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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
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We recently showed that the mammalian genome encodes >1,000 large intergenic noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene expression patterns have implicated these lincRNAs in diverse biological processes, including cell-cycle regulation, immune surveillance, and embryonic stem cell pluripotency. However, the mechanism by which these lincRNAs function is unknown. Here, we expand the catalog of human lincRNAs to ≈3,300 by analyzing chromatin-state maps of various human cell types. Inspired by the observation that the well-characterized lincRNA HOTAIR binds the polycomb repressive complex (PRC)2, we tested whether many lincRNAs are physically associated with PRC2. Remarkably, we observe that ≈20% of lincRNAs expressed in various cell types are bound by PRC2, and that additional lincRNAs are bound by other chromatin-modifying complexes. Also, we show that siRNA-mediated depletion of certain lincRNAs associated with PRC2 leads to changes in gene expression, and that the up-regulated genes are enriched for those normally silenced by PRC2. We propose a model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression.
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“Several noncoding RNAs were reported to mediate p53-dependent gene regulation—these include microRNAs120 and long noncoding RNAs,121 such as TUG1,122, 123 miR-34,124 lincRNA-p21,125 PANDA126 and PINT.127”
From Census and evaluation of p53 target genes (2017) · cites this paper as [122]
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Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Self-citationHigh-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246
Self-citationGenome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Self-citationChromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Self-citationPolycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome
Zhao, J. C., Sun, B. K., Erwin, J. A., Song, J., & Lee, J. T. (2008) · Science · doi:10.1126/science.1163045 · Cited by 1,580
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsPreprint
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,286
Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., Komorowski, J., Nagano, T., Mancini‐DiNardo, D., & Kanduri, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.022 · Cited by 1,192
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
Ku, M., Koche, R. P., Rheinbay, E., Mendenhall, E. M., Endoh, M., Mikkelsen, T. S., Aiden, A. P., Nusbaum, C., Xie, X. S., Chi, A. S., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000242 · Cited by 1,053
Self-citation
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Items 701–800 of 1,004
Szafrański, P., Dharmadhikari, A. V., Wambach, J., Towe, C. T., White, F. V., Grady, R. M., Eghtesady, P., Cole, F. S., Deutsch, G. H., Sen, P., et al. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36606 · Cited by 98
Expression Profiling Reveals Developmentally Regulated lncRNA Repertoire in the Mouse Male Germline1
Bao, J., Wu, J., Schuster, A. S., Hennig, G. W., & Yan, W. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.113308 · Cited by 101
Pearson, M. J., & Jones, S. W. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39759 · Cited by 98
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
Wei, C.-W., Luo, T., Zou, S.-S., & Wu, A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00175 · Cited by 104
Özgür, E., Mert, U., Işın, M., Okutan, M., Dalay, N., & Deligezer, U. (2012) · Clinical and Experimental Medicine · doi:10.1007/s10238-012-0181-x · Cited by 97
Characterization of Enhancer Function from Genome-Wide Analyses
Maston, G. A., Landt, S. G., Snyder, M. P., & Green, M. R. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163723 · Cited by 105
The roles of non-coding RNAs in Parkinson’s disease
Majidinia, M., Mihanfar, A., Rahbarghazi, R., Nourazarian, A., Bağca, B. G., & Avcı, Ç. B. (2016) · Molecular Biology Reports · doi:10.1007/s11033-016-4054-3 · Cited by 96
Ma, H., Xie, M., Sun, M., Chen, T., Jin, R.-R., Ma, T., Chen, Q., Zhang, E., He, X., De, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11075 · Cited by 97
She, K., Huang, J., Zhou, H., Huang, T., Chen, G., & He, J. (2016) · Oncology Reports · doi:10.3892/or.2016.5105 · Cited by 97
Research progresses in roles of LncRNA and its relationships with breast cancer
Xu, B., Hongjian, Y., Zhang, X., Bo, C., Shifeng, Y., & Tang, B. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0674-0 · Cited by 97
Zou, Y., Jiang, Z., Yu, X., Sun, M., Zhang, Y., Zuo, Q., Zhou, J., Yang, N., Han, P., Ge, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079598 · Cited by 97
Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs
Signal, B., Gloss, B., & Dinger, M. E. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.08.004 · Cited by 97
Evolutionary conservation and functional roles of ncRNA
Qu, Z., & Adelson, D. L. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00205 · Cited by 100
Long non-coding RNAs and chromatin regulation
