CTCF-dependent enhancer-blocking by alternative chromatin loop formation

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845

Capturing Chromosome Conformation

Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344

Cohesin mediates transcriptional insulation by CCCTC-binding factor

Wendt, K. S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., et al. (2008) · Nature · doi:10.1038/nature06634 · Cited by 1,193

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101

Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome

Kim, T. H., Abdullaev, Z., Smith, A. D., Ching, K. A., Loukinov, D. I., Green, R. D., Zhang, M. Q., Lobanenkov, V. V., & Ren, B. (2007) · Cell · doi:10.1016/j.cell.2006.12.048 · Cited by 1,022

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., Jarmuz, A., Canzonetta, C., Webster, Z., Nesterova, T., et al. (2008) · Cell · doi:10.1016/j.cell.2008.01.011 · Cited by 900

CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus

Splinter, E., Heath, H., Kooren, J., Palstra, R.-J., Klous, P., Grosveld, F., Galjart, N., & de Laat, W. (2006) · Genes & Development · doi:10.1101/gad.399506 · Cited by 677

Long-range chromatin regulatory interactions in vivo

Carter, D., Chakalova, L., Osborne, C. S., Dai, Y.-F., & Fraser, P. (2002) · Nature Genetics · doi:10.1038/ng1051 · Cited by 663

The β-globin nuclear compartment in development and erythroid differentiation

Palstra, R.-J., Tolhuis, B., Splinter, E., Nijmeijer, R., Grosveld, F., & de Laat, W. (2003) · Nature Genetics · doi:10.1038/ng1244 · Cited by 559

Boundaries in vertebrate genomes: different solutions to adequately insulate gene expression domains

Moltó, E., Fernandez, A., & Montoliu, L. (2009) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/elp031 · Cited by 23

Kaposi’s Sarcoma-Associated Herpesvirus Genome Replication, Partitioning, and Maintenance in Latency

Ohsaki, E., & Ueda, K. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00007 · Cited by 23

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

Liu, C. F., Brandt, G. S., Hoang, Q. Q., Naumova, N., Lazarevic, V., Hwang, E. S., Dekker, J., Glimcher, L. H., Ringe, D., & Petsko, G. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613914113 · Cited by 23

Positive and Negative Control of Enhancer-Promoter Interactions by Other DNA Loops Generates Specificity and Tunability

Hao, N., Shearwin, K. E., & Dodd, I. B. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.002 · Cited by 25

Quantitation of interactions between two DNA loops demonstrates loop domain insulation in E. coli cells

Priest, D. G., Kumar, S., Yan, Y., Dunlap, D. D., Dodd, I. B., & Shearwin, K. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410764111 · Cited by 23

Three Murine Leukemia Virus Integration Regions within 100 Kilobases Upstream ofc-mybAre Proximal to the 5′ Regulatory Region of the Gene through DNA Looping

Zhang, J., Markus, J., Bies, J., Paul, T. A., & Wolff, L. (2012) · Journal of Virology · doi:10.1128/jvi.01077-12 · Cited by 22

Transthyretin Maintains Muscle Homeostasis through the Novel Shuttle Pathway of Thyroid Hormones during Myoblast Differentiation

Lee, E. J., Shaikh, S., Choi, D., Ahmad, K., Baig, M. H., Lim, J. H., Lee, Y., Park, S. J., Kim, Y., Park, S., et al. (2019) · Cells · doi:10.3390/cells8121565 · Cited by 20

Noncommutative Biology: Sequential Regulation of Complex Networks

Letsou, W., & Cai, L. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005089 · Cited by 21

Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer

Roon, E. H. J. V., de Miranda, N. F. C. C., van Nieuwenhuizen, M. P., de Meijer, E. J., van Puijenbroek, M., Yan, P. S., Huang, T. H. ‐., van Wezel, T., Morreau, H. M., & Boer, J. M. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.187 · Cited by 20

The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo

Cavalieri, V., Melfi, R., & Spinelli, G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003847 · Cited by 20

Gene Specificity of Suppression of Transgene-Mediated Insertional Transcriptional Activation by the Chicken HS4 Insulator

