Cited by 705Virology and Viral DiseasesVirus-based gene therapy researchBacteriophages and microbial interactions

Virus entry: molecular mechanisms and biomedical applications

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Dimitrov, Dimiter S.·2004·Nature Reviews Microbiology

Abstract

Viruses have evolved to enter cells from all three domains of life--Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines.

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Authors
Dimitrov, D. S.
Affiliations
Frederick National Laboratory for Cancer Research (US)
Corresponding author
Dimitrov, Dimiter S.
Venue
Nature Reviews Microbiology
Published
2004-02
Volume
2
Issue
2
Pages
109-122
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2025592853
Cited by
701
References
113
Citations by year
2026: 43 · 2025: 46 · 2024: 96 · 2023: 72 · 2022: 48 · 2021: 74 · 2020: 26 · 2019: 9 · 2018: 21 · 2017: 20 · 2016: 14 · 2015: 18 · 2014: 18 · 2013: 17 · 2012: 18
FWCI
3.80
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
Keywords
viral entry, host cell receptors, viral attachment, conformational change, animal viruses, host-virus interaction, antiviral agents, vaccine development
MeSH terms
Animals, Antibodies, Viral, Humans, Membrane Fusion, Protein Conformation, Receptors, Virus, Viral Vaccines, Viruses

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