Erectile dysfunction
Abstract
Erectile dysfunction is a common clinical entity that affects mainly men older than 40 years. In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and hypertension, several common lifestyle factors, such as obesity, limited or an absence of physical exercise, and lower urinary tract symptoms, have been linked to the development of erectile dysfunction. Substantial steps have been taken in the study of the association between erectile dysfunction and cardiovascular disease. Erectile dysfunction is a strong predictor for coronary artery disease, and cardiovascular assessment of a non-cardiac patient presenting with erectile dysfunction is now recommended. Substantial advances have occurred in the understanding of the pathophysiology of erectile dysfunction that ultimately led to the development of successful oral therapies, namely the phosphodiesterase type 5 inhibitors. However, oral phosphodiesterase type 5 inhibitors have limitations, and present research is thus investigating cutting-edge therapeutic strategies including gene and cell-based technologies with the aim of discovering a cure for erectile dysfunction.
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The majority of review papers and clinical guidelines on ED approach assessment and treatment from a purely medical perspective and pay little attention to psychosocial aspects.
“By now, there are several review papers and clinical guidelines available on ED,9, 10, 11, 12, 13 but the majority of these papers approach the assessment and treatment of ED from a purely medical perspective and pay only little attention to describing the psychosocial aspects of ED.”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [11]
Medical treatment of ED follows a stepwise program from less invasive to more invasive modalities.
“The medical treatment of ED follows a stepwise program, moving from less invasive treatments such as lifestyle changes, pelvic floor exercises, and medication (changes) to more invasive modalities such as the use of mechanical devices, intracavernous injections, and surgical implantation of a penile prosthesis.9, 10, 11, 12”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [11]
Shared decision-making predicts a better course, adherence, and outcome of therapy because patients have more realistic treatment expectations.
“Not only does shared decision-making increase patient autonomy, it also predicts a better course, adherence, and outcome of therapy because patients have more realistic treatment expectations.10, 11, 12”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [11]
Cites
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271 · see citing works
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849 · see citing works
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074 · see citing works
Rosen, R., Cappelleri, J. C., Smith, M., Lipsky, J., & Peña, B. (1999) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900472 · Cited by 3,069 · see citing works
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597 · see citing works
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120 · see citing works
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Santos, R. A. S., Silva, A. C. S. E., Maric, C., Silva, D. M. R., Machado, R. P., de Buhr, I., Heringer‐Walther, S., Pinheiro, S. V. B., Lopes, M. T., Bäder, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432869100 · Cited by 1,805 · see citing works
Aytaç, Mckinlay, & Krane (1999) · BJU International · doi:10.1046/j.1464-410x.1999.00142.x · Cited by 1,329 · see citing works
Lue, T. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422407 · Cited by 1,261 · see citing works
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
Hatzimouratidis, K., Amar, E., Eardley, I., Giuliano, F., Hatzichristou, D., Montorsi, F., Vardi, Y., & Wespes, E. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.020 · Cited by 1,223 · see citing works
Somlyo, A. P., & Somlyo, A. V. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00177.x · Cited by 1,203 · see citing works
JOHANNES, C. B., ARAUJO, A. B., FELDMAN, H. A., DERBY, C. A., KLEINMAN, K. P., & McKINLAY, J. B. (2000) · Journal of Urology · doi:10.1016/s0022-5347(05)67900-1 · Cited by 1,158 · see citing works
The Arizona Sexual Experience Scale (ASEX): Reliability and Validity
A. McGahuey, A. J. G. (2000) · Journal of Sex & Marital Therapy · doi:10.1080/009262300278623 · Cited by 1,155 · see citing works
Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey’
Braun, M., Wassmer, G., Klotz, T. H., Reifenrath, B., Mathers, M., & Engelmann, U. (2000) · International journal of impotence research · doi:10.1038/sj.ijir.3900622 · Cited by 981 · see citing works
The endoplasmic reticulum: a multifunctional signaling organelle
Berridge, M. J. (2002) · Cell Calcium · doi:10.1016/s0143416002001823 · Cited by 978 · see citing works
Summary of the Recommendations on Sexual Dysfunctions in Men
Montorsi, F., Adaikan, G. P., Becher, E. F., Giuliano, F., Khoury, S., Lue, T. F., Sharlip, I. D., Althof, S. E., Andersson, K., Brock, G. B., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02062.x · Cited by 937 · see citing works
Erectile Dysfunction and Subsequent Cardiovascular Disease
Thompson, I. M. (2005) · JAMA · doi:10.1001/jama.294.23.2996 · Cited by 883 · see citing works
Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: A Randomized Controlled Trial
Esposito, K., Giugliano, F., Di Palo, C., Giugliano, G., Marfella, R., D'Andrea, F., D'Armiento, M., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.291.24.2978 · Cited by 841 · see citing works
Bacon, C. G., Mittleman, M. A., Kawachi, I., Giovannucci, E., Glasser, D. B., & Rimm, E. B. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00005 · Cited by 832 · see citing works
ORIGINAL ARTICLES: Definitions/Epidemiology/Risk Factors for Sexual Dysfunction
Lewis, R. W., Fugl-Meyer, K. S., Corona, G., Hayes, R. D., Laumann, E. O., Moreira, E. D., Rellini, A. H., & Segraves, T. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01778.x · Cited by 823 · see citing works
Fukata, Y., Kaibuchi, K., Amano, M., & Kaibuchi, K. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01596-0 · Cited by 748 · see citing works
Khaw, K.-T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., Welch, A., & Day, N. (2007) · Circulation · doi:10.1161/circulationaha.107.719005 · Cited by 743 · see citing works
Role of TNF-α in vascular dysfunction
Zhang, H., Park, Y., Wu, J., Chen, X. P., Lee, S., Yang, J., Dellsperger, K. C., & Zhang, C. (2009) · Clinical Science · doi:10.1042/cs20080196 · Cited by 683 · see citing works
Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?
