New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

Zecca, Luigi, Bellei, Chiara, Costi, Patrizia, Albertini, Alberto, Monzani, Enrico, Casella, Luigi, Gallorini, Mario, Bergamaschi, Luigi +10 more·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0808768105

Cited by (240)

Items 101–200 of 240

Copper‐Aβ Peptides and Oxidation of Catecholic Substrates: Reactivity and Endogenous Peptide Damage
Valentina Pirota, Simone Dell’Acqua, Enrico Monzani, Stefania Nicolis, Luigi Casella · 2016 · Chemistry - A European Journal
Paraquat–Melanin Redox-Cycling: Evidence from Electrochemical Reverse Engineering
Eunkyoung Kim, W. Taylor Leverage, Yi Liu, Lucia Panzella, Maria Laura Alfieri, Alessandra Napolitano, William E. Bentley, Gregory Francis Payne · 2016 · ACS Chemical Neuroscience
Catecholamines and Parkinson’s disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview
Toshiharu Nagatsu · 2023 · Journal of Neural Transmission
Lewy pathology formation in patient-derived GBA1 Parkinson’s disease midbrain organoids
Emanuele Frattini, Gaia Faustini, Gianluca Lopez, Emma Veronica Carsana, Mattia Tosi, Ilaria Trezzi, Manuela Magni, Giulia Soldà, Letizia Straniero, Daniele Facchi et al. · 2024 · Brain
Modern Brainstem MRI Techniques for the Diagnosis of Parkinson's Disease and Parkinsonisms
Germain Arribarat, Amaury De Barros, Patrice Péran · 2020 · Frontiers in Neurology
Melanin-Based Coatings as Lead-Binding Agents
Karin Sono, Diane S. Lye, Christine A. Moore, Warren Christopher Boyd, Thomas A. Gorlin, Jason M. Belitsky · 2012 · Bioinorganic Chemistry and Applications
Dopamine Metabolism and Reactive Oxygen Species Production
Sylvie Delcambre, Yannic Nonnenmacher, Karsten Hiller · 2016 · Springer eBooks
Recyclable One-Step Extraction and Characterization of Intact Melanin from Alpaca Fibers
Yujia Liang, Qi Han, Nolene Byrne, Lu Sun, Xungai Wang · 2018 · Fibers and Polymers
DOPA pheomelanin is increased in nigral neuromelanin of Parkinson’s disease
Waijiao Cai, Kazumasa Wakamatsu, Fabio Andrea Zucca, Qing Wang, Kai Yang, Niyaz Mohammadzadeh Honarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella et al. · 2023 · Progress in Neurobiology
Distinct Types of Lipofuscin Pigment in the Hippocampus and Cerebellum of Aged Cheirogaleid Primates
Emmanuel Gilissen, L. Staneva-Dobrovski · 2013 · The Anatomical Record
The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites
Shosuke Ito, Yuta Yamanaka, Makoto Ojika, Kazumasa Wakamatsu · 2016 · International Journal of Molecular Sciences
An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson’s disease using neuromelanin-sensitive MRI
Qiang Liu, Pan Wang, Chenghe Liu, Feng Xue, Qian Wang, Yuqing Chen, Ruihua H. Hou, Teng Chen · 2023 · BMC Neurology
The Oxidative Pathway to Dopamine–Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson’s Disease
Kazumasa Wakamatsu, Kenta Nakao, Hitomi Tanaka, Yuki Kitahori, Yui Tanaka, Makoto Ojika, Shosuke Ito · 2019 · International Journal of Molecular Sciences
Label‐Free Nanoimaging of Neuromelanin in the Brain by Soft X‐ray Spectromicroscopy
Jake Brooks, James L. Everett, Frederik Lermyte, Vindy Tjendana Tjhin, Samya Banerjee, Peter B. O’Connor, Christopher M. Morris, Peter John Sadler, Neil D. Telling, Joanna F. Collingwood · 2020 · Angewandte Chemie International Edition
Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin
Kazumasa Wakamatsu, Hitomi Tanaka, Keisuke Tabuchi, Makoto Ojika, Fabio Andrea Zucca, Luigi Zecca, Shosuke Ito · 2014 · Molecules
γ-Glutamylamines and neurodegenerative diseases
Thomas M. Jeitner, K.P. Battaile, Arthur J.L. Cooper · 2012 · Amino Acids
Nano-Scale Morphology of Melanosomes Revealed by Small-Angle X-Ray Scattering