Desprat, R., & Bouhassira, E. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005956 · Cited by 21

Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor

Warwick, T., Schulz, M. H., Gilsbach, R., Brandes, R. P., & Seuter, S. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac178 · Cited by 16

The structural and functional roles of CTCF in the regulation of cell type-specific and human disease-associated super-enhancers

Shin, H. Y. (2018) · Genes & Genomics · doi:10.1007/s13258-018-0768-z · Cited by 17

Histone acetylation contributes to chromatin looping between the locus control region and globin gene by influencing hypersensitive site formation

Kim, Y. W., & Kim, A. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.04.006 · Cited by 18

The logic of native enhancer-promoter compatibility and cell-type-specific gene expression variationPreprint

Narita, T., Higashijima, Y., Kilic, S., Maskey, E., Neumann, K., & Choudhary, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.18.500456 · Cited by 17

CTCF depletion alters chromatin structure and transcription of myeloid-specific factors.

Ouboussad, L., Kreuz, S., & Lefevre, P. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt023 · Cited by 13

The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer

Wang, D., Li, C. L., & Zhang, X. (2014) · DNA and Cell Biology · doi:10.1089/dna.2013.2257 · Cited by 17

Engineering three-dimensional genome folding

Zhang, D., Lam, J. C., & Blobel, G. A. (2021) · Nature Genetics · doi:10.1038/s41588-021-00860-9 · Cited by 17

Multiple CTCF sites cooperate with each other to maintain a TAD for enhancer–promoter interaction in the β‐globin locus

Kang, J. G., Kim, Y. W., Park, S., Kang, Y., & Kim, A. (2021) · The FASEB Journal · doi:10.1096/fj.202100105rr · Cited by 16

Learning representations of chromatin contacts using a recurrent neural network identifies genomic drivers of conformation

Dsouza, K. B., Maslova, A., Al-Jibury, E., Merkenschlager, M., Bhargava, V. K., & Libbrecht, M. W. (2022) · Nature Communications · doi:10.1038/s41467-022-31337-w · Cited by 15

The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

Freeman, D. M., Lou, D. W., Li, Y., Martos, S. N., & Wang, Z. (2020) · Epigenetics & Chromatin · doi:10.1186/s13072-020-00338-8 · Cited by 15

Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome

Oh, E. S., Jeremian, R., Oh, G., Groot, D. E., Susic, M., Lee, K., Foy, K. K., Laird, P. W., Petronis, A., & Labrie, V. (2017) · Scientific Reports · doi:10.1038/srep41843 · Cited by 16

Controlling gene activation by enhancers through a drug-inducible topological insulator

Tsujimura, T., Takase, O., Yoshikawa, M., Sano, E., Hayashi, M., Hoshi, K., Takato, T., Toyoda, A., Okano, H., & Hishikawa, K. (2020) · eLife · doi:10.7554/elife.47980 · Cited by 16

An ectopic CTCF-dependent transcriptional insulator influences the choice of Vβ gene segments for VDJ recombination at TCRβ locus

Shrimali, S., Srivastava, S., Varma, G., Grinberg, A., Pfeifer, K. E., & Srivastava, M. P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks556 · Cited by 14

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts

Vinjamur, D. S., Alhashem, Y. N., Mohamad, S., Amin, P. H., Williams, D. C., & Lloyd, J. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146802 · Cited by 13

Roles of DNA Looping in Enhancer-Blocking Activity

Tokuda, N., Sasai, M., & Chikenji, G. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.11.016 · Cited by 12

Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations

Lu, R., & Rogan, P. K. (2018) · F1000Research · doi:10.12688/f1000research.17363.2 · Cited by 16

Decoding the Equine Genome: Lessons from ENCODE

Peng, S., Petersen, J. L., Bellone, R. R., Kalbfleisch, T., Kingsley, N. B., Barber, A. M., Cappelletti, E., Giulotto, E., & Finno, C. J. (2021) · Genes · doi:10.3390/genes12111707 · Cited by 10

