NPAS3 is a trachealess homolog critical for lung development and homeostasis

The development of Drosophila melanogaster

Ingham, P. W. (1994) · Trends in Genetics · doi:10.1016/0168-9525(90)90017-z · Cited by 3,158 · see citing works

A genome-wide search for asthma susceptibility loci in ethnically diverse populations

(1997) · Nature Genetics · doi:10.1038/ng0497-389 · Cited by 702 · see citing works

The mammalian basic helix–loop–helix/PAS family of transcriptional regulators

Kewley, R. J., Whitelaw, M. L., & Chapman‐Smith, A. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00211-5 · Cited by 590 · see citing works

Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats

Massaro, G. D. C., & Massaro, D. J. (1997) · Nature Medicine · doi:10.1038/nm0697-675 · Cited by 536 · see citing works

Genetic Control of Branching Morphogenesis

Metzger, R. J., & Krasnow, M. A. (1999) · Science · doi:10.1126/science.284.5420.1635 · Cited by 502 · see citing works

Morphogenesis

Hogan, B. L. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80562-0 · Cited by 494 · see citing works

Development of neuroendocrine lineages requires the bHLH–PAS transcription factor SIM1Preprint

Michaud, J. L., Rosenquist, T. A., May, N. R., & Fan, C. (1998) · Genes & Development · doi:10.1101/gad.12.20.3264 · Cited by 391 · see citing works

Tube or Not Tube

Affolter, M., Bellusci, S., Itoh, N., Shilo, B., Thiery, J. P., & Werb, Z. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00410-0 · Cited by 269 · see citing works

trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.Preprint

Wilk, R., Weizman, I., & Shilo, B. (1996) · Genes & Development · doi:10.1101/gad.10.1.93 · Cited by 264 · see citing works

Identification of Functional Domains of the Aryl Hydrocarbon Receptor Nuclear Translocator Protein (ARNT)

Reisz‐Porszasz, S., Probst, M. R., Fukunaga, B. N., & Hankinson, O. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6075 · Cited by 255 · see citing works

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors

Erbel-Sieler, C., Dudley, C., Zhou, Y., Wu, X., Estill, S. J., Han, T., Diaz-Arrastia, R., Brunskill, E. W., Potter, S. S., & McKnight, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405310101 · Cited by 178 · see citing works

Defective Pulmonary Development in the Absence of Heparin-Binding Vascular Endothelial Growth Factor Isoforms

Galambos, C., Ng, Y., Ali, A., Noguchi, A., Lovejoy, S., D'Amore, P. A., & deMello, D. E. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.2.4703 · Cited by 159 · see citing works

The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins.Preprint

Zelzer, E., Wappner, P., & Shilo, B. (1997) · Genes & Development · doi:10.1101/gad.11.16.2079 · Cited by 154 · see citing works

Role of the PAS Domain in Regulation of Dimerization and DNA Binding Specificity of the Dioxin Receptor

Pongratz, I., Antonsson, C., Whitelaw, M., & Poellinger, L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4079 · Cited by 130 · see citing works

Identification of FGF10 Targets in the Embryonic Lung Epithelium during Bud Morphogenesis

Lü, J., Izvolsky, K. I., Qian, J., & Cardoso, W. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410714200 · Cited by 88 · see citing works

Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice

Brunskill, E. W., Ehrman, L. A., Williams, M. T., Klanke, J., Hammer, D., Schaefer, T. L., Sah, R., Il, G. W. D., Potter, S. S., & Vorhees, C. V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04291.x · Cited by 84 · see citing works

Identification of Functional Domains of the Aryl Hydrocarbon Receptor Nuclear Translocator Protein (ARNT)

Reisz‐Porszasz, S., Probst, M. R., Fukunaga, B. N., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6075-6086.1994 · Cited by 83 · see citing works

Bombesin-like peptide mediates lung injury in a baboon model of bronchopulmonary dysplasia.

