The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
Open accessAbstract
Vitamin deficiency affects up to 50% of the world's population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic plants offer an effective way to increase the vitamin content of staple crops, but thus far it has only been possible to enhance individual vitamins. We created elite inbred South African transgenic corn plants in which the levels of 3 vitamins were increased specifically in the endosperm through the simultaneous modification of 3 separate metabolic pathways. The transgenic kernels contained 169-fold the normal amount of β-carotene, 6-fold the normal amount of ascorbate, and double the normal amount of folate. Levels of engineered vitamins remained stable at least through to the T3 homozygous generation. This achievement, which vastly exceeds any realized thus far by conventional breeding alone, opens the way for the development of nutritionally complete cereals to benefit the world's poorest people.
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Cites
Engineering the Provitamin A (β-Carotene) Biosynthetic Pathway into (Carotenoid-Free) Rice Endosperm
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Improving the nutritional value of Golden Rice through increased pro-vitamin A content
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Natural Genetic Variation in Lycopene Epsilon Cyclase Tapped for Maize Biofortification
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Increasing vitamin C content of plants through enhanced ascorbate recycling
Chen, Z., Young, T. E., Ling, J., Chang, S.-C., & Gallie, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0635176100 · Cited by 523
Gene stacking in transgenic plants – the challenge for 21st century plant biotechnology
Halpin, C. (2005) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2004.00113.x · Cited by 405
Particle bombardment and the genetic enhancement of crops: myths and realities
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Self-citationZhu, C., Naqvi, S., Breitenbach, J., Sandmann, G., Christou, P., & Capell, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809737105 · Cited by 359
Self-citationTransgenic strategies for the nutritional enhancement of plants
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Self-citationDrakakaki, G., Marcel, S., Glahn, R. P., Lund, E. K., Pariagh, S., Fischer, R., Christou, P., & Stoger, E. (2005) · Plant Molecular Biology · doi:10.1007/s11103-005-1537-3 · Cited by 275
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Cited by
Carotenoid Metabolism in Plants
Nisar, N., Li, L., Lu, S., Khin, N. C., & Pogson, B. J. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.007 · Cited by 1,255
In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning
Greco, M., Chiappetta, A., Bruno, L., & Bitonti, M. B. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err313 · Cited by 538
Metabolomics for Plant Improvement: Status and Prospects
Kumar, R., Bohra, A., Pandey, A. K., Pandey, M. K., & Kumar, A. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01302 · Cited by 328
Travel advice on the road to carotenoids in plants
Farré, G., Sanahuja, G., Naqvi, S., Bai, C., Capell, T., Zhu, C., & Christou, P. (2010) · Plant Science · doi:10.1016/j.plantsci.2010.03.009 · Cited by 176
Self-citationProvitamin A metabolism and functions in mammalian biology
von Lintig, J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034629 · Cited by 138
Metadata
- Authors
- Naqvi, S., Zhu, C., Farre, G., Ramessar, K., Bassie, L., Breitenbach, J., Perez Conesa, D., Ros, G., Sandmann, G., Capell, T., & Christou, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-05-12
- Volume
- 106
- Issue
- 19
- Pages
- 7762-7767
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005848936
- Cited by
- 526
- References
- 26
- FWCI
- 37.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Naqvi, S., Zhu, C., Farre, G., Ramessar, K., Bassie, L., Breitenbach, J., Perez Conesa, D., Ros, G., Sandmann, G., Capell, T., & Christou, P. (2009). Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0901412106
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