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Smits, W. K., Vermeulen, C., Hagelaar, R., Kimura, S., Vroegindeweij, E. M., Buijs-Gladdines, J. G. C. A. M., van de Geer, E., Verstegen, M. J. A. M., Splinter, E., van Reijmersdal, S. V., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112373 · Cited by 13

Towards a genome-wide reconstruction of cis-regulatory networks in the human genome

Cecchini, K. R., Banerjee, A. R., & Kim, T. H. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.06.005 · Cited by 11

Cutting Edge: Proper Orientation of CTCF Sites in Cer Is Required for Normal Jκ-Distal and Jκ-Proximal Vκ Gene Usage

Kleiman, E., Xu, J., & Feeney, A. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800785 · Cited by 10

Pan-cancer analysis of somatic mutations and epigenetic alterations in insulated neighbourhood boundaries

Pinoli, P., Stamoulakatou, E., Nguyen, A.-P., Martínez, M. R., & Ceri, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227180 · Cited by 11

Factors and Mechanisms That Influence Chromatin-Mediated Enhancer–Promoter Interactions and Transcriptional Regulation

Ito, S., Das, N. D., Umehara, T., & Koseki, H. (2022) · Cancers · doi:10.3390/cancers14215404 · Cited by 13

Form and function of dosage‐compensated chromosomes – a chicken‐and‐egg relationship

Grimaud, C., & Becker, P. B. (2010) · BioEssays · doi:10.1002/bies.201000029 · Cited by 13

Bioinformatics and Translation Elongation

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-032-18842-7_11 · Cited by 9

Transcription-controlling regulatory elements of the eukaryotic genome

Razin, S. V., Gavrilov, A. A., & Ulianov, S. V. (2015) · Molecular Biology · doi:10.1134/s0026893315020119 · Cited by 8

An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference

Fujioka, M., Nezdyur, A., & Jaynes, J. B. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009536 · Cited by 8

Rice RS2‐9, which is bound by transcription factor OSH1, blocks enhancer–promoter interactions in plants

Liu, H., Jiang, L., Wen, Z., Yang, Y., Singer, S. D., Bennett, D., Xu, W., Su, Z., Yu, Z., Cohn, J., et al. (2021) · The Plant Journal · doi:10.1111/tpj.15574 · Cited by 8

The absence of AhR in CD4+ T cells in patients with acute graft-versus-host disease may be related to insufficient CTCF expression

Zeng, C., Cheng, T., Ma, X., Liu, Y., Hua, J., Chen, X., Wang, S., & Xu, Y. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01330-7 · Cited by 7

Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis

Shi, Z., Xu, J., Niu, L., Shen, W., Yan, S., Tan, Y., Quan, X., Cheung, E. C. W., Huang, K., Chen, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112151 · Cited by 7

Long-range DNA interactions are specifically altered by locked nucleic acid-targeting of a CTCF binding site

Ling, J. Q., Hou, A., & Hoffman, A. R. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.11.004 · Cited by 7

Downregulation of p53 by Insufficient CTCF in CD4+ T Cells Is an Important Factor Inducing Acute Graft-Versus-Host Disease

Hua, J., Chen, Y., Fu, B., Chen, X., Xu, X., Yang, S., Chen, C., & Xu, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.568637 · Cited by 7

Distance-Based Phylogenetic Methods

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_15 · Cited by 7

Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites

Chen, W., Zeng, Y. C., Achinger-Kawecka, J., Campbell, E. M., Jones, A. K., Stewart, A. G., Khoury, A., & Clark, S. J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae530 · Cited by 8

Role of Bioinformatics in Drug Design and Discovery

Patel, P. H., JHA, A. N., & Chakraborthy, G. S. (2023) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-99-1316-9_1 · Cited by 6

DNase I Hypersensitivity and ϵ-Globin Transcriptional Enhancement Are Separable in Locus Control Region (LCR) HS1 Mutant Human β-Globin YAC Transgenic Mice

Shimotsuma, M., Okamura, E., Matsuzaki, H., Fukamizu, A., & Tanimoto, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116525 · Cited by 6