Sunday, M. E., Yoder, B. A., Cuttitta, F. F., Haley, K. J., & Emanuel, R. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2329 · Cited by 81 · see citing works

A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma

Blumenthal, M. N., Langefeld, C. D., Beaty, T. H., Bleecker, E. R., Ober, C., Lester, L. A., Lange, E. M., Barnes, K. C., Wolf, R. L., King, R. A., et al. (2004) · Human Genetics · doi:10.1007/s00439-003-1030-5 · Cited by 74 · see citing works

FGF-10 inducesSP-CandBmp4and regulates proximal-distal patterning in embryonic tracheal epithelium

Hyatt, B. A., Shangguan, X., & Shannon, J. M. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00033.2004 · Cited by 70 · see citing works

Sim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants

Goshu, E., Jin, H., Fasnacht, R., Sepenski, M., Michaud, J. L., & Fan, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4147-4157.2002 · Cited by 55 · see citing works

p63 Overexpression Induces the Expression of Sonic Hedgehog

Caserta, T. M., Kommagani, R., Yuan, Z., Robbins, D. J., Mercer, C. A., & Kadakia, M. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0149 · Cited by 51 · see citing works

What transgenic mice tell us about neurodegenerative disease

Gurney, M. E. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200003)22:3 · Cited by 38 · see citing works

Functional analysis of the human Sprouty2 gene promoter

Ding, W., Bellusci, S., Shi, W., & Warburton, D. (2003) · Gene · doi:10.1016/j.gene.2003.09.004 · Cited by 34 · see citing works

Branching morphogenesis in the Drosophila tracheal system.

Shilo, B., Gabay, L., Glazer, L., Reichman‐Fried, M., Wappner, P., Wilk, R., & Zelzer, E. (1997) · PubMed · Cited by 30 · see citing works

HoxB-5 down regulation alters Tenascin-C, FGF10 AND HoxB gene expression patterns in pseudoglandular period fetal mouse lung

MaryAnn, V. V. (2006) · Frontiers in bioscience · doi:10.2741/2108 · Cited by 21 · see citing works

NPAS1 Regulates Branching Morphogenesis in Embryonic Lung

Levesque, B. M., Zhou, S., Shan, L., Johnston, P., Kong, Y., Degan, S., & Sunday, M. E. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0314oc · Cited by 16 · see citing works

Stimulation of phosphatidylcholine biosynthesis in mouse MLE-12 type-II cells by conditioned medium from cortisol-treated rat fetal lung fibroblasts

MacDonald, J. I. S., & Possmayer, F. (1995) · Biochemical Journal · doi:10.1042/bj3120425 · Cited by 11 · see citing works

Branch‐specific migration cues in the Drosophila tracheal system

Rosin, D., & Shilo, B. (2002) · BioEssays · doi:10.1002/bies.10041 · Cited by 6 · see citing works

[Respiratory allergic disease genes].

Demoly, P. M. (2003) · PubMed · Cited by 6 · see citing works

Lung development: orchestrating the generation and regeneration of a complex organ

Herriges, M., & Morrisey, E. E. (2014) · Development · doi:10.1242/dev.098186 · Cited by 613 · see citing works

Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila

Perochon, J., Yu, Y., Aughey, G., Medina, A. B., Southall, T. D., & Cordero, J. B. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00676-z · Cited by 58 · see citing works

Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations

Ding, L., Abebe, T., Beyene, J., Wilke, R. A., Goldberg, A., Woo, J. G., Martin, L. J., Rothenberg, M. E., Rao, M. B., Hershey, G. K. K., et al. (2013) · Human Genomics · doi:10.1186/1479-7364-7-16 · Cited by 58 · see citing works

Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis

Chung, S., Chavez, C., & Andrew, D. J. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.09.014 · Cited by 54 · see citing works

Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma

Yücesoy, B., Kaufman, K. M., Lummus, Z. L., Weirauch, M. T., Zhang, G., Cartier, A., Boulet, L., Sastre, J., Quirce, S., Tarlo, S. M., et al. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv084 · Cited by 54 · see citing works

Embryonic multipotent progenitors remodel theDrosophilaairways during metamorphosis

Pitsouli, C., & Perrimon, N. (2010) · Development · doi:10.1242/dev.056408 · Cited by 49 · see citing works

