The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Nanowired three-dimensional cardiac patches
Open accessAbstract
Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds. These biomaterials, which are usually made of either biological polymers such as alginate or synthetic polymers such as poly(lactic acid) (PLA), help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved in muscle contraction and electrical coupling are detected in the composite matrices. It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches.
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Cites
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Self-citationEngineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
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Self-citation
Cited by
Yuk, H., Lu, B., & Zhao, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00595h · Cited by 2,108
A flexible and highly sensitive strain-gauge sensor using reversible interlocking of nanofibres
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Metadata
- Authors
- Dvir, T., Timko, B. P., Brigham, M. D., Naik, S. R., Karajanagi, S. S., Levy, O., Jin, H., Parker, K. K., Langer, R., & Kohane, D. S.
- Venue
- Nature Nanotechnology
- Published
- 2011-09-25
- Volume
- 6
- Issue
- 11
- Pages
- 720-725
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2062164427
- Cited by
- 760
- References
- 31
- FWCI
- 38.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Dvir, T., Timko, B. P., Brigham, M. D., Naik, S. R., Karajanagi, S. S., Levy, O., Jin, H., Parker, K. K., Langer, R., & Kohane, D. S. (2011). Nanowired three-dimensional cardiac patches. Nature Nanotechnology. https://doi.org/10.1038/nnano.2011.160
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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