Derby, C. A., Mohr, B. A., Goldstein, I., Feldman, H. A., Johannes, C. B., & McKinlay, J. B. (2000) · Urology · doi:10.1016/s0090-4295(00)00614-2 · Cited by 552 · see citing works
Martín‐Morales, A., Sánchez-Cruz, J. J., de Tejada, I. S., Rodriguez-Vela, L., Jiménez-Cruz, J. F., & BURGOS-RODRIGUEZ, R. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65986-1 · Cited by 551 · see citing works
Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα
Surks, H. K., Mochizuki, N., Kasai, Y., Georgescu, S. P., Tang, K. M., Ito, M., Lincoln, T., & Mendelsohn, M. E. (1999) · Science · doi:10.1126/science.286.5444.1583 · Cited by 527 · see citing works
(2005) · doi:10.1016/j.ucl.2005.08.007 · Cited by 517 · see citing works
Nicolosi, A., Moreira, E. D., Shirai, M., Ismail Bin Mohd Tambi, M., & Glasser, D. B. (2003) · Urology · doi:10.1016/s0090-4295(02)02102-7 · Cited by 499 · see citing works
Elevated plasma endothelin in patients with diabetes mellitus
Takahashi, K., Ghatei, M. A., Lam, H. ‐., O’Halloran, D., & Bloom, S. R. (1990) · Diabetologia · doi:10.1007/bf00403325 · Cited by 489 · see citing works
IS IMPOTENCE AN ARTERIAL DISORDER?
Virag, R., Bouilly, P., & Frydman, D. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92023-9 · Cited by 479 · see citing works
Nehra, A. X., Jackson, G., Miner, M. M., Billups, K. L., Burnett, A. L. “., Buvat, J., Carson, C. C., Cunningham, G. R., Ganz, P., Goldstein, I., et al. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.06.015 · Cited by 472 · see citing works
Anatomy, Physiology, and Pathophysiology of Erectile Dysfunction
Gratzke, C., Angulo, J., Chitaley, K., Dai, Y.-T., Kim, N. N., Paick, J.-S., Simonsen, U., Ückert, S., Wespes, E., Andersson, K. E., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01624.x · Cited by 470 · see citing works
Sexual behavior in male rodents
Hull, E. M., & Dominguez, J. M. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.03.030 · Cited by 467 · see citing works
Dopamine and serotonin: influences on male sexual behavior
Hull, E. M., Muschamp, J. W., & Sato, S. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.018 · Cited by 465 · see citing works
Grimm, R. H., Grandits, G. A., Prineas, R. J., McDonald, R. H., Lewis, C. E., Flack, J. M., Yunis, C., Svendsen, K. H., Liebson, P. R., Elmer, P. J., et al. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.8 · Cited by 459 · see citing works
Erectile Dysfunction and Risk of Cardiovascular Disease
Dong, J.-Y., Zhang, Y., & Qin, L.-Q. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.024 · Cited by 450 · see citing works
Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study
Corona, G., Rastrelli, G., Monami, M., Guay, A., Buvat, J., Sforza, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0447 · Cited by 435 · see citing works
A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease
Inman, B. A., Sauver, J. L. S., Jacobson, D. J., McGree, M. E., Nehra, A. X., Lieber, M. M., Roger, V. L., & Jacobsen, S. J. (2009) · Mayo Clinic Proceedings · doi:10.4065/84.2.108 · Cited by 421 · see citing works
Seftel, A. D., SUN, P., & Swindle, R. W. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000125198.32936.38 · Cited by 412 · see citing works
SHABSIGH, R., KAUFMAN, J. M., STEIDLE, C., & PADMA-NATHAN, H. (2004) · Journal of Urology · doi:10.1097/01.ju.0000132389.97804.d7 · Cited by 406 · see citing works
Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction
Andersson, K. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004515 · Cited by 399 · see citing works
Calcium signalling remodelling and disease
Berridge, M. J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110766 · Cited by 391 · see citing works
Prevalence and Risk Factors for Erectile Dysfunction in 2869 Men Using a Validated Questionnaire
PONHOLZER, A., TEMML, C., MOCK, K., MARSZALEK, M., OBERMAYR, R., & MADERSBACHER, S. (2005) · European Urology · doi:10.1016/j.eururo.2004.08.017 · Cited by 361 · see citing works
Is Erectile Dysfunction the “Tip of the Iceberg” of a Systemic Vascular Disorder?
Montorsi, P., Montorsi, F., & Schulman, C. C. (2003) · European Urology · doi:10.1016/s0302-2838(03)00307-5 · Cited by 346 · see citing works
Penile length in the flaccid and erect states: guidelines for penile augmentation.
