Virus entry: molecular mechanisms and biomedical applications
Open accessAbstract
Viruses have evolved to enter cells from all three domains of life--Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines.
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- Authors
- Dimitrov, D. S.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- Corresponding author
- Dimitrov, Dimiter S.
- ORCID
- Dimitrov, Dimiter S.
- Venue
- Nature Reviews Microbiology
- Published
- 2004-02
- Volume
- 2
- Issue
- 2
- Pages
- 109-122
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC7097642
- OpenAlex
- W2025592853
- Cited by
- 701
- References
- 113
- Citations by year
- 2026: 43 · 2025: 46 · 2024: 96 · 2023: 72 · 2022: 48 · 2021: 74 · 2020: 26 · 2019: 9 · 2018: 21 · 2017: 20 · 2016: 14 · 2015: 18 · 2014: 18 · 2013: 17 · 2012: 18
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Keywords
- viral entry, host cell receptors, viral attachment, conformational change, animal viruses, host-virus interaction, antiviral agents, vaccine development
- MeSH terms
- Animals, Antibodies, Viral, Humans, Membrane Fusion, Protein Conformation, Receptors, Virus, Viral Vaccines, Viruses
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