Thomas Gorniak, Tamás Haraszti, Vasyl M. Garamus, Andreas R. Buck, Tobias Senkbeil, Marius Priebe, Adam Hedberg‐Buenz, Demelza Koehn, Tim Salditt, M. Grunze et al. · 2014 · PLoS ONE
RETRACTED ARTICLE: Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression
Kenneth Wengler, Brandon K. Ashinoff, Elena Pueraro, Clifford Cassidy, Guillermo Horga, Bret R. Rutherford · 2020 · Neuropsychopharmacology · Retracted
Melanin: a unifying theory of disease as exemplified by Parkinson’s, Alzheimer’s, and Lewy body dementia
Stacie Z. Berg, Jonathan Berg · 2023 · Frontiers in Immunology
Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress
Simone Dell’Acqua, Chiara Bacchella, Enrico Monzani, Stefania Nicolis, Giuseppe Di Natale, Enrico Rizzarelli, Luigi Casella · 2017 · Inorganic Chemistry
Cross-Scanner Harmonization of Neuromelanin-Sensitive MRI for Multisite Studies
Kenneth Wengler, Clifford Cassidy, M. van der Pluijm, J. Weinstein, A. Abi-Dargham, E. M. van de Giessen, Guillermo Horga · 2021 · Journal of Magnetic Resonance Imaging
Pool size ratio of the substantia nigra in Parkinson’s disease derived from two different quantitative magnetization transfer approaches
Paula Trujillo, Paul Eugene Summers, Alex K. Smith, Seth A. Smith, Luca Tommaso Mainardi, S. Cerutti, Daniel O. Claassen, Antonella Costa · 2017 · Neuroradiology
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
Leslie Hassanein, Bernard Mulvey, Harris E. Blankenship, Margaret Tish, Anu Korukonda, L. Cameron Liles, Amanda Lea Sharpe, Jean‐François Paré, Rosa M. Villalba, Xiangchuan Chen et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Iron and copper ions accelerate and modify dopamine oxidation to eumelanin: implications for neuromelanin genesis
Shosuke Ito, Alessandra Napolitano, Tadeusz Sarna, Kazumasa Wakamatsu · 2022 · Journal of Neural Transmission
Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging
Dmitriy E. Korzhevsky, Olga V. Kirik, В. В. Гусельникова, Д. Л. Цыба, Elena A. Fedorova, I. P. Grigor’ev · 2021 · European Journal of Histochemistry
Chemiexcitation: Mammalian Photochemistry in the Dark<sup>†</sup>
Brash, Douglas E., Goncalves, Leticia C. P. · 2023 · Photochemistry and Photobiology
Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids
Weslyn C. Ward, Fabio Andrea Zucca, Chiara Bellei, Luigi Zecca, John D. Simon · 2009 · Archives of Biochemistry and Biophysics
Tobramycin Promotes Melanogenesis by Upregulating p38 MAPK Protein Phosphorylation in B16F10 Melanoma Cells
Seung-Hyun Moon, You Chul Chung, Chang‐Gu Hyun · 2019 · Antibiotics
Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis
Marisleydis García Saborit, Alejandro Jara, Néstor Muñoz, Carlos Milovic, Ángeles Tepper, Luz María Alliende, Carlos Mena, Bárbara Iruretagoyena, Juan Pablo Ramírez-Mahaluf, Camila Díaz et al. · 2023 · Schizophrenia Bulletin
Ferroptosis—A Shared Mechanism for Parkinson’s Disease and Type 2 Diabetes
Carmen Duţă, Corina Muscurel, Carmen Beatrice Dogaru, Irina Anna-Maria Stoian · 2024 · International Journal of Molecular Sciences
Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
J. Pérot, Anthony Ruze, Rahul Gaurav, Sana Rebbah, Capucine Cadin, Arnaud Le Troter, Lucas Soustelle, Laura Mouton, Romain Valabrègue, Annabelle Parent et al. · 2025 · Brain Communications
Current Challenges in Understanding the Story of Skin Pigmentation — Bridging the Morpho-Anatomical and Functional Aspects of Mammalian Melanocytes
Sharique A. Ali, Ishrat Naaz · 2015 · InTech eBooks
Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention
Shaina L. Rosenblum, Daniel J. Kosman · 2022 · Frontiers in Neurology
Oxidative Stress in Parkinson's Disease
