New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

Functional amyloid – from bacteria to humans

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The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

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Structures for amyloid fibrils

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Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

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The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

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Dopaminergic Neurons Intrinsic to the Primate Striatum

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Aspects on human amyloid forms and their fibril polypeptides

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Is the Vulnerability of Neurons in the Substantia Nigra of Patients with Parkinson's Disease Related to Their Neuromelanin Content?

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Neurotoxicity of organomercurial compounds

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Interaction of neuromelanin and iron in substantia nigra and other areas of human brain

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Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson’s Disease

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The structure of neuromelanin as studied by chemical degradative methods

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Iron and Other Metals in Neuromelanin, Substantia Nigra, and Putamen of Human Brain

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Primate neostriatal neurons containing tyrosine hydroxylase: Immunohistochemical evidence

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The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface

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The Neuromelanin of Human Substantia Nigra: Physiological and Pathogenic Aspects

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Chemical degradation of melanins: Application to identification of dopamine-melanin

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Comparative analysis of proneural gene expression in the embryonic cerebellum

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Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter‐2: Human midbrain dopamine neurons

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Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: Accumulation in neuromelanin

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Interaction of Human Substantia Nigra Neuromelanin with Lipids and Peptides

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Tyrosinase: a developmentally specific major determinant of peripheral dopamine

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Rett Syndrome - an update

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Effects of Methyl Mercury in Postnatal Developing Rats

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Tyrosine hydroxylase and aromatic l-amino acid decarboxylase do not coexist in neurons in the human anterior cingulate cortex

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Vitamin C Deficiency Facilitates 5‐S‐Cysteinyldopamine Formation in Guinea Pig Striatum

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Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain

Ward, W. C., Guan, Z., Zucca, F. A., Fariello, R. G., Kordestani, R., Zecca, L., Raetz, C. R. H., & Simon, J. D. (2007) · Journal of Lipid Research · doi:10.1194/jlr.c700008-jlr200 · Cited by 33 · see citing works

Decreased nigral neuromelanin in Alzheimer's disease

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Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation

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The role of iron in brain ageing and neurodegenerative disorders

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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., et al. (2017) · Science · doi:10.1126/science.aam9080 · Cited by 874 · see citing works

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

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Protective and toxic roles of dopamine in Parkinson's disease

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Biological metals and metal-targeting compounds in major neurodegenerative diseases

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Melanins and melanogenesis: from pigment cells to human health and technological applications

d’Ischia, M., Wakamatsu, K., Cicoira, F., Mauro, E. D., García-Borrón, J. C., Commo, S., Galván, I., Ghanem, G., Kenzo, K., Meredith, P., et al. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12393 · Cited by 491 · see citing works

Current challenges in understanding melanogenesis: Bridging chemistry, biological control, morphology, and function

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MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Cebrián, C., Zucca, F. A., Mauri, P., Steinbeck, J. A., Studer, L., Scherzer, C. R., Kanter, E., Budhu, S., Mandelbaum, J., Vonsattel, J. P., et al. (2014) · Nature Communications · doi:10.1038/ncomms4633 · Cited by 338 · see citing works

Iron in Neurodegeneration – Cause or Consequence?

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What are melanocytesreallydoing all day long…?

Plonka, P. M., Passeron, T., Brenner, M., Tobin, D. J., Shibahara, S., Thomas, A. J., Slominski, A. T., Kadekaro, A. L., Hershkovitz, D., Peters, E. M. J., et al. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00912.x · Cited by 296 · see citing works

From Extraction to Advanced Analytical Methods: The Challenges of Melanin Analysis

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Determination of Melanin Synthetic Pathways

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Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson’s disease

Sulzer, D. L., Cassidy, C., Horga, G., Kang, U. J., Fahn, S., Casella, L., Pezzoli, G., Langley, J. A., Hu, X. P., Zucca, F. A., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0047-3 · Cited by 277 · see citing works

Dopamine, Oxidative Stress and Protein–Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases

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Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

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Neuromelanin of the Human Substantia Nigra: An Update

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Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging

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Quantification and Assessment of the Chemical Form of Residual Gadolinium in the Brain After Repeated Administration of Gadolinium-Based Contrast Agents

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Iron, myelin, and the brain: neuroimaging meets neurobiology

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Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

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Melanin nanoparticles as a promising tool for biomedical applications – a review

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Melanin-based flexible supercapacitors

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The Aging of Iron Man

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Cerebral Iron Deposition in Neurodegeneration

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Chemical Reactivities of ortho-Quinones Produced in Living Organisms: Fate of Quinonoid Products Formed by Tyrosinase and Phenoloxidase Action on Phenols and Catechols

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Contrast mechanisms associated with neuromelanin‐MRI

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Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease

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Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies

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Disentangling eumelanin “black chromophore”: Visible absorption changes as signatures of oxidation state- and aggregation-dependent dynamic interactions in a model water-soluble 5,6-dihydroxyindole polymer

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Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase

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Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration

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Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats

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Effect of Off-Target Binding on ¹⁸F-Flortaucipir Variability in Healthy Controls Across the Life Span

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<i>In vivo</i>imaging of neuromelanin in Parkinson’s disease using¹⁸F-AV-1451 PET

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Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment

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Engineered nanoparticles, How brain friendly is this new guest?

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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with ¹⁸F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles

Lohith, T. G., Bennacef, I., Vandenberghe, R., Vandenbulcke, M., Salinas, C. A., Declercq, R., Reynders, T., Telan-Choing, N. F., Riffel, K., Celen, S., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.208215 · Cited by 107 · see citing works

Life span pigmentation changes of the substantia nigra detected by neuromelanin‐sensitive MRI

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MRI biomarkers of motor and non-motor symptoms in Parkinson's disease

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Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

Calderón‐Garcidueñas, L., González-Maciel, A., Reynoso-Robles, R., Hammond, J., Kulesza, R. J., Lachmann, I., Torres‐Jardón, R., Mukherjee, P. S., & Maher, B. A. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110139 · Cited by 96 · see citing works

Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders

Wise, R. M., Wagener, A., Fietzek, U. M., Klopstock, T., Mosharov, E. V., Zucca, F. A., Sulzer, D. L., Zecca, L., & Burbulla, L. F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105920 · Cited by 95 · see citing works

Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation

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Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration

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Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

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Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

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Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses

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Neuromelanins of Human Brain Have Soluble and Insoluble Components with Dolichols Attached to the Melanic Structure

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DNAJC12 and dopa‐responsive nonprogressive parkinsonism

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Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the <i>locus coeruleus</i>

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Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.

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