The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Prevascularization of cardiac patch on the omentum improves its therapeutic outcome
Open accessAbstract
The recent progress made in the bioengineering of cardiac patches offers a new therapeutic modality for regenerating the myocardium after myocardial infarction (MI). We present here a strategy for the engineering of a cardiac patch with mature vasculature by heterotopic transplantation onto the omentum. The patch was constructed by seeding neonatal cardiac cells with a mixture of prosurvival and angiogenic factors into an alginate scaffold capable of factor binding and sustained release. After 48 h in culture, the patch was vascularized for 7 days on the omentum, then explanted and transplanted onto infarcted rat hearts, 7 days after MI induction. When evaluated 28 days later, the vascularized cardiac patch showed structural and electrical integration into host myocardium. Moreover, the vascularized patch induced thicker scars, prevented further dilatation of the chamber and ventricular dysfunction. Thus, our study provides evidence that grafting prevascularized cardiac patch into infarct can improve cardiac function after MI.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1327 · Cited by 2,206
Assmus, B., Schächinger, V., Teupe, C., Britten, M., Lehmann, R., Döbert, N., Grünwald, F., Aicher, A., Urbich, C., Martin, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000043246.74879.cd · Cited by 2,201
Engineering vascularized skeletal muscle tissue
Levenberg, S., Rouwkema, J., Macdonald, M., Garfein, E. S., Kohane, D. S., Darland, D. C., Marini, R., van Blitterswijk, C. A., Mulligan, R. C., D'Amore, P. A., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1109 · Cited by 1,293
Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction
Schächinger, V., Assmus, B., Britten, M. B., Honold, J., Lehmann, R., Teupe, C., Abolmaali, N. D., Vogl, T. J., Hofmann, W.-K., Martin, H., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.08.014 · Cited by 1,088
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Zimmermann, W.-H., Melnychenko, I., Wasmeier, G., Didié, M., Naito, H., Nixdorff, U., Hess, A., Budinsky, L., Brune, K., Michaelis, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1394 · Cited by 993
Tissue engineering of vascularized cardiac muscle from human embryonic stem cells
Caspi, O., Lesman, A., Basevitch, Y., Gepstein, A., Arbel, G., Habib, I. H. M., Gepstein, L., & Levenberg, S. (2007) · Circulation Research · doi:10.1161/01.res.0000257776.05673.ff · Cited by 558
Bioengineered Cardiac Grafts : A New Approach to Repair the Infarcted Myocardium?
Leor, J., Aboulafia-Etzion, S., Dar, A., Shapiro, L., Barbash, I. M., Battler, A., Granot, Y., & Cohen, S. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-56 · Cited by 558
Self-citationCardiomyocyte Cell Cycle Regulation
Pasumarthi, K. B. S., & Field, L. J. (2002) · Circulation Research · doi:10.1161/01.res.0000020201.44772.67 · Cited by 466
Zhang, M., Mal, N., Kiedrowski, M., Chacko, M., Askari, A. T., Popovic, Z. B., Koc, O. N., & Penn, M. S. (2007) · The FASEB Journal · doi:10.1096/fj.06-6558com · Cited by 457
Cited by
Nanotechnological strategies for engineering complex tissues
Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.246 · Cited by 1,367
Self-citationLaflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,206
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts
Noor, N., Shapira, A., Edri, R., Gal, I., Wertheim, L., & Dvir, T. (2019) · Advanced Science · doi:10.1002/advs.201900344 · Cited by 1,042
Self-citationNanowired three-dimensional cardiac patches
Dvir, T., Timko, B. P., Brigham, M. D., Naik, S. R., Karajanagi, S. S., Levy, O., Jin, H., Parker, K. K., Langer, R., & Kohane, D. S. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.160 · Cited by 760
Self-citationNavaei, A., Saini, H., Christenson, W., Sullivan, R. T., Ros, R., & Nikkhah, M. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.05.027 · Cited by 386
Metadata
- Authors
- Dvir, T., Kedem, A., Ruvinov, E., Levy, O., Freeman, I., Landa, N., Holbova, R., Feinberg, M. S., Dror, S., Etzion, Y., Leor, J., & Cohen, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-09
- Volume
- 106
- Issue
- 35
- Pages
- 14990-14995
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2029134257
- Cited by
- 345
- References
- 27
- FWCI
- 26.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Dvir, T., Kedem, A., Ruvinov, E., Levy, O., Freeman, I., Landa, N., Holbova, R., Feinberg, M. S., Dror, S., Etzion, Y., Leor, J., & Cohen, S. (2009). Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0812242106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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