The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
Open accessAbstract
The Suppressor of Fused [Su(fu)] protein plays a conserved role in the regulation of Gli transcription factors of the hedgehog (Hh) signaling pathway that controls cell fate and tissue patterning during development. In both Drosophila and mammals, Su(fu) represses Gli-mediated transcription, but the mode of its action is not completely understood. Recent evidence suggests that Su(fu) physically interacts with the Gli proteins and, when overexpressed, sequesters Gli in the cytoplasm. However, Su(fu) also traverses into the nucleus under the influence of a serine-threonine kinase, Fused (Fu), and has the ability to form a DNA-binding complex with Gli, suggesting that it has a nuclear function. Here we report that the mouse homolog of Su(fu) [mSu(fu)] specifically interacts with SAP18, a component of the mSin3 and histone deacetylase complex. In addition, we demonstrate that mSu(fu) functionally cooperates with SAP18 to repress transcription by recruiting the SAP18-mSin3 complex to promoters containing the Gli-binding element. These results provide biochemical evidence that Su(fu) directly participates in modulating the transcriptional activity of Gli.
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Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578
Cited by
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194
Svärd, J., Henricson, K. H., Persson-Lek, M., Rozell, B., Lauth, M., Bergström, Å., Ericson, J., Toftgård, R., & Teglund, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.013 · Cited by 468
Humke, E. W., Dorn, K. V., Milenkovic, L., Scott, M. P., & Rohatgi, R. (2010) · Genes & Development · doi:10.1101/gad.1902910 · Cited by 444
Canettieri, G., Di Marcotullio, L., Greco, A., Coni, S., Antonucci, L., Infante, P., Pietrosanti, L., De Smaele, E., Ferretti, E., Miele, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2013 · Cited by 322
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
Jia, J., Kolterud, Å., Zeng, H., Hoover, A., Teglund, S., Toftgård, R., & Liu, A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.04.009 · Cited by 132
Metadata
- Authors
- Cheng, S. Y., & Bishop, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-16
- Volume
- 99
- Issue
- 8
- Pages
- 5442-5447
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2118132057
- Cited by
- 221
- References
- 2
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheng, S. Y., & Bishop, J. M. (2002). Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.082096999
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