Wessells, H., Lue, T., & Mcaninch, J. (1996) · Journal of Urology · doi:10.1016/s0022-5347(01)65682-9 · Cited by 345 · see citing works
Rho/Rho-kinase mediated signaling in physiology and pathophysiology
Wettschureck, N., & Offermanns, S. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0370-2 · Cited by 335 · see citing works
Bivalacqua, T. J., Champion, H. C., Usta, M. F., Cellek, S., Chitaley, K., Webb, R. C., Lewis, R. L., MILLS, T. M., Hellstrom, W. J. G., & Kadowitz, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400520101 · Cited by 317 · see citing works
Münzel, T., Feil, R., Mülsch, A., Lohmann, S. M., Hofmann, F., & Walter, U. (2003) · Circulation · doi:10.1161/01.cir.0000094403.78467.c3 · Cited by 316 · see citing works
Heart disease risk factors predict erectile dysfunction 25 years later
Fung, M. M., Bettencourt, R., & Barrett-Connor, E. L. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.041 · Cited by 314 · see citing works
Gupta, B. P. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.440 · Cited by 312 · see citing works
Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
Chitaley, K., Wingard, C. J., Webb, R. C., Branam, H., Stopper, V. S., Lewis, R. W., & MILLS, T. M. (2001) · Nature Medicine · doi:10.1038/83258 · Cited by 309 · see citing works
HYPERTENSION IS ASSOCIATED WITH SEVERE ERECTILE DYSFUNCTION
Burchardt, M., Burchardt, T., Baer, L., Kiss, A., Pawar, R. V., Shabsigh, A., TAILLE, A. D. L., Hayek, O., & Shabsigh, R. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67138-8 · Cited by 299 · see citing works
Nicolosi, A., Glasser, D. B., Kim, S. C., Marumo, K., Laumann, E. O., & GSSAB Investigators’ Group (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05348.x · Cited by 290 · see citing works
Nehra, A. X., Goldstein, I., Pabby, A., Nugent, M. A., Huang, Y.-H., Morenas, A. D. L., Krane, R. J., Udelson, D., de Tejada, I. S., & Moreland, R. B. (1996) · The Journal of Urology · doi:10.1016/s0022-5347(01)65578-2 · Cited by 268 · see citing works
Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management
Thorve, V. S., Kshirsagar, A. D., Vyawahare, N. S., Joshi, V. S., Ingale, K., & Mohite, R. (2010) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2010.03.003 · Cited by 265 · see citing works
Vardi, Y., Appel, B., Kilchevsky, A., & Gruenwald, I. (2012) · The Journal of Urology · doi:10.1016/j.juro.2011.12.117 · Cited by 257 · see citing works
Smooth Muscle Cell Heterogeneity
Shanahan, C. M., & Weissberg, P. L. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.3.333 · Cited by 255 · see citing works
Association of Type and Duration of Diabetes With Erectile Dysfunction in a Large Cohort of Men
Bacon, C. G., Hu, F. B., Giovannucci, E. L., Glasser, D. B., Mittleman, M. A., & Rimm, E. B. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1458 · Cited by 255 · see citing works
Pharmacotherapy for Erectile Dysfunction
Ian Eardley, C., Donatucci, C. F., Corbin, J. D., El-Meliegy, A., Konstantinos Hatzimouratidis, A., McVary, K. T., Munarriz, R. M., & Lee, S. W. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01627.x · Cited by 254 · see citing works
Moreland, R. B., Traish, A. M., McMillin, M. A., Smith, B. D., Goldstein, I., & de Tejada, I. S. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67730-9 · Cited by 246 · see citing works
Montorsi, P., Ravagnani, P. M., Galli, S., Salonia, A., Briganti, A., Werba, J. P., & Montorsi, F. (2006) · European Urology · doi:10.1016/j.eururo.2006.07.015 · Cited by 239 · see citing works
Sexual activity in hypertensive men treated with valsartan or carvedilol: a crossover study
Fogari, R. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01214-0 · Cited by 238 · see citing works
Raeymaekers, L., Hofmann, F. B., & Casteels, R. (1988) · Biochemical Journal · doi:10.1042/bj2520269 · Cited by 226 · see citing works
Subclinical Coronary Artery Atherosclerosis in Patients With Erectile Dysfunction
Chiurlia, E., D’Amico, R., Ratti, C., Granata, A. R. M., Romagnoli, R., & Modena, M. G. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.068 · Cited by 226 · see citing works
Giuliano, F., & Rampin, O. (2004) · Physiology and Behavior · doi:10.1016/j.physbeh.2004.08.014 · Cited by 226 · see citing works
The Anatomy of the Tunica Albuginea in the Normal Penis and Peyronie's Disease
Brock, G. B., Hsu, G., Nunes, L., von Heyden, B., & Lue, T. F. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)65359-x · Cited by 225 · see citing works
Kennedy, S. H., Eisfeld, B. S., Dickens, S. E., Bacchiochi, J. R., & Bagby, R. M. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0406 · Cited by 223 · see citing works
Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action
Lee, M. W., & Severson, D. L. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.3.c659 · Cited by 212 · see citing works
A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics
Serretti, A., & Chiesa, A. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328341e434 · Cited by 208 · see citing works
Phosphodiesterase type 5 inhibitors for erectile dysfunction
Carson, C. C., & Lue, T. F. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05614.x · Cited by 203 · see citing works
TESTOSTERONE SUPPLEMENTATION FOR ERECTILE DYSFUNCTION: RESULTS OF A META-ANALYSIS
Jain, P., RADEMAKER, A. W., & McVary, K. T. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67363-6 · Cited by 200 · see citing works
Porst, H., Giuliano, F., Glina, S., Ralph, D. J., Casabé, A. R., Elion‐Mboussa, A., Shen, W., & Whitaker, J. S. (2006) · European Urology · doi:10.1016/j.eururo.2006.02.052 · Cited by 199 · see citing works
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation
