, P. K. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100505 · Cited by 1,296
Shamloul, R., & Ghanem, H. (2013) · The Lancet · doi:10.1016/s0140-6736(12)60520-0 · Cited by 1,091
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
Self-citationSzabo, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423
Metadata
- Authors
- d'Emmanuele di Villa Bianca, R., Sorrentino, R., Maffia, P., Mirone, V., Imbimbo, C., Fusco, F., De Palma, R., Ignarro, L. J., & Cirino, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-03-17
- Volume
- 106
- Issue
- 11
- Pages
- 4513-4518
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038716568
- Cited by
- 199
- References
- 3
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- green
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- d'Emmanuele di Villa Bianca, R., Sorrentino, R., Maffia, P., Mirone, V., Imbimbo, C., Fusco, F., De Palma, R., Ignarro, L. J., & Cirino, G. (2009). Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0807974105
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