The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Molecular imaging: current status and emerging strategies
Open accessAbstract
In vivo molecular imaging has a great potential to impact medicine by detecting diseases in early stages (screening), identifying extent of disease, selecting disease- and patient-specific therapeutic treatment (personalized medicine), applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current clinical molecular imaging approaches primarily use PET- or SPECT-based techniques. In ongoing preclinical research novel molecular targets of different diseases are identified and, sophisticated and multifunctional contrast agents for imaging these molecular targets are developed along with new technologies and instrumentation for multimodality molecular imaging. Contrast-enhanced molecular ultrasound with molecularly-targeted contrast microbubbles is explored as a clinically translatable molecular imaging strategy for screening, diagnosing, and monitoring diseases at the molecular level. Optical imaging with fluorescent molecular probes and ultrasound imaging with molecularly-targeted microbubbles are attractive strategies since they provide real-time imaging, are relatively inexpensive, produce images with high spatial resolution, and do not involve exposure to ionizing irradiation. Raman spectroscopy/microscopy has emerged as a molecular optical imaging strategy for ultrasensitive detection of multiple biomolecules/biochemicals with both in vivo and ex vivo versatility. Photoacoustic imaging is a hybrid of optical and ultrasound modalities involving optically-excitable molecularly-targeted contrast agents and quantitative detection of resulting oscillatory contrast agent movement with ultrasound. Current preclinical findings and advances in instrumentation such as endoscopes and microcatheters suggest that these molecular imaging modalities have numerous clinical applications and will be translated into clinical use in the near future.
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Precise nanomedicine for intelligent therapy of cancer
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Self-citation
Metadata
- Authors
- Pysz, M. A., Gambhir, S. S., & Willmann, J. K.
- Venue
- Clinical Radiology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 65
- Issue
- 7
- Pages
- 500-516
- ISSN
- 0009-9260 (ISSN-L)
- OpenAlex
- W2085375398
- Cited by
- 572
- References
- 130
- FWCI
- 22.21
- Type
- journal article
- Language
- en
- Open access
- green
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