The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
Cancer Stem Cell Hierarchy in Glioblastoma Multiforme
Open accessAbstract
Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within the tumor. CSCs possess the ability for perpetual self-renewal and proliferation, producing downstream progenitor cells that drive tumor growth. Studies of many cancer types have identified CSCs using specific markers, but it is still unclear as to where in the stem cell hierarchy these markers fall. This is compounded further by the presence of multiple GBM and glioblastoma cancer stem cell subtypes, making investigation and establishment of a universal treatment difficult. This review examines the current knowledge on the CSC markers SALL4, OCT-4, SOX2, STAT3, NANOG, c-Myc, KLF4, CD133, CD44, nestin, and glial fibrillary acidic protein, specifically focusing on their use and validity in GBM research and how they may be utilized for investigations into GBM's cancer biology.
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Brain Tumor Microenvironment and Host State: Implications for Immunotherapy
Tomaszewski, W., Sanchez-Perez, L., Gajewski, T. F., & Sampson, J. H. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1627 · Cited by 319
Glioblastoma Therapy: Past, Present and Future
Obrador, E., Moreno-Murciano, P., Oriol-Caballo, M., López-Blanch, R., Pineda, B., Gutiérrez-Arroyo, J., Loras, A., Gonzalez-Bonet, L., Martinez-Cadenas, C., Estrela, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052529 · Cited by 271
Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy
Yi, Y., Hsieh, I.-Y., Huang, X., Li, J., & Zhao, W. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00477 · Cited by 105
Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells
Her, N.-G., Oh, J.-W., Oh, Y. J., Han, S., Cho, H. J., Lee, Y., Ryu, G. H., & Nam, D.-H. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0825-1 · Cited by 68
Genetic Architectures and Cell-of-Origin in Glioblastoma
Kim, H. J., Park, J. W., & Lee, J. H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.615400 · Cited by 69
Metadata
- Authors
- Bradshaw, A., Wickremsekera, A., Tan, S. T., Peng, L., Davis, P. F., & Itinteang, T.
- Venue
- Frontiers in Surgery
- Publisher
- Frontiers Media SA
- Published
- 2016-04-15
- Volume
- 3
- Pages
- 21-21
- ISSN
- 2296-875X (ISSN-L)
- OpenAlex
- W2340024299
- Cited by
- 258
- References
- 225
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bradshaw, A., Wickremsekera, A., Tan, S. T., Peng, L., Davis, P. F., & Itinteang, T. (2016). Cancer Stem Cell Hierarchy in Glioblastoma Multiforme. Frontiers in Surgery. https://doi.org/10.3389/fsurg.2016.00021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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