Bianca, R. D. D. V., Sorrentino, R., Maffia, P., Mirone, V. G., Imbimbo, C., Fusco, F., Palma, R. D., Ignarro, L. J., & Cirino, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807974105 · Cited by 199 · see citing works
Azadzoi, K. M., & de Tejada, I. S. (1991) · The Journal of Urology · doi:10.1016/s0022-5347(17)37759-5 · Cited by 196 · see citing works
Sexual dysfunctions in depression
Mathew, R. J., & Weinman, M. L. (1982) · Archives of Sexual Behavior · doi:10.1007/bf01541593 · Cited by 196 · see citing works
Recommendations for the Clinical Evaluation of Men and Women with Sexual Dysfunction
Hatzichristou, D., Rosen, R. C., Derogatis, L. R., Low, W. Y., Meuleman, E. J. H., Sadovsky, R., & Symonds, T. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01619.x · Cited by 191 · see citing works
Böhm, M., Baumhäkel, M., Teo, K. K., Sleight, P., Probstfield, J. L., Gao, P., Mann, J. F. E., Díaz, R., Dagenais, G. R., Jennings, G., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.864199 · Cited by 190 · see citing works
Physiological regulation of penile arteries and veins
Prieto, D. (2007) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901581 · Cited by 185 · see citing works
Selective nitrergic neurodegeneration in diabetes mellitus–a nitric oxide‐dependent phenomenon
Cellek, S., Rodrigo, J., Lobos, E., Fernández, A. P., Serrano, J., & Moncada, S. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702981 · Cited by 183 · see citing works
SALTZMAN, E. A., Guay, A. T., & Jacobson, J. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000132368.10458.66 · Cited by 179 · see citing works
The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals
Argiolas, A., & Melis, M. R. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.019 · Cited by 177 · see citing works
Kifor, I., Williams, G. H., Vickers, M. A., et al. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64901-2 · Cited by 177 · see citing works
The efficacy of sildenafil citrate (Viagra®) in clinical populations: an update
Carson, C. C., Burnett, A. L. “., Levine, L. A., & Nehra, A. X. (2002) · Urology · doi:10.1016/s0090-4295(02)01687-4 · Cited by 174 · see citing works
A Comparative Review of the Options for Treatment of Erectile Dysfunction
Konstantinos Hatzimouratidis, A., & Hatzichristou, D. G. (2005) · Drugs · doi:10.2165/00003495-200565120-00003 · Cited by 172 · see citing works
Traish, A. M., & Kim, N. N. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00094.x · Cited by 170 · see citing works
Effects of Medical or Surgical Castration on Erectile Function in an Animal Model
Traish, A. M., Munarriz, R. M., O'Connell, L., Choi, S., Kim, S. W., Kim, N. N., Huang, Y.-H., & Goldstein, I. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02686.x · Cited by 168 · see citing works
The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy
Mehrotra, N., Gupta, M., Kovar, A., & Meibohm, B. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901522 · Cited by 161 · see citing works
Erectile dysfunction in the community: a prevalence study
Pinnock, C. B., Stapleton, A. M. F., & Marshall, V. R. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb123691.x · Cited by 160 · see citing works
Mediterranean diet improves erectile function in subjects with the metabolic syndrome
Esposito, K., Ciotola, M., Giugliano, F. M., SIO, M. D., Giugliano, G., D’Armiento, M., & Giugliano, D. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901447 · Cited by 160 · see citing works
Lifetime Depression History and Sexual Function in Women at Midlife
Cyranowski, J. M., Bromberger, J. T., Youk, A. O., Matthews, K. A., Kravitz, H. M., & Powell, L. H. (2004) · Archives of Sexual Behavior · doi:10.1023/b:aseb.0000044738.84813.3b · Cited by 157 · see citing works
(1994) · doi:10.1093/oxfordjournals.aje.a117189 · Cited by 154 · see citing works
Ultrastructural Changes in Impotent Penile Tissue: A Comparison of 65 Patients
Mersdorf, A., Goldsmith, P. C., Diederichs, W., et al. (1991) · The Journal of Urology · doi:10.1016/s0022-5347(17)38443-4 · Cited by 153 · see citing works
The Structure and Innervation of Smooth Muscle in the Wall of the Bladder Neck and Proximal Urethra
GOSLING, J. A., & Dixon, J. S. (1975) · British Journal of Urology · doi:10.1111/j.1464-410x.1975.tb06260.x · Cited by 152 · see citing works
Computerized Analysis of Smooth Muscle Fibers in Potent and Impotent Patients
Wespes, E., de Góes, P. M., Schiffmann, S. N., Depierreux, M., Vanderhaeghen, J., & Schulman, C. C. (1991) · The Journal of Urology · doi:10.1016/s0022-5347(17)37990-9 · Cited by 151 · see citing works
Bivalacqua, T. J., Deng, W., Kendirci, M., Usta, M. F., Robinson, C., Taylor, B. K., Murthy, S. N., Champion, H. C., Hellstrom, W. J. G., & Kadowitz, P. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00685.2006 · Cited by 149 · see citing works
Impact of erectile dysfunction and its subsequent treatment with sildenafil: qualitative study
Tomlinson, J., & Wright, D. (2004) · BMJ · doi:10.1136/bmj.38044.662176.ee · Cited by 147 · see citing works
Guay, A. T., Perez, J. B., Jacobson, J., & Newton, R. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02582.x · Cited by 143 · see citing works
The process of care model for evaluation and treatment of erectile dysfunction
Rosen, R. (1999) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900411 · Cited by 143 · see citing works
Bocchio, M., Desideri, G., Scarpelli, P., Necozione, S., Properzi, G., Spartera, C., Francavilla, F., Ferri, C., & Francavilla, S. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000116325.06572.85 · Cited by 139 · see citing works
Cardiovascular risk, drugs and erectile function - a systematic analysis