Experimental Strategies to Manipulate the Cellular Levels of the Multifunctional Factor CTCF

González-Buendía, E., Pérez‐Molina, R., Ayala-Ortega, E., Guerrero, G., & Targa, F. R. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0856-1_5 · Cited by 6

Two Adhesive Sites Can Enhance the Knotting Probability of DNA

Najafi, S., & Potestio, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132132 · Cited by 6

Spatial Chromatin Architecture Alteration by Structural Variations in Human Genomes at Population ScalePreprint

Sadowski, M., Kraft, A., Szałaj, P., Wlasnowolski, M., Tang, Z., Ruan, Y., & Plewczyński, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/266981 · Cited by 6

Association of DDX5/p68 protein with the upstream erythroid enhancer element (EHS1) of the gene encoding the KLF1 transcription factor

Chen, X., Pillay, S., Lohmann, F., & Bieker, J. J. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105489 · Cited by 5

Genetic variation is associated with RTN4R expression and working memory processing in healthy humans

Bianco, L. L., Attrotto, M. T., Torretta, S., Masellis, R., Rampino, A., D’Ambrosio, E., Giorgio, A. D., Ferranti, L., Fazio, L., Gelao, B., et al. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.07.015 · Cited by 5

Nucleotide Substitution Models and Evolutionary Distances

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_12 · Cited by 5

Modification of Nuclear Compartments and the 3D Genome in the Course of a Viral Infection

Razin, S. V., Gavrilov, A. A., & Iarovaia, O. V. (2020) · Acta Naturae · doi:10.32607/actanaturae.11041 · Cited by 5

Genetic determinants of chromatin accessibility in T cell activation across humansPreprint

Gate, R. E., Cheng, C. S., Aiden, A. P., Siba, A., Tabaka, M., Lituiev, D., Machol, I., Gordon, M. G., Subramaniam, M., Shamim, M., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/090241 · Cited by 7

CTCF blocks anti-sense transcription initiation at divergent gene promotersPreprint

Luan, J. Y., Syrett, C. M., Vermunt, M. W., Coté, A., Tome, J. M., Zhang, H., Huang, A., Luppino, J. M., Keller, C. A., Giardine, B. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.30.465508 · Cited by 5

Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain

Nosova, O., Bazov, I., Karpyak, V. M., Hallberg, M., & Bakalkin, G. Y. (2021) · Molecules · doi:10.3390/molecules26113458 · Cited by 4

Chromatin Structure and Intellectual Disability Syndromes

Elbert, A., & Nathalie, G. (2013) · InTech eBooks · doi:10.5772/55730 · Cited by 4

3D Genomics

Razin, S. V., Ulianov, S. V., & Gavrilov, A. A. (2019) · Molecular Biology · doi:10.1134/s0026893319060153 · Cited by 4

Design of Synthetic Mammalian Promoters Using Highly Palindromic Subsequences

Govorkova, P., Lam, C. K. C., & Truong, K. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00600 · Cited by 3

TAD ‐dependent sub‐ TAD is required for enhancer–promoter interaction enabling the β‐globin transcription

Lee, D., Kang, J., & Kim, A. (2024) · The FASEB Journal · doi:10.1096/fj.202401526rr · Cited by 4

Genomic Features: Content Sensors, Nucleotide Skew Plot, Strand Asymmetry, and DNA Methylation

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_11 · Cited by 3

Bioinformatics and Translation Initiation

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-032-18842-7_10 · Cited by 3

Recent advances in chromosome capture techniques unraveling 3D genome architecture in germ cells, health, and disease

Pandupuspitasari, N. S., Khan, F. A., Huang, C., Ali, A., Yousaf, M. R., Shakeel, F., Putri, E. M., Negara, W., Muktiani, A., Prasetiyono, B. W. H. E., et al. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01146-5 · Cited by 3

Insulators in vertebrates: regulatory mechanisms and chromatin structure

Ulianov, S. V., Markova, E. N., Gavrilov, A. A., & Razin, S. V. (2012) · Biopolymers and Cell · doi:10.7124/bc.000057 · Cited by 3

