The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
Open accessAbstract
Embryonic stem cells have potential utility in regenerative medicine because of their pluripotent characteristics. Sall4, a zinc-finger transcription factor, is expressed very early in embryonic development with Oct4 and Nanog, two well-characterized pluripotency regulators. Sall4 plays an important role in governing the fate of stem cells through transcriptional regulation of both Oct4 and Nanog. By using chromatin immunoprecipitation coupled to microarray hybridization (ChIP-on-chip), we have mapped global gene targets of Sall4 to further investigate regulatory processes in W4 mouse ES cells. A total of 3,223 genes were identified that were bound by the Sall4 protein on duplicate assays with high confidence, and many of these have major functions in developmental and regulatory pathways. Sall4 bound approximately twice as many annotated genes within promoter regions as Nanog and approximately four times as many as Oct4. Immunoprecipitation revealed a heteromeric protein complex(es) between Sall4, Oct4, and Nanog, consistent with binding site co-occupancies. Decreasing Sall4 expression in W4 ES cells decreases the expression levels of Oct4, Sox2, c-Myc, and Klf4, four proteins capable of reprogramming somatic cells to an induced pluripotent state. Further, Sall4 bound many genes that are regulated in part by chromatin-based epigenetic events mediated by polycomb-repressive complexes and bivalent domains. This suggests that Sall4 plays a diverse role in regulating stem cell pluripotency during early embryonic development through integration of transcriptional and epigenetic controls.
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Self-citationA bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Self-citationMurine inner cell mass-derived lineages depend on Sall4 function
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Cited by
Role of Oct4 in maintaining and regaining stem cell pluripotency
Shi, G., & Jin, Y. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt39 · Cited by 294
Cancer Stem Cell Hierarchy in Glioblastoma Multiforme
Bradshaw, A., Wickremsekera, A., Tan, S. T., Peng, L., Davis, P. F., & Itinteang, T. (2016) · Frontiers in Surgery · doi:10.3389/fsurg.2016.00021 · Cited by 258
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., & Yamanaka, S. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01301.x · Cited by 154
A Novel SALL4/OCT4 Transcriptional Feedback Network for Pluripotency of Embryonic Stem Cells
Yang, J., Gao, C., Chai, L., & Ma, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010766 · Cited by 152
Self-citationThe transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma
Zeng, S. S., Yamashita, T., Kondo, M., Nio, K., Hayashi, T., Hara, Y., Nomura, Y., Yoshida, M., Hayashi, T., Oishi, N., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.024 · Cited by 140
Metadata
- Authors
- Yang, J., Chai, L., Fowles, T. C., Alipio, Z., Xu, D., Fink, L. M., Ward, D. C., & Ma, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-12-16
- Volume
- 105
- Issue
- 50
- Pages
- 19756-19761
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005601940
- Cited by
- 202
- References
- 10
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, J., Chai, L., Fowles, T. C., Alipio, Z., Xu, D., Fink, L. M., Ward, D. C., & Ma, Y. (2008). Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0809321105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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