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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
Open accessAbstract
Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.
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Citations
Cited by
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Louie, A. (2010) · Chemical Reviews · doi:10.1021/cr9003538 · Cited by 1,044
Molecular imaging: current status and emerging strategies
Pysz, M. A., Gambhir, S. S., & Willmann, J. K. (2010) · Clinical Radiology · doi:10.1016/j.crad.2010.03.011 · Cited by 572
Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives
Hahn, M. A., Singh, A. K., Sharma, P., Brown, S. C., & Moudgil, B. M. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4207-5 · Cited by 485
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2018) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 426
Structural and functional photoacoustic molecular tomography aided by emerging contrast agents
Nie, L., & Chen, X. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00086b · Cited by 383
Metadata
- Authors
- Bouchard, L.-S., Anwar, M. S., Liu, G. L., Hann, B., Xie, Z. H., Gray, J. W., Wang, X., Pines, A., & Chen, F. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-03-17
- Volume
- 106
- Issue
- 11
- Pages
- 4085-4089
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016320594
- Cited by
- 183
- References
- 0
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bouchard, L.-S., Anwar, M. S., Liu, G. L., Hann, B., Xie, Z. H., Gray, J. W., Wang, X., Pines, A., & Chen, F. F. (2009). Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0813019106
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