Protein Isoelectric Point and Helicobacter pylori

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-032-18842-7_14 · Cited by 3

CW198 acts as a genetic insulator to block enhancer-promoter interaction in plants

Jiang, L., Liu, Y., Wen, Z., Yang, Y., Singer, S. D., Bennett, D., Xu, W., Su, Z., Yu, Z., Cohn, J., et al. (2022) · Transgenic Research · doi:10.1007/s11248-022-00326-6 · Cited by 3

Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization

Vaïsänen, S., Matilainen, J. M., & Carlberg, C. (2011) · Dermato-Endocrinology · doi:10.4161/derm.15803 · Cited by 3

Tandem Directional CTCF Sites Balance Protocadherin Promoter UsagePreprint

Wu, Q., Guo, Y., Lu, Y., Li, J., Wu, Y., & Jia, Z. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/525543 · Cited by 3

Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation

Yang, J. H., Pinholt, H. D., Toppen, J., Huseyin, M. K., Jusuf, J. M., Katsifis, C. C., Kæstel-Hansen, J., Mirny, L. A., Zechner, C., & Hansen, A. S. (2026) · doi:10.64898/2026.06.21.733446 · Cited by 3

CTCF ‐Binding Sites Demarcate Chromatin Domains Enriched With Histone H3K9me2 or H3K9me3 and Restrict the Spreading of These Modifications in Human Cells

Shin, K.-J., Kang, J., & Kim, A. (2026) · The FASEB Journal · doi:10.1096/fj.202502813r · Cited by 2

String Mathematics, BLAST, and FASTA

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_1 · Cited by 2

Activation of the Androgen Receptor gene by BORIS/CTCFL in prostate cancer cellsPreprint

Hari‐Gupta, Y., Kita, G.-X., Farrar, D., & Klenova, E. M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/195875 · Cited by 2

An intergenic silencer region regulates HBG expression

Zhu, X., Liu, L., Li, Y., Takezaki, M., Bombin, S., Yu, A., Pendergast, M. A., Sheehan, V., Kuppers, D. A., Bleris, L. G., et al. (2026) · Blood Red Cells & Iron · doi:10.1016/j.brci.2026.100046 · Cited by 1

P2X7 receptor or TNAP genetic blockade prevents the reduction of neuronal CTCF detected in tauopathy

Aivar, P., Sebastián‐Serrano, Á., Vincelle-Nieto, Á., Collado-Cantero, A. C., Corredera, D. O., Soria-Tobar, L., Reyes‐Palomares, A., & Dı́az-Hernández, M. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110948 · Cited by 1

Fundamentals of Proteomics

Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_19 · Cited by 1

Association of Ddx5/p68 protein with the upstream erythroid enhancer element (EHS1) of the Klf1 genePreprint

Chen, X., Pillay, S., Lohmann, F., & Bieker, J. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/743435 · Cited by 1

The conserved DNMT1 dependent methylation regions in human cells are vulnerable to environmental rotenonePreprint

Freeman, D. M., Lou, D. W., Li, Y., Martos, S. N., & Wang, Z. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/798587 · Cited by 1

Effects of CTCF on the regulatory landscape of the mouse Sox2 locusPreprint

Eder, M., Moene, C. J. I., Kaagman, M., Braccioli, L., de Wit, E., & van Steensel, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.16.711995 · Cited by 1

A functional analysis of the epigenetic regulator CTCF

Kitchen, N. S. (2010) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Keeping the genome in shape : a role for protein and RNA

Splinter, E. (2011) · EUR Research Repository (Erasmus University Rotterdam)

REGULATION OF THE MOUSE AND HUMAN β-GLOBIN GENES BY KRÜPPEL LIKE TRANSCRIPTION FACTORS KLF1 AND KLF2

Alhashem, Y. N. (2012) · PubMed Central · doi:10.25772/tpyr-kk74

CTCF (CCCTC-binding factor (zinc finger protein))

Piette, J. (2012) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/46051

Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

Bazov, I. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Computational analysis of ChIP-seq data and its application to the reconstruction of transcriptional regulatory networks

Xu, H. (2011) · doi:10.32657/10356/45765

Biochemical Studies of the CTCF Insulator Protein: Determination of Protein Interactions with CTCF using Tandem Affinity Purification, Characterization of its Post-translational Modification by the Small Ubiquitin-like Modifier Proteins and Studies of CTCF DNA Looping Ability

MacPherson, M. J. (2011) · TSpace (University of Toronto)

Characterization of Drosophila Boundary Element Associated Factor BEAF-32B Interactions with Transcription Factors and Chromatin Remodeling Complexes.

