Cited by 108DNA Repair MechanismsCancer-related Molecular PathwaysCell death mechanisms and regulation

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DDB2 decides cell fate following DNA damage

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Stoyanova, Tanya, Roy, Nilotpal, Kopanja, Dragana, Bagchi, Srilata, Raychaudhuri, Pradip·2009·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0812254106PMC PMC2705559

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Abstract

The xeroderma pigmentosum complementation group E (XP-E) gene product damaged-DNA binding protein 2 (DDB2) plays important roles in nucleotide excision repair (NER). Previously, we showed that DDB2 participates in NER by regulating the level of p21(Waf1/Cip1). Here we show that the p21(Waf1/Cip1) -regulatory function of DDB2 plays a central role in defining the response (apoptosis or arrest) to DNA damage. The DDB2-deficient cells are resistant to apoptosis in response to a variety of DNA-damaging agents, despite activation of p53 and the pro-apoptotic genes. Instead, these cells undergo cell cycle arrest. Also, the DDB2-deficient cells are resistant to E2F1-induced apoptosis. The resistance to apoptosis of the DDB2-deficient cells is caused by an increased accumulation of p21(Waf1/Cip1) after DNA damage. We provide evidence that DDB2 targets p21(Waf1/Cip1) for proteolysis. The resistance to apoptosis in DDB2-deficient cells also involves Mdm2 in a manner that is distinct from the p53-regulatory activity of Mdm2. Our results provide evidence for a new regulatory loop involving the NER protein DDB2, Mdm2, and p21(Waf1/Cip1) that is critical in deciding cell fate (apoptosis or arrest) upon DNA damage.

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Additional file 6 of Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
Grandt, C. L., Brackmann, L. K., Alicia, P., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21018970
Additional file 9 of Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
Grandt, C. L., Brackmann, L. K., Alicia, P., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21018979
Additional file 2 of Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
Grandt, C. L., Brackmann, L. K., Alicia, P., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21018955
Additional file 10 of Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
Grandt, C. L., Brackmann, L. K., Alicia, P., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21018940
Additional file 4 of Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
Grandt, C. L., Brackmann, L. K., Alicia, P., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21018964
Additional file 11 of Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
Grandt, C. L., Brackmann, L. K., Alicia, P., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21018943

Authors: Stoyanova, T., Roy, N., Kopanja, D., Bagchi, S., & Raychaudhuri, P.
Affiliations: University of Illinois Chicago (US)
ORCID: Stoyanova, Tanya
Roy, Nilotpal
Kopanja, Dragana
Raychaudhuri, Pradip
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2009-06-30
Volume: 106
Issue: 26
Pages: 10690-10695
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0812254106
PMC: PMC2705559
OpenAlex: W2034903905
Cited by: 108
References: 40
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 18 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 12 · 2012: 7
FWCI: 3.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Illinois at Urbana-Champaign
National Institute on Aging (R01AG024138, AG024138)
National Cancer Institute (R01CA077637, CA77637)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: DDB2, nucleotide excision repair, p21, apoptosis, cell cycle arrest, MDM2, p53, E2F1, DNA damage response, proteolysis, cell fate determination
MeSH terms: Animals, Antineoplastic Agents, Cell Cycle, Cells, Cultured, Cisplatin, DNA Damage, DNA Repair, DNA-Binding Proteins, Fibroblasts, Flow Cytometry, HeLa Cells, Humans, Ultraviolet Rays, Blotting, Western, Aclarubicin, Tumor Suppressor Protein p53, Apoptosis, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, In Situ Nick-End Labeling, Cyclin-Dependent Kinase Inhibitor p21, Mice, Proto-Oncogene Proteins c-mdm2

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DDB2 decides cell fate following DNA damage

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