Baumhäkel, M., Schlimmer, N., Kratz, M., et al. (2011) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02563.x · Cited by 138 · see citing works
Behr‐Roussel, D., Gorny, D., Mevel, K., Caisey, S., Bernabé, J., Burgess, G. M., Wayman, C., Alexandre, L., & Giuliano, F. (2004) · European Urology · doi:10.1016/j.eururo.2004.09.005 · Cited by 132 · see citing works
Effects of Intensive Lifestyle Changes on Erectile Dysfunction in Men
Esposito, K., Ciotola, M., Giugliano, F., Maiorino, M. I., Autorino, R., De Sio, M., Giugliano, G., Nicoletti, G., D’Andrea, F., & Giugliano, D. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01030.x · Cited by 132 · see citing works
Androgens and Penile Erection: A Review
MILLS, T. M., Reilly, C. M., & Lewis, R. W. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01847.x · Cited by 126 · see citing works
Doumas, M. N., Tsakiris, A. K., Δούμα, Σ., Grigorakis, A., Papadopoulos, A., Hounta, A., Tsiodras, S., Dimitriou, D., & Giamarellou, H. (2006) · Journal of Andrology · doi:10.2164/jandrol.04191 · Cited by 124 · see citing works
Ferrini, M. G., Kovanecz, I., Sanchez, S. P., Vernet, D. A., Davila, H. H., Rajfer, J., & González-Cadavid, N. F. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.106.059642 · Cited by 123 · see citing works
Epidemiology of Erectile Dysfunction: the Role of Medical Comorbidities and Lifestyle Factors
Rosen, R. C., Wing, R. R., Schneider, S., & Gendrano, N. (2005) · Urologic Clinics of North America · doi:10.1016/j.ucl.2005.08.004 · Cited by 121 · see citing works
Nehra, A. X., Azadzoi, K. M., Moreland, R. B., Pabby, A., Siroky, M. B., Krane, R. J., Goldstein, I., & Udelson, D. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63311-1 · Cited by 119 · see citing works
Patient and Partner Satisfaction after AMS Inflatable Penile Prosthesis Implant
Bettocchi, C., Palumbo, F., Spilotros, M., Lucarelli, G. T., Palazzo, S., Battaglia, M., Selvaggi, F. P., & Ditonno, P. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01499.x · Cited by 119 · see citing works
Penile rehabilitation following radical prostatectomy
Mulhall, J. P. (2008) · Current Opinion in Urology · doi:10.1097/mou.0b013e3283136462 · Cited by 117 · see citing works
h Maxi-K Gene Transfer in Males with Erectile Dysfunction: Results of the First Human Trial
Melman, A., Bar-Chama, N. C., McCullough, A., Davies, K. P., & Christ, G. J. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.1165 · Cited by 116 · see citing works
Effects of first-line antihypertensive agents on sexual function and sex hormones
Suzuki, H., Tominaga, T., Kumagai, H., et al. (1988) · Journal of Hypertension · doi:10.1097/00004872-198812040-00204 · Cited by 115 · see citing works
The Microarchitecture of the Intracavernosal Smooth Muscle and the Cavernosal Fibrous Skeleton
Goldstein, A. M. B., & Padma-Nathan, H. (1990) · The Journal of Urology · doi:10.1016/s0022-5347(17)39677-5 · Cited by 115 · see citing works
Fisher, W. A., Rosen, R. C., Ian Eardley, C., Niederberger, C., Nadel, A., Kaufman, J. M., & Sand, M. S. (2004) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2004.04023.x · Cited by 114 · see citing works
Anatomy and Strength of the Tunica Albuginea: Its Relevance to Penile Prosthesis Extrusion
Hsu, G., Brock, G. B., Martínez‐Piñeiro, L., von Heyden, B., Lue, T. F., & Tanagho, E. A. (1994) · The Journal of Urology · doi:10.1016/s0022-5347(17)35214-x · Cited by 113 · see citing works
Pathophysiology and treatment of diabetic erectile dysfunction
Moore, C. R., & Wang, R. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00223.x · Cited by 113 · see citing works
Beneficial Impact of Exercise and Obesity Interventions on Erectile Function and its Risk Factors
Hannan, J. L., Maio, M. T., Komolova, M., & Adams, M. A. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01143.x · Cited by 110 · see citing works
Symptoms of Diabetes and Their Association With the Risk and Presence of Diabetes
Clark, N., Fox, K., & Grandy, S. (2007) · Diabetes Care · doi:10.2337/dc07-0816 · Cited by 110 · see citing works
Etiology of Diabetic Impotence
Lehman, T. P., & Jacobs, J. (1983) · The Journal of Urology · doi:10.1016/s0022-5347(17)52057-1 · Cited by 107 · see citing works
Quek, K. F., Sallam, A. A., Ng, C. H., et al. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00423.x · Cited by 103 · see citing works
Circulating endothelial progenitor cells in subjects with erectile dysfunction
Foresta, C., Caretta, N., Lana, A., et al. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901311 · Cited by 102 · see citing works
Maio, G. D., Saraeb, S., & Marchiori, A. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01783.x · Cited by 101 · see citing works
Collagen Alterations in the Corpus Cavernosum of Men With Sexual Dysfunction
Luangkhot, R., Rutchik, S. D., Agarwal, V., et al. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)36630-2 · Cited by 100 · see citing works
Regulation of vascular smooth muscle tone
Walsh, M. P. (1994) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y94-130 · Cited by 100 · see citing works
Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence
Becker, A. J., Ückert, S., Stief, C. G., et al. (2001) · Urology · doi:10.1016/s0090-4295(00)00881-5 · Cited by 99 · see citing works
NADPH Oxidase Activation: A Mechanism of Hypertension-Associated Erectile Dysfunction
Jin, L., Lagoda, G. A., Leite, R., Webb, R. C., & Burnett, A. L. “. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00733.x · Cited by 98 · see citing works
Cheng, J. Y. W., & Ng, E. M. L. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803639 · Cited by 95 · see citing works