Dong, Y. (2020) · Louisiana State University · doi:10.31390/gradschool_dissertations.5233

Control of Enhancer-Promoter Contact by Alternative DNA LoopsPreprint

Hao, N., Shearwin, K. E., & Dodd, I. B. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3285806

Prodynorphin Epialleles

Bazov, I., & Bakalkin, G. Y. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-29901-3_3

Faculty Opinions recommendation of Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

Neri, G., & Tabolacci, E. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717548117.793003126

Faculty Opinions recommendation of Formation of chromosomal domains by loop extrusion.

Kenter, A. L. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726375416.793558065

Genomic Studies of BEAF-32 in Drosophila

McKowen, J. K. (2021) · doi:10.31390/gradschool_dissertations.5515

Inferring Single-Molecule Chromatin Interactions via Online Convex Network Dictionary LearningPreprint

Peng, J., Pan, C., Lyu, H., Kim, M., Cheng, A. W., & Milenković, O. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.28.501904

DNA binding domain undergoes dynamic and selective protein–protein interactions to facilitate CTCF insulationPreprint

Rong, Z., Tian, K., Jie, H., Duan, W., Fu, H., Feng, Y., Wang, H., Jiang, Y., Yuanjun, L., Wang, R., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.15.491938

Genetics and genomics of early gonad development

Ou, F., Wang, Z., Liao, J., Suen, H. C., Miu, K.-K., & Chan, W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91380-5.00016-2 · Cited by 1

Beyond DNA binding: CTCF at the crossroads of chromatin architecture and epitranscriptomic regulation

Mukherjee, O., & Sarkar, K. (2025) · Epigenomics · doi:10.1080/17501911.2025.2591875

Identifying long-range control elements of the BRCA1 promoter

Lee, J. (2015) · The University of Queensland · doi:10.14264/uql.2015.455

New transcriptional roles for the classic Drosophila insulator protein Suppressor of Hairy-wing

Soshnev, A. A. (2012) · doi:10.17077/etd.potlh8sl

Additional file 1 of Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

Jia, Z., Li, J., Ge, X., Wu, Y., Guo, Y., & Wu, Q. (2020) · Figshare · doi:10.6084/m9.figshare.12211295

Additional file 2 of Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

Jia, Z., Li, J., Ge, X., Wu, Y., Guo, Y., & Wu, Q. (2020) · Figshare · doi:10.6084/m9.figshare.12211298

Additional file 1 of The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

Freeman, D. M., Lou, D. W., Li, Y., Martos, S. N., & Wang, Z. (2020) · Figshare · doi:10.6084/m9.figshare.11992554

Human β-Globin Locus Control Region HS5Contains CTCF- and Developmental Stage-Dependent Enhancer-BlockingActivity in ErythroidCells

Tanimoto, K., Sugiura, A., Omori, A., Felsenfeld, G., Engel, J. D., & Fukamizu, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.8946-8952.2003 · Cited by 55

Enhancer Blocking by Chicken β-Globin 5′-HS4

Zhao, H., Kim, A., Song, S., & Dean, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606803200 · Cited by 20

Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci

Farrell, C. M., West, A. G., & Felsenfeld, G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3820-3831.2002 · Cited by 184

Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

Targa, F. R., Pikaart, M. J., Burgess-Beusse, B. L., Bell, A. C., Litt, M. D., West, A. G., Gaszner, M., & Felsenfeld, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102179399 · Cited by 381

Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

Li, Q., & Stamatoyannopoulos, G. (1994) · Blood · doi:10.1182/blood.v84.5.1399.1399 · Cited by 111