Jacob Vaya, Yuval Aluf, John P.M. Finberg · 2010 · Humana Press eBooks
Ferritin and neuromelanin “quantum dot” array structures in dopamine neurons of the substantia nigra pars compacta and norepinephrine neurons of the locus coeruleus
Christopher John Rourk · 2018 · Biosystems
Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra
Xue Ling Liu, Li Yang, Feng Tao Liu, Pu‐Yeh Wu, Yong Zhang, Han Zhuang, Yong Shi, Jian Wang, Dao Ying Geng, Yu Xin Li · 2020 · BMC Neurology
Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra
G. Salzman, Jocelyn Kim, Guillermo Horga, Kenneth Wengler · 2021 · Journal of Visualized Experiments
Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome
Sarah Plum, Simone Steinbach, Laura Abel, Katrin Marcus, Stefan Helling, Caroline May · 2014 · PROTEOMICS - CLINICAL APPLICATIONS
Melanins in Vertebrates
Kazumasa Wakamatsu, Shosuke Ito · 2021 · Springer eBooks
Magnetic resonance imaging of the dopamine system in schizophrenia – A scoping review
Schulz, Julia, Zimmermann, Juliana, Sorg, Christian, Menegaux, Aurore, Brandl, Felix · 2022 · Frontiers in Psychiatry
Speciation Analysis of Gadolinium in the Water-Insoluble Rat Brain Fraction After Administration of Gadolinium-Based Contrast Agents
Izabela Strzeminska, Cécile Factor, Philippe Robert, Joanna Szpunar, Claire Corot, Ryszard Łobiński · 2021 · Investigative Radiology
A reappraisal of Fe(III) adsorption by melanin
R.L. Schroeder, Cobus Gerber · 2014 · Journal of Neural Transmission
Tau Tangles in Parkinson’s Disease: A 2-Year Follow-Up Flortaucipir PET Study
Allan K. Hansen, Peter Parbo, Rola Ismail, Karen Østergaard, David James Brooks, Per Borghammer · 2019 · Journal of Parkinson s Disease
Mimicking neuromelanin nanoparticles as a selective Pb2+ probe
Shu Zhang, Ming Xiao, Yuqian Zhang, Yang Li, Huan Li Liu, Gang Han, Brijesh Rathi, Kaiyu Lyu, Lidong Wu · 2020 · Analytica Chimica Acta
Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology
Fatema Currim, Reeya Tanwar, Josephine M. Brown-Leung, Neha Paranjape, Jennifer Liu, Laurie H. Sanders, Jonathan A. Doorn, Jason R. Cannon · 2024 · NeuroToxicology
Reduced Brain Iron and Striatal Hyperdopaminergia in Schizophrenia: A Quantitative Susceptibility Mapping MRI and PET Study
Luke James Vano, Robert Ali McCutcheon, Jan Sedlacik, Stephen John Kaar, Grazia Rutigliano, Giovanna Nordio, Valeria Finelli, Leigh Townsend, Alaine Berry, Ben K. Statton et al. · 2025 · American Journal of Psychiatry
Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue
Marta González-Sepúlveda, Ariadna Laguna, Iria Carballo‐Carbajal, Jordi Galiano-Landeira, Jordi Romero‐Giménez, Thaïs Cuadros, Annabelle Parent, Núria Peñuelas, Joan Compte, Alba Nicolau et al. · 2020 · ACS Chemical Neuroscience
Inflaming the diseased brain: a role for tainted melanins
Thomas M. Jeitner, Mike Kalogiannis, Patricia A. Patrick, Irving H. Gomolin, Thomas A. Palaia, Louis Ragolia, Donald A. Brand, Edward J. Delikatny · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
The expanding role and presence of neuromelanins in the human brain – why gray matter is gray
Vincent J. Hearing · 2008 · Pigment Cell & Melanoma Research
Transition metals and trace elements in the retinal pigment epithelium and choroid: correlative ultrastructural and chemical analysis by analytical electron microscopy and nano-secondary ion mass spectrometry
Antje Biesemeier, O. Eibl, Santhana Eswara, Jean‐Nicolas Audinot, Tom Wirtz, Ulrich Schraermeyer · 2017 · Metallomics
Water‐Soluble Melanin–Protein–Fe/Cu Conjugates Derived from Norepinephrine as Reliable Models for Neuromelanin of Human Brain Locus Coeruleus