Neuronal PAS domain proteins 1 and 3 are master regulators of neuropsychiatric risk genes

Michaelson, J. J., Shin, M.-K., Koh, J.-Y., Brueggeman, L., Zhang, A., Katzman, A., McDaniel, L., Fang, M., Pufall, M., & Pieper, A. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.021 · Cited by 47 · see citing works

Association of NPAS3 exonic variation with schizophrenia

MacIntyre, G., Alford, T., Xiong, L., Rouleau, G. A., Tibbo, P. G., & Cox, D. W. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.04.002 · Cited by 46 · see citing works

Mechanisms of Na+ uptake from freshwater habitats in animals

Lee, C. E., Charmantier, G., & Lorin‐Nebel, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1006113 · Cited by 43 · see citing works

Choreoathetosis, congenital hypothyroidism and neonatal respiratory distress syndrome with intact NKX2‐1

Barnett, C., Mencel, J. J., Gécz, J., Waters, W., Kirwin, S. M., Vinette, K. M. B., Uppill, M., & Nicholl, J. K. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35456 · Cited by 42 · see citing works

Inhibition of miR-122 reduced atherosclerotic lesion formation by regulating NPAS3-mediated endothelial to mesenchymal transition

Wu, X., Du, X., Yang, Y., Liu, X., Liu, X., Zhang, N., Li, Y., Jiang, X., Jiang, Y., & Yang, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118816 · Cited by 39 · see citing works

Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder

Frints, S. G. M., Ozantürk, A., Criado, G. R., Grasshoff, U., de Hoon, B., Field, M. J., Manouvrier‐Hanu, S., Hickey, S. E., Kammoun, M., Gripp, K. W., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0065-x · Cited by 32 · see citing works

NPAS3 Demonstrates Features of a Tumor Suppressive Role in Driving the Progression of Astrocytomas

Moreira, F., Kiehl, T., So, K., Ajeawung, N. F., Honculada, C., Gould, P. V., Pieper, R. O., & Kamnasaran, D. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.044 · Cited by 31 · see citing works

Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors

Li, Y., Fan, T., Li, X., Liu, L., Mao, F., Li, Y., Miao, Z., Zeng, C., Song, W., Pan, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111289 · Cited by 25 · see citing works

Immunohistochemical Analyses of NPAS3 Expression in the Developing Human Fetal Brain: NPAS3 Expression in Human Fetal Brain

Gould, P., & Kamnasaran, D. (2011) · Anatomia, Histologia, Embryologia · doi:10.1111/j.1439-0264.2010.01059.x · Cited by 22 · see citing works

Molecular analysis of NPAS3 functional domains and variants

Luoma, L. M., & Berry, F. B. (2018) · BMC Molecular Biology · doi:10.1186/s12867-018-0117-4 · Cited by 19 · see citing works

Comparative molecular developmental aspects of the mammalian- and the avian lungs, and the insectan tracheal system by branching morphogenesis: recent advances and future directions

Maina, J. N. (2012) · Frontiers in Zoology · doi:10.1186/1742-9994-9-16 · Cited by 18 · see citing works

Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates

Li, K.-L., Lu, T.-M., & Yu, J. (2014) · EvoDevo · doi:10.1186/2041-9139-5-20 · Cited by 16 · see citing works

Parametric Linkage Analysis Identifies Five Novel Genome-Wide Significant Loci for Familial Lung Cancer

Musolf, A. M., Simpson, C. L., de Andrade, M., Mandal, D. M., Gaba, C., Yang, P., Li, Y., You, M., Kupert, E. Y., Anderson, M. W., et al. (2016) · Human Heredity · doi:10.1159/000479028 · Cited by 15 · see citing works

Conserved and Unique Roles of bHLH-PAS Transcription Factors in Insects – From Clock to Hormone Reception

Tumova, S., Doležel, D., & Jindra, M. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168332 · Cited by 14 · see citing works

Novel alternative splice variants of chicken NPAS3 are expressed in the developing central nervous system

Shin, J., & Kim, J. (2013) · Gene · doi:10.1016/j.gene.2013.08.024 · Cited by 12 · see citing works