Prevalence of sleep apnea in men with erectile dysfunction
Hirshkowitz, M., Karacan, I., Arcasoy, M. O., et al. (1990) · Urology · doi:10.1016/0090-4295(90)80262-l · Cited by 95 · see citing works
Efficacy and safety of transurethral alprostadil therapy in men with erectile dysfunction
Williams, Abbou, Amar, A., Desvaux, Flam, Nijeholt, L. À., Lynch, Morgan, MÜller, Porst, et al. (1998) · British Journal of Urology · doi:10.1046/j.1464-410x.1998.00703.x · Cited by 93 · see citing works
Long-Term Safety and Efficacy of Tadalafil 5 mg Dosed Once Daily in Men with Erectile Dysfunction
Porst, H., Rajfer, J., Casabé, A. R., et al. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00935.x · Cited by 92 · see citing works
Altered Penile Vascular Reactivity and Erection in the Zucker Obese-Diabetic Rat
Wingard, C. J., Fulton, D. J., & Husain, S. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00439.x · Cited by 92 · see citing works
Morelli, A., Chavalmane, A. K., Filippi, S., et al. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01057.x · Cited by 92 · see citing works
Demir, Ö., Akgül, K. T., Akar, Z., Çakmak, Ö., Ozdemir, I., Bölükbaşı, A., Can, E., & Gumus, B. H. (2009) · The Aging Male · doi:10.1080/13685530902777425 · Cited by 92 · see citing works
Keltner, N. L., McAfee, K. M., & Taylor, C. L. (2009) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2002.tb00665.x · Cited by 89 · see citing works
NO synthase in cholinergic nerves and NO‐induced relaxation in the rat isolated corpus cavernosum
Hedlund, P., Alm, P., & Andersson, K. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702556 · Cited by 88 · see citing works
Emerging Role for TNF-α in Erectile Dysfunction
Carneiro, F. S., Webb, R. C., & Tostes, R. C. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01762.x · Cited by 88 · see citing works
Shamloul, R. M., Ghanem, H. M., Fahmy, I., El-Meleigy, A., Ashoor, S., El-Nashaar, A., & Kamel, I. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00071.x · Cited by 86 · see citing works
Self-citationAssociation of Risk Factors and Medical Comorbidities with Male Sexual Dysfunctions
El‐Sakka, A. I. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00342.x · Cited by 85 · see citing works
Lincoln, T., Thompson, M. E., & Cornwell, T. L. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77883-1 · Cited by 85 · see citing works
Aversa, A., Rossi, F., Francomano, D., Bruzziches, R., Bertone, C., Santiemma, V., & Spera, G. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.43 · Cited by 85 · see citing works
The distribution of elastic fibrous elements within the human penis
Hsu, G., Brock, G. B., von Heyden, B., Nunes, L., Lue, T. F., & Tanagho, E. A. (1994) · British Journal of Urology · doi:10.1111/j.1464-410x.1994.tb07645.x · Cited by 84 · see citing works
Sullivan, M. E., Dashwood, M. R., Thompson, C. S., et al. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64195-8 · Cited by 83 · see citing works
Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula
Martin, W. J., McGowan, E., Cashen, D. E., Gantert, L. T., Drisko, J. E., Hom, G. J., Nargund, R. P., Sebhat, I. K., Howard, A. D., der Ploeg, L. H. T. V., et al. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02479-2 · Cited by 83 · see citing works
Recovery of Erectile Function after Brief Aggressive Antihypertensive Therapy
Hale, T. M., Okabe, H., Bushfield, T. L., et al. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64919-1 · Cited by 83 · see citing works
Guay, A. T., & Jacobson, J. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00530.x · Cited by 82 · see citing works
Cavernous Oxygen Tension and Smooth Muscle Fibers: Relation and Function
Sattar, A. A., Salpigides, G., Vanderhaeghen, J., et al. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)66772-7 · Cited by 82 · see citing works
Cyclic Nucleotide Signaling in Cavernous Smooth Muscle
Lin, C., Lin, G., & Lue, T. F. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00080.x · Cited by 80 · see citing works
Rosaínz, M. D. J. A., Ojeda, M. O., Acosta, J. R., Elías-Calles, L. C., González, N. O., Herrera, O. T., Álvarez, C. T. G., Rodríguez, E. M., Estévez‐Báez, M., Seijas, E. Á., et al. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02277.x · Cited by 79 · see citing works
The human sexual response and alcohol and drugs
Miller, N. S., & Gold, M. S. (1988) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(88)90006-2 · Cited by 78 · see citing works
Phosphodiesterase 5 Inhibitors for Erectile Dysfunction
Setter, S. M., Iltz, J. L., Fincham, J. E., et al. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e487 · Cited by 78 · see citing works
Role of penile vascular injury in erectile dysfunction after radical prostatectomy
Aboseif, S. R., Shinohara, K., Breza, J., Jr., BENARD, F., & Narayan, P. A. (1994) · British Journal of Urology · doi:10.1111/j.1464-410x.1994.tb07460.x · Cited by 77 · see citing works
EXPRESSION OF DIFFERENT PHOSPHODIESTERASE GENES IN HUMAN CAVERNOUS SMOOTH MUSCLE
Küthe, A., WIEDENROTH, A., Mägert, H., et al. (2001) · The Journal of Urology · doi:10.1097/00005392-200101000-00079 · Cited by 77 · see citing works
Venous Impotence: Pathophysiology, Diagnosis and Treatment
Wespes, E., & Schulman, C. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)36358-9 · Cited by 77 · see citing works
Azadzoi, K. M., Goldstein, I., Siroky, M. B., et al. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62299-7 · Cited by 77 · see citing works
Köseoğlu, N., Köseoğlu, H., Ceylan, E., et al. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000163259.33846.74 · Cited by 74 · see citing works