Andrea Capucciati, Enrico Monzani, Michela Sturini, Stefania Nicolis, Fabio Andrea Zucca, Luigi Bubacco, Marco Bortolus, Luigi Zecca, Luigi Casella · 2022 · Angewandte Chemie International Edition
Understanding the way eumelanin works: A unique example of properties and skills driven by molecular heterogeneity
Maria Letizia Terranova, Emanuela Tamburri · 2021 · Polymer
Ferroptosis inhibition protects against α-synuclein-related neuronal cell death
Nad’a Majerníková, Maria João da Costa Caiado, Renée I. Seinstra, Suzanne Couzijn, María Eugenia Goya, Casandra Salinas Salinas, Hannah Truong, Tineke van der Sluis, Anneke Miedema, Léon C.L.T. van Kempen et al. · 2025 · Cell Death and Disease
Advancements in understanding substantia nigra hyperechogenicity via transcranial sonography in Parkinson’s disease and its clinical implications
Yuan-yuan Zhang, Xuhong Jiang, Pei-pei Zhu, Wenyan Zhuo, Li-bin Liu · 2024 · Frontiers in Neurology
Polysaccharide-Mediated Synthesis of Melanins from Serotonin and Other 5-Hydroxy Indoles
Koen P. Vercruysse, Astiney M. Clark, Noor Alatas, Dylan Brooks, Nafisa Hamza, Margaret M. Whalen · 2018 · Future Science OA
Diversity of melanin synthesis genes in insects
Ryo Futahashi, Shigeyuki Koshikawa, Genta Okude, Mizuko Osanai-Futahashi · 2022 · Advances in insect physiology
Amount of Melanin Granules in Human Hair Defines the Absorption and Conversion to Heat of Light Energy in the Visible Spectrum
Joshua A Roldán-Kalil, Lidia V. Zueva, Janaína M. Alves, Vassiliy Tsytsarev, Priscila Sanabria, Mikhail Y. Inyushin · 2022 · Photochemistry and Photobiology
Carnosine Protects Against the Neurotoxic Effects of a Serotonin-Derived Melanoid
Tanner D. Brownrigg, Christopher Shane Theisen, Eugene E. Fibuch, Norbert W. Seidler · 2010 · Neurochemical Research
Melanin-Binding Colorants: Updating Molecular Modeling, Staining and Labeling Mechanisms, and Biomedical Perspectives
JUAN CARLOS STOCKERT, Jesús Espada, Alfonso Blázquez‐Castro · 2022 · Colorants
Striatal dopamine synthesis capacity and neuromelanin in the substantia nigra: A multimodal imaging study in schizophrenia and healthy controls
C. V. van Hooijdonk, M. van der Pluijm, Charlotte L C Smith, M. Yaqub, F. V. van Velden, G. Horga, Kenneth Wengler, M. Hoven, R. V. van Holst, L. de Haan et al. · 2023 · Neuroscience Applied
Exploiting Principal Component Analysis (PCA) to reveal temperature, buffer and metal ions' role in neuromelanin (NM) synthesis by dopamine (DA) oxidative polymerization
Fabio Schifano, Lisa Rita Magnaghi, Enrico Monzani, Luigi Casella, Raffaela Biesuz · 2024 · Journal of Inorganic Biochemistry
Neuromelanin-sensitive MRI correlates of cognitive and motor function in Parkinson's disease with freezing of gait
Daniel E. Huddleston, Xiangchuan Chen, Kristy Hwang, Jason A. Langley, Richa Tripathi, Kelsey A. Tucker, J. Lucas McKay, Xiaoping Philip Hu, Stewart Alan Factor · 2023 · Frontiers in Dementia
Oxidation of dopamine and related catechols in dopaminergic brain regions in Parkinson’s disease and during ageing in non-Parkinsonian subjects
Bodil Fornstedt · 2024 · Journal of Neural Transmission
Dopamin, oxidativer Stress und Protein‐Chinonmodifikationen bei Parkinson und anderen neurodegenerativen Erkrankungen
Enrico Monzani, Stefania Nicolis, Simone Dell’Acqua, Andrea Capucciati, Chiara Bacchella, Fabio Andrea Zucca, Eugene V. Mosharov, David L. Sulzer, Luigi Zecca, Luigi Casella · 2018 · Angewandte Chemie
Physiological Roles of Eumelanin- and Melanogenesis-Associated Diseases: A Look at the Potentialities of Engineered and Microbial Eumelanin in Clinical Practice
Maria Letizia Terranova · 2024 · Bioengineering
Determination of metal elements concentrations in human brain tissues using PIXE and EDX methods
