The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A ligand-binding pocket in the dengue virus envelope glycoprotein
Open accessAbstract
Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a β-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.
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[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
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Virus entry: molecular mechanisms and biomedical applications
Dimitrov, D. S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro817 · Cited by 701
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
Priyamvada, L., Quicke, K. M., Hudson, W. H., Onlamoon, N., Sewatanon, J., Edupuganti, S., Pattanapanyasat, K., Chokephaibulkit, K., Mulligan, M. J., Wilson, P. C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607931113 · Cited by 587
Dengue virus life cycle: viral and host factors modulating infectivity
Rodenhuis-Zybert, I. A., Wilschut, J., & Smit, J. M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0357-z · Cited by 499
Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells
van der Schaar, H. M., Rust, M. J., Chen, C., van der Ende-Metselaar, H., Wilschut, J., Zhuang, X., & Smit, J. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000244 · Cited by 490
Recognition determinants of broadly neutralizing human antibodies against dengue viruses
Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M.-C., Kikuti, C. M., Navarro Sanchez, M. E., Dejnirattisai, W., Wongwiwat, W., Haouz, A., et al. (2015) · Nature · doi:10.1038/nature14130 · Cited by 357
Metadata
- Authors
- Modis, Y., Ogata, S., Clements, D., & Harrison, S. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-05-20
- Volume
- 100
- Issue
- 12
- Pages
- 6986-6991
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137995709
- Cited by
- 1,061
- References
- 2
- FWCI
- 45.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Modis, Y., Ogata, S., Clements, D., & Harrison, S. C. (2003). A ligand-binding pocket in the dengue virus envelope glycoprotein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0832193100
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