Glial response to hypoxia in mutants of NPAS1/3 homolog Trachealess through Wg signaling to modulate synaptic bouton organization

Chen, P., Tsai, Y.-W., Cheng, Y.-J., Giangrande, A., & Chien, C. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007980 · Cited by 8 · see citing works

The Human Accelerated Region HAR202 Controls <i>NPAS3</i> Expression in the Developing Forebrain Displaying Differential Enhancer Activity Between Modern and Archaic Human Sequences

Caporale, A. L., Cinalli, A. R., Rubinstein, M., & Franchini, L. F. (2024) · Molecular Biology and Evolution · doi:10.1093/molbev/msae186 · Cited by 7 · see citing works

Population genomics of sika deer reveals recent speciation and genetic selective signatures during evolution and domestication

Liu, H., Zhu, B., Wang, T., Dong, Y., Ju, Y., Li, Y., Su, W., Zhang, R., Dong, S., Wang, H., et al. (2025) · BMC Genomics · doi:10.1186/s12864-025-11541-w · Cited by 6 · see citing works

Lower NPAS3 expression during the later stages of abnormal lung development in rat congenital diaphragmatic hernia

Pereira‐Terra, P., Kholdebarin, R., Higgins, M., Iwasiow, B. M., Correia‐Pinto, J., & Keijzer, R. (2015) · Pediatric Surgery International · doi:10.1007/s00383-015-3703-2 · Cited by 5 · see citing works

Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT

Li, P., Tian, Y., Shang, Q., Tang, C., Zeng, H. L., Li, Y., Cao, L., Xue, S., Bian, J., Luo, C., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106676 · Cited by 4 · see citing works

Physiology of Ventilation

Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_4 · Cited by 2 · see citing works

An evo-devo perspective on terrestrial isopod respiratory organs

Tan, K. L., & Monteiro, A. (2025) · Arthropod Structure & Development · doi:10.1016/j.asd.2025.101470 · Cited by 2 · see citing works

Cardiovascular Physiology

Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_3 · Cited by 2 · see citing works

Anatomy of the Ventilatory Apparatus

Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_2 · Cited by 1 · see citing works

Study of developmental genes in opisthosomal limb development in the spider Parasteatoda tepidariorum

Gaspar, M. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Anatomy of the Cardiovascular Apparatus

Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_1

Medical Images and Physiological Signals

Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_5

Expression and function of Npas4 during early development.

Klarić, T. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

Différenciation des cellules souches embryonnaires humaines en cellules épithéliales respiratoires.

Navarre, A. (2016) · doi:10.70675/cb95c371zdf96z4569za402za35116916f8a

Etude fonctionnelle de mutations du gène codant NKX2-1 associées à une atteinte respiratoire de l’enfant

Nattes, E. (2019) · doi:10.70675/4cf35d9bzce5fz41b8za235zd5ddadff791d

NPAS3 promotes lung development by up‐regulating FGF signaling

Sunday, M. E., Zhou, S., Degan, S., Potts, E. N., & Foster, W. M. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.572.1

Respiratory lethality in newborn NPAS3‐deficient mice

Zhou, S., Degan, S., & Sunday, M. E. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.47.1

REGULATION OF MURINE EMBRYONIC LUNG DEVELOPMENT BY NPAS1 AND NPAS3

Zhou, S., Shan, L., & Sunday, M. E. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a208

NPAS1 Regulates Branching Morphogenesis in Embryonic Lung

Levesque, B. M., Zhou, S., Shan, L., Johnston, P., Kong, Y., Degan, S., & Sunday, M. E. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0314oc · Cited by 16 · see citing works

Abnormal Heart Development and Lung Remodeling in Mice Lacking the Hypoxia-Inducible Factor-Related Basic Helix-Loop-Helix PAS Protein NEPAS

Yamashita, T., Ohneda, O., Nagano, M., Iemitsu, M., Makino, Y., Tanaka, H., Miyauchi, T., Goto, K., Ohneda, K., Fujii‐Kuriyama, Y., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01332-07 · Cited by 115 · see citing works