Ján Pánik, Martin Kopáni, Jakub Zeman, Miroslav Jeskovsky, Jakub Kaizer, Pavel P. Povinec · 2018 · Journal of Radioanalytical and Nuclear Chemistry
Biomedical overview of melanin. 2. Updating molecular modeling, synthesis mechanism, and supramolecular properties regarding melanoma therapy
JUAN CARLOS STOCKERT, ALFONSO BL罿QUEZ-CASTRO · 2022 · Biocell
TSEREBRALNYYE NARUSHENIYA OBMENA ZHELEZA KAK OSNOVA RAZVITIYA I PROGRESSIROVANIYA NEYRODEGENERATIVNYKH ZABOLEVANIY
Igor Litvinenko, Красаков Игорь Вячеславович, Artem G. Trufanov · 2018 · Bulletin of the Russian Military Medical Academy
Additional comments to “Potential health consequences of applying mercury-containing skin-lightening creams during pregnancy and lactation periods”
Dórea, José G. · 2016 · International Journal of Hygiene and Environmental Health
Comparison of automated and manual quantification methods for n euromelanin‐sensitive MRI in Parkinson's disease
Nicholas A. Shaff, Erik Barry Erhardt, Stephanie R. Nitschke, Kayla R. Julio, Christopher J. Wertz, Andrei A. Vakhtin, Arvind Caprihan, Gerson Suarez‐Cedeño, Amanda Deligtisch, Sarah Pirio Richardson et al. · 2023 · Human Brain Mapping
Dopamine oxidation to neuromelanin and neurotoxic metabolites
Juan Segura‐Aguilar · 2021 · Elsevier eBooks
Illuminating the brain: Revealing brain biochemistry with synchrotron X-ray spectromicroscopy
James L. Everett, Jake Brooks, Frederik Lermyte, Vindy Tjendana Tjhin, Ian Hands-Portman, Emily Hill, Joanna F. Collingwood, Neil D. Telling · 2023 · Journal of Electron Spectroscopy and Related Phenomena
High-fat diet and related obesity provoke neurotoxins and alter neuro-biomarkers involved in Parkinson's disease
Nour Batarseh, Yazan Al Thaher · 2023 · Obesity Medicine
Development of a Competition-Binding Assay to Determine Binding Affinity of Molecules to Neuromelanin via Fluorescence Spectroscopy
Jackson Fink, Heather Pathak, John M. Smith, Cindy Achat‐Mendes, Robert L. Haining · 2019 · Biomolecules
An Electrochemical Study on the Effect of Metal Chelation and Reactive Oxygen Species on a Synthetic Neuromelanin Model
Ri Xu, Francesca Soavi, Clara Santato · 2019 · Frontiers in Bioengineering and Biotechnology
Biological Role of Neuromelanin in the Human Brain and Its Importance in Parkinson's Disease
Kay L. Double, Wakako Maruyama, M. Naoi, Manfred Gerlach, Peter Franz Riederer · 2011
Imaging of Cerebral Iron as an Emerging Marker for Brain Aging, Neurodegeneration, and Cerebrovascular Diseases
C. Zhou, Yi‐Cheng Zhu · 2025 · Brain Sciences
Mitochondrial dysfunction, iron accumulation, and ferroptosis in Parkinson’s disease
Nahom Teferi, Meron Challa, Timothy R. Woodiwiss, Bryan G. Allen, Michael S. Petronek · 2023 · Redox Experimental Medicine
Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules
Antonino Natalello, Stefania Brocca, Erika Ponzini, Carlo Santambrogio, Rita Grandori · 2023 · Frontiers in Bioscience-Landmark
Genetically encoded dihydroxyphenylalanine coupled with tyrosinase for strain promoted labeling
Augustine George, Mohan Indhu, Sundarapandian Ashokraj, Ganesh Shanmugam, Ganesan Ponesakki, Numbi Ramudu Kamini, Niraikulam Ayyadurai · 2021 · Bioorganic & Medicinal Chemistry
Suboptimal foraging decisions and involvement of the ventral tegmental area in human opioid addiction
Candace M. Raio, Kathryn Biernacki, Ananya Kapoor, Kenneth Wengler, Darla Bonagura, Joany Xue, Sara Madureira Constantino, Guillermo Horga, Anna B. Konova · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Neuromelanin-induced cellular stress and neurotoxicity in the pathogenesis of Parkinson's disease
Md. Jakaria, Jason R. Cannon · 2025 · APOPTOSIS
In Situ Magnetometry of Iron in Human Dopaminergic Neurons Using Superresolution MRI and Ion-Beam Microscopy