Cessation of Smoking Rapidly Decreases erectile Dysfunction
Guay, A. T., Perez, J. B., & Heatley, G. J. (1998) · Endocrine Practice · doi:10.4158/ep.4.1.23 · Cited by 72 · see citing works
Peled, N., Shitrit, D., Fox, B. D., SHLOMI, D., Amital, A., Bendayan, D., & Kramer, M. R. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081088 · Cited by 72 · see citing works
Esposito, K., Ciotola, M., Maiorino, M. I., Giugliano, F., Riccardo Autorino, B., SIO, M. D., Jannini, E. A., Lenzi, A., & Giugliano, D. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01042.x · Cited by 71 · see citing works
Evaluation of vardenafil and sildenafil on cardiac repolarization
Morganroth, J., Ilson, B. E., Shaddinger, B. C., Dabiri, G. A., Patel, B. R., Boyle, D. A., Sethuraman, V. S., & Montague, T. H. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.02.034 · Cited by 70 · see citing works
PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile
Kouvelas, D., Goulas, A., Papazisis, G., et al. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789206971 · Cited by 69 · see citing works
Drug Therapy and Prevalence of Erectile Dysfunction in the Massachusetts Male Aging Study Cohort
Derby, C. A., Barbour, M. M., Hume, A. L., et al. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.7.676.34571 · Cited by 66 · see citing works
Optimizing Treatment for Diabetes Mellitus Induced Erectile Dysfunction
Costabile, R. A. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000077448.31995.99 · Cited by 65 · see citing works
Gonçalves, A. C. D. C., Leite, R., Fraga-Silva, R. A., Pinheiro, S. V. B., Reis, A. B., dos Reis, F. M., Touyz, R. M., Webb, R. C., Alenina, N. V., Bäder, M., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00173.2007 · Cited by 64 · see citing works
Baumhäkel, M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl202 · Cited by 64 · see citing works
Increased Risk of Stroke Among Men with Erectile Dysfunction: A Nationwide Population-Based Study
Chung, S., Chen, Y., Lin, H., & Lin, H.-C. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01973.x · Cited by 63 · see citing works
Safety, Efficacy, and Pharmacokinetic Overview of Low-Dose Daily Administration of Tadalafil
Wrishko, R. E., Sorsaburu, S., Wong, D., Strawbridge, A. B., & McGill, J. M. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01301.x · Cited by 63 · see citing works
Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction
Brioni, J. D., Nakane, M., Hsieh, G. C., Moreland, R. B., Kolasa, T., & Sullivan, J. P. (2002) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900801 · Cited by 63 · see citing works
Pharmacology of erectile dysfunction in man
Cirino, G., Fusco, F., Imbimbo, C., & Mirone, V. G. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.011 · Cited by 63 · see citing works
Erectile dysfunction through the ages
Shah, J. (2002) · British Journal of Urology · doi:10.1046/j.1464-410x.2002.02911.x · Cited by 62 · see citing works
�ckert, S., Hedlund, P., Waldkirch, E. S., et al. (2004) · World Journal of Urology · doi:10.1007/s00345-003-0394-4 · Cited by 62 · see citing works
ANTIHYPERTENSIVE DRUGS INDUCE STRUCTURAL REMODELING OF THE PENILE VASCULATURE
Hale, T. M., OKABE, H., Heaton, J., et al. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)66053-3 · Cited by 62 · see citing works
Dietary factors in erectile dysfunction
Esposito, K., Giugliano, F. M., SIO, M. D., Carleo, D., Palo, C. D., D’Armiento, M., & Giugliano, D. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901438 · Cited by 62 · see citing works
Gooren, L. J., & Saad, F. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00105.x · Cited by 62 · see citing works
Penile Prosthesis Infection: Approaches to Prevention and Treatment
Selph, J. P., & Carson, C. C. (2011) · Urologic Clinics of North America · doi:10.1016/j.ucl.2011.02.007 · Cited by 61 · see citing works
Mittawae, B., El-Nashaar, A., Fouda, A., et al. (2006) · Urology · doi:10.1016/j.urology.2005.09.040 · Cited by 61 · see citing works
Role of Adenosine Signaling in Penile Erection and Erectile Disorders
Phatarpekar, P. V., Wen, J., & Xia, Y. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01555.x · Cited by 60 · see citing works
Rosen, R. C., Link, C. L., O’Leary, M. P., Giuliano, F., Aiyer, L. P., & Mollon, P. (2009) · British Journal of Urology · doi:10.1111/j.1464-410x.2009.08370.x · Cited by 60 · see citing works
Penile and Systemic Endothelial Function in Men with and without Erectile Dysfunction
Vardi, Y., Dayan, L., Apple, B., Gruenwald, I., Ofer, Y., & Jacob, G. (2008) · European Urology · doi:10.1016/j.eururo.2008.07.041 · Cited by 59 · see citing works
Ponholzer, A., Gutjahr, G., Temml, C., et al. (2009) · International Journal of Impotence Research · doi:10.1038/ijir.2009.40 · Cited by 58 · see citing works
Rogers, J. H., Karimi, H., Kao, J. A., et al. (2010) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.22646 · Cited by 58 · see citing works
Supuran, C. T., Mastrolorenzo, A., Bárbaro, G., & Scozzafava, A. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778343118 · Cited by 58 · see citing works
Bank, A. J., Kelly, A. S., Kaiser, D. R., Crawford, W. W., Waxman, B., Schow, D. A., & Billups, K. L. (2006) · Vascular Medicine · doi:10.1177/1358863x06072221 · Cited by 58 · see citing works
Karicheti, V., Giraldi, A. G. E., Zhao, W., et al. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64920-8 · Cited by 57 · see citing works
Luttrell, I. P., Swee, M., STARCHER, B. C., Parks, W. C., & Chitaley, K. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00027.2008 · Cited by 56 · see citing works
Alcohol Consumption and Male Erectile Dysfunction: An Unfounded Reputation for Risk?
