The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Natural Genetic Variation in Lycopene Epsilon Cyclase Tapped for Maize Biofortification
Open accessAbstract
Dietary vitamin A deficiency causes eye disease in 40 million children each year and places 140 to 250 million at risk for health disorders. Many children in sub-Saharan Africa subsist on maize-based diets. Maize displays considerable natural variation for carotenoid composition, including vitamin A precursors α-carotene, β-carotene, and β-cryptoxanthin. Through association analysis, linkage mapping, expression analysis, and mutagenesis, we show that variation at the lycopene epsilon cyclase ( lcyE ) locus alters flux down α-carotene versus β-carotene branches of the carotenoid pathway. Four natural lcyE polymorphisms explained 58% of the variation in these two branches and a threefold difference in provitamin A compounds. Selection of favorable lcyE alleles with inexpensive molecular markers will now enable developing-country breeders to more effectively produce maize grain with higher provitamin A levels.
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Self-citationThe biosynthesis and nutritional uses of carotenoids
Fraser, P. (2004) · Progress in Lipid Research · doi:10.1016/j.plipres.2003.10.002 · Cited by 1,375
Structure of linkage disequilibrium and phenotypic associations in the maize genome
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Self-citationMaize association population: a high‐resolution platform for quantitative trait locus dissection
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Self-citationVITAMIN SYNTHESIS IN PLANTS: Tocopherols and Carotenoids
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Present and future of quantitative trait locus analysis in plant breeding
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Cited by
White, P. J., & Broadley, M. R. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2008.02738.x · Cited by 2,178
The Genetic Architecture of Maize Flowering Time
Buckler, E. S., Holland, J. B., Bradbury, P. J., Acharya, C. B., Brown, P. J., Browne, C., Ersoz, E., Flint-Garcia, S., Garcia, A., Glaubitz, J. C., et al. (2009) · Science · doi:10.1126/science.1174276 · Cited by 1,457
Self-citationCarotenoid Metabolism in Plants
Nisar, N., Li, L., Lu, S., Khin, N. C., & Pogson, B. J. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.007 · Cited by 1,255
Association mapping: critical considerations shift from genotyping to experimental design
Myles, S., Peiffer, J., Brown, P. J., Ersoz, E. S., Zhang, Z., Costich, D. E., & Buckler, E. S. (2009) · The Plant Cell · doi:10.1105/tpc.109.068437 · Cited by 857
Self-citationCarotenoids and their cleavage products: Biosynthesis and functions
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Metadata
- Authors
- Harjes, C. E., Rocheford, T. R., Bai, L., Brutnell, T. P., Kandianis, C. B., Sowinski, S. G., Stapleton, A. E., Vallabhaneni, R., Williams, M., Wurtzel, E. T., Yan, J., & Buckler, E. S.
- Venue
- Science
- Published
- 2008-01-18
- Volume
- 319
- Issue
- 5861
- Pages
- 330-333
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2117055393
- Cited by
- 788
- References
- 27
- FWCI
- 28.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Harjes, C. E., Rocheford, T. R., Bai, L., Brutnell, T. P., Kandianis, C. B., Sowinski, S. G., Stapleton, A. E., Vallabhaneni, R., Williams, M., Wurtzel, E. T., Yan, J., & Buckler, E. S. (2008). Natural Genetic Variation in Lycopene Epsilon Cyclase Tapped for Maize Biofortification. Science. https://doi.org/10.1126/science.1150255
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