Malte Brammerloh, Renat Sibgatulin, Karl‐Heinz Herrmann, Markus Morawski, T. Reinert, Carsten Jäger, Roland Müller, Gerald Falkenberg, Dennis Brückner, Kerrin Pine et al. · 2024 · Physical Review X
Catecholaminergic Cell Lines for the Study of Dopamine Metabolism and Neurotoxicity
Juan Segura‐Aguilar · 2011 · Neuromethods
Prominent Roles and Conflicted Attitudes of Eumelanin in the Living World
Maria Letizia Terranova · 2023 · International Journal of Molecular Sciences
Updating melanoma therapy regarding melanin structure: Advances and proposals from biophysics, histochemistry and cell biology
JUAN CARLOS STOCKERT, Alfonso Blázquez‐Castro · 2026 · Acta Histochemica
Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio Andrea Zucca, Enrico Monzani et al. · 2025 · Angewandte Chemie International Edition
Functional neural electron transport
Christopher John Rourk · 2020 · Advances in quantum chemistry
Advances in magnetic resonance imaging
Heather Wilson, Edoardo Rosario de Natale, Marios Politis · 2022 · Elsevier eBooks
Regional age-related changes of neuromelanin and iron in the substantia nigra based on neuromelanin accumulation and iron deposition
Yufan Chen, Tao Gong, Cong Sun, Aocai Yang, Fei Gao, Tong Chen, Weibo Chen, Guangbin Wang · 2023 · European Radiology
Induction of Ferroptotic Cell Death by Neuromelanin Pigments in Dopaminergic Cells
Gizem Kaftan, Güliz Armağan · 2025 · ACS Chemical Neuroscience
Hemispheric Asymmetry of Neuromelanin‐Iron Dysfunction in the Substantia Nigra: MRI ‐Based Evidence for Lateralized Motor Onset in Early‐Stage Parkinson's Disease
Xueling Liu, Na Wang, MinJia Xie, Liqin Yang, Pu‐Yeh Wu, FengTao Liu, Yuxin Li · 2025 · Journal of Magnetic Resonance Imaging
Toxicity of a serotonin-derived neuromelanin
Elizabeth D. Miller, Eugene E. Fibuch, Norbert W. Seidler · 2009 · Biochemical and Biophysical Research Communications
The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease
Fatemeh Farahani, Christelle Anaclet, Hossein Azizi, Heinrich S. Gompf · 2025 · Frontiers in Aging Neuroscience
Copper, Ceruloplasmin, Zinc, and Manganese Levels in Brain and Biological Fluids from Parkinson’s Disease Patients: Systematic Review and Meta-Analysis
F J Jiménez-Jiménez, Hortensia Alonso‐Navarro, Elena García‐Martín, Miguel Ángel Martín-Gómez, Paula Salgado-Cámara, Alba Cárcamo-Fonfría, Margarita Arroyo-Solera, José A. G. Agúndez · 2026 · Cells
Molecular and Neurochemical Mechanisms Dopamine Oxidation To O-Quinones in Parkinson’s Disease Pathogenesis
Patricia Muñoz, Catalina Meléndez, Irmgard B. Paris, Juan Segura‐Aguilar · 2015 · Current topics in neurotoxicity
Unravelling the Parkinson’s puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies
Krishnapriya Chandrababu, Vineeth Radhakrishnan, A S Anjana, Rahul S. Rajan, Unnikrishnan Sivan, Syam Krishnan, P. S. Baby Chakrapani · 2023 · Experimental Brain Research
Evidence for Dopamine Abnormalities Following Acute Methamphetamine Exposure Assessed by Neuromelanin-Sensitive Magnetic Resonance Imaging
Fei Tang, Hui Liu, Xiao Jie Zhang, Hui Zheng, Yong Ming Dai, Li Yun Zheng, Wen Han Yang, Yan Yao Du, Jun Liu · 2022 · Frontiers in Aging Neuroscience
Multiparametric analysis based on 18F-AV133 PET/MR imaging for clinical application in Parkinson’s disease
Yansong Liu, Mengjiao Wang, Wei Han, Xinghe Guan, Zeyu Wang, Shibo Guo, Peng Fu · 2025 · European Journal of Radiology
Test-retest reliability of template-defined vs. manual tracing processing streams in neuromelanin-sensitive magnetic resonance imaging analysis
Tyler A. Lesh, Jason Smucny, Joshua P. Rhilinger, Sarvenaz Pakzad, Guillermo Horga, Cameron S. Carter · 2025 · Neuroimage Reports