Chew, K.-K., Bremner, A., Stuckey, B. G. A., Earle, C. M., & Jamrozik, K. D. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01115.x · Cited by 55 · see citing works
Melanocortin Receptors as Targets in the Treatment of Obesity
Heisler, L. K., Farooqi, I. S., & Lam, D. D. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607780906564 · Cited by 55 · see citing works
Expression of myosin isoforms in smooth muscle cells in the corpus cavernosum penis
DiSanto, M. E., Wang, Z., Menon, C., et al. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.4.c976 · Cited by 55 · see citing works
El-Melegy, N. T., Ali, M. M., & Awad, E. M. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05780.x · Cited by 54 · see citing works
Diagnosis and Treatment of Erectile Dysfunction for Reduction of Cardiovascular Risk
Nehra, A. X., Jackson, G., Miner, M. M., Billups, K. L., Burnett, A. L. “., Buvat, J., Carson, C. C., Cunningham, G. R., Goldstein, I., Guay, A. T., et al. (2013) · The Journal of Urology · doi:10.1016/j.juro.2012.12.107 · Cited by 54 · see citing works
Sato, Y., Christ, G. J., Horita, H., et al. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)68156-6 · Cited by 54 · see citing works
Adenosine Actions are Preserved in Corpus Cavernosum from Obese and Type II Diabetic db/db Mouse
Carneiro, F. S., Giachini, F. R. C., Lima, V. V., Carneiro, Z. N., Leite, R., Inscho, E. W., Tostes, R. C., & Webb, R. C. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00752.x · Cited by 53 · see citing works
Bella, A. J., DeYoung, L., Al-Numi, M., & Brock, G. B. (2007) · European Urology · doi:10.1016/j.eururo.2007.06.048 · Cited by 53 · see citing works
Chen, J. S., Doncel, G. F., Álvarez, C., et al. (1995) · Journal of Andrology · doi:10.1002/j.1939-4640.1995.tb01732.x · Cited by 51 · see citing works
Statins and Erectile Dysfunction
Do, C., Huyghe, É., Lapeyre‐Mestre, M., et al. (2009) · Drug Safety · doi:10.2165/00002018-200932070-00005 · Cited by 51 · see citing works
Treatment Options for Erectile Dysfunction
Brant, W. O., Bella, A. J., & Lue, T. F. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.02.001 · Cited by 51 · see citing works
The importance of risk factor reduction in erectile dysfunction
Jackson, G. (2007) · Current Urology Reports · doi:10.1007/s11934-007-0049-x · Cited by 49 · see citing works
Ryu, J., Shin, H., Song, S. U., Oh, S.-M., Piao, S., Han, J., Park, K.-W., & Suh, J. (2006) · Urology · doi:10.1016/j.urology.2005.12.027 · Cited by 49 · see citing works
Phosphodiesterase-5 Inhibitors: Future Perspectives
Giannitsas, K., & Petros, P. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789206953 · Cited by 48 · see citing works
Erectile Dysfunction in End-Stage Liver Disease Men
Huyghe, É., Kamar, N., Wagner, F., Capietto, A.-H., El-Kahwaji, L., Muscari, F., Plante, P., & Rostaing, L. P. E. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01169.x · Cited by 48 · see citing works
Management of sildenafil treatment failures
Kendirci, M., Tanrıverdi, O., Trost, L. W., & Hellstrom, W. J. G. (2006) · Current Opinion in Urology · doi:10.1097/01.mou.0000250286.60237.a6 · Cited by 47 · see citing works
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2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286 · see citing works
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885 · see citing works
Hippisley-Cox, J., Coupland, C., & Brindle, P. (2017) · BMJ · doi:10.1136/bmj.j2099 · Cited by 1,703 · see citing works
Kinlen, D., Cody, D., & O’Shea, D. (2018) · QJM: An International Journal of Medicine · doi:10.1093/qjmed/hcx152 · Cited by 308 · see citing works
Gerdts (2022) · doi:10.1093/eurheartj/ehac470 · Cited by 241 · see citing works
Linking big five personality traits to sexuality and sexual health: A meta-analytic review
Allen, M. S., & Walter, E. E. (2018) · Psychological Bulletin · doi:10.1037/bul0000157 · Cited by 142 · see citing works
Allen, M. S., & Walter, E. E. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.02.008 · Cited by 137 · see citing works
Allen, M. S., & Walter, E. E. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.01.314 · Cited by 116 · see citing works
Dewitte, M., Bettocchi, C., Carvalho, J., Corona, G., Flink, I., Limoncin, E., Pascoal, P., Reisman, Y., & Van Lankveld, J. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100434 · Cited by 97 · see citing works
Male sexual dysfunction and HIV – A clinical perspective
Santi, D., Brigante, G., Zona, S., Guaraldi, G., & Rochira, V. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2013.314 · Cited by 56 · see citing works
Wassersug, R., & Wibowo, E. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2017.04.09 · Cited by 45 · see citing works
The 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction
Mulhall, J. P., Giraldi, A., Hackett, G., Hellstrom, W. J. G., Jannini, E. A., Rubio-Aurioles, E., Trost, L., & Hassan, T. A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.06.005 · Cited by 40 · see citing works
Sexual dysfunction in young adult survivors of childhood cancer - a population-based study
Hovén, E., Fagerkvist, K., Jahnukainen, K., Ljungman, L., Lähteenmäki, P. M., Axelsson, O., Lampic, C., & Wettergren, L. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.06.014 · Cited by 37 · see citing works
El Taieb, M., Hegazy, E., & Ibrahim, A. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.06.009 · Cited by 22 · see citing works
Menafra, D., de Angelis, C., Garifalos, F., Mazzella, M., Galdiero, G., Piscopo, M., Castoro, M., Verde, N., Pivonello, C., Simeoli, C., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01704-3 · Cited by 15 · see citing works
Xiang, N., Hu, Y., Peng, W., Luo, M., Chen, H., & Zhang, Q. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1400491 · Cited by 1 · see citing works
- Authors
- Shamloul, R., & Ghanem, H.
- Affiliations
- University of Ottawa (CA)
- Cairo University (EG)
- Corresponding author
- Shamloul, Rany
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 381
- Issue
- 9861
- Pages
- 153-165
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W3108094084
- Cited by
- 1,091
- References
- 257
- Citations by year
- 2026: 69 · 2025: 104 · 2024: 125 · 2023: 117 · 2022: 95 · 2021: 105 · 2020: 94 · 2019: 78 · 2018: 71 · 2017: 56 · 2016: 58 · 2015: 42 · 2014: 53 · 2013: 22 · 2012: 1
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Lancet (publishedVersion)
- Colloquium Series on Integrated Systems Physiology From Molecule to Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Association of Urology
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- erectile dysfunction, cardiovascular disease, coronary artery disease, phosphodiesterase-5 inhibitors, pathophysiology, lifestyle factors, obesity, diabetes mellitus, hypertension, lower urinary tract symptoms, physical activity, gene therapy, cell therapy
- MeSH terms
- Humans, Erectile Dysfunction, Male, Penis, Penile Prosthesis, Impotence, Vasculogenic, Phosphodiesterase 5 Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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