Lucia, F. D., & Dean, C. (2010) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2010.11.006 · Cited by 96
Yuan, J., Zhang, Y., Dong, J., Sun, Y., Lim, B. L., Liu, D., & Lu, Z. J. (2016) · BMC Genomics · doi:10.1186/s12864-016-2929-2 · Cited by 93
Epigenetic Control of the Genome—Lessons from Genomic Imprinting
Aðalsteinsson, B. Þ., & Ferguson‐Smith, A. C. (2014) · Genes · doi:10.3390/genes5030635 · Cited by 101
Lv, M., Xu, P., Wu, Y., Huang, L., Li, W., Lv, S., Wu, X., Zeng, X., Shen, R., Jia, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7509 · Cited by 97
Kadakkuzha, B. M., Liu, X.-A., McCrate, J., Shankar, G., Rizzo, V., Afinogenova, A., Young, B. M., Fallahi, M., Carvalloza, A. C., Raveendra, B., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00063 · Cited by 96
Kobow, K., & Blümcke, I. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.01.012 · Cited by 100
Transcriptional gene silencing in humans
Weinberg, M. S., & Morris, K. V. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw139 · Cited by 95
Liu, Q., Liu, H., Cheng, H., Li, Y., Li, X., & Zhu, C. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s124595 · Cited by 94
RetractedRegulation of the ESC transcriptome by nuclear long noncoding RNAsPreprint
Bergmann, J. H., Li, J., Eckersley-Maslin, M. A., Rigo, F., Freier, S. M., & Spector, D. L. (2015) · Genome Research · doi:10.1101/gr.189027.114 · Cited by 93
Tan, H., Zhang, S., Zhang, J., Zhu, L., Chen, Y., Yang, H., Chen, Y., An, Y., & Liu, B. (2020) · Theranostics · doi:10.7150/thno.47548 · Cited by 95
Lauretti, E., Dabrowski, K. R., & Praticò, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101425 · Cited by 97
Amin, V. R., Harris, R. A., Onuchic, V., Jackson, A. R., Charnecki, T., Paithankar, S., Subramanian, S. L., Riehle, K. P., Coarfa, C., & Milosavljevic, A. (2015) · Nature Communications · doi:10.1038/ncomms7370 · Cited by 93
Shvedova, A. A., Yanamala, N. V. K., Kisin, E. R., Оскарович, Х. Т., Birch, M. E., & Fatkhutdinova, L. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150628 · Cited by 92
Long non-coding RNAs in osteosarcoma
Chen, R., Wang, G., Zheng, Y., Hua, Y., & Cai, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.14726 · Cited by 93
Long noncoding RNA HAS2‐AS1 mediates hypoxia‐induced invasiveness of oral squamous cell carcinoma
Zhu, G., Wang, S., Chen, J., Wang, Z., Liang, X., Wang, X., Jiang, J., Lang, J., & Li, L. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22674 · Cited by 92
The long noncoding RNA ROCKI regulates inflammatory gene expression
Zhang, Q., Chao, T., Patil, V. S., Qin, Y., Tiwari, S. K., Chiou, J., Dobin, A., Tsai, C., Li, Z., Dang, J. W., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100041 · Cited by 92
Exosomal Non-Coding RNAs: Diagnostic, Prognostic and Therapeutic Applications in Cancer
Bullock, M. D., da Silva, A. M., Kanlikilicer, P., Filant, J., Rashed, M. H., Sood, A. K., Lopez‐Berestein, G., & Călin, G. A. (2015) · Non-Coding RNA · doi:10.3390/ncrna1010053 · Cited by 92
microRNAs and ceRNAs: RNA networks in pathogenesis of cancer.
Su, X., Xing, J., Wang, Z., Chen, L., Cui, M., & Jiang, B. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.1000-9604.2013.03.08 · Cited by 93
The decline and fall of the IGF‐I receptor
Baserga, R. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24217 · Cited by 91
Epigenetics in cardiovascular disease
Shirodkar, A., & Marsden, P. A. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328345986e · Cited by 92
An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk
Zhu, Z., Gao, X., He, Y., Zhao, H., Yu, Q., Jiang, D., Zhang, P., Ma, X., Huang, H., Dong, D., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0010 · Cited by 91
Zang, W., Wang, T., Wang, Y., Chen, X., Du, Y., Sun, Q., Li, M., Dong, Z., & Zhao, G. (2016) · Oncotarget · doi:10.18632/oncotarget.6963 · Cited by 91
Xie, C., Wang, F., Zhang, S., Wang, F., Zheng, S., Zhao, L., Lv, J., Qi, H.-Q., Fang, Q., Wang, X., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.10.018 · Cited by 91
Cross Talks between Oxidative Stress, Inflammation and Epigenetics in Diabetic Retinopathy
Kowluru, R. A. (2023) · Cells · doi:10.3390/cells12020300 · Cited by 100
Guo, J. K., Blanco, M. R., Walkup, W. G., Bonesteele, G., Urbinati, C. R., Banerjee, A. K., Chow, A. Y., Ettlin, O., Strehle, M. M., Peyda, P., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.01.026 · Cited by 91
Self-citationSystematic classification of non-coding RNAs by epigenomic similarity
Dozmorov, M. G., Giles, C. B., Koelsch, K. A., & Wren, J. D. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-s14-s2 · Cited by 94
Liu, Q., Sun, S., Yu, W., Jiang, J., Zhuo, F., Qiu, G., Xu, S., & Jiang, X. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1718-0 · Cited by 90
Zhou, Z., Li, A., Adeola, A. C., Yan-hu, L., Irwin, D. M., Xie, H., & Zhang, Y. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu113 · Cited by 91
X Chromosome Inactivation and Epigenetic Responses to Cellular Reprogramming
Lessing, D., & Lee, J. T. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091212-153530 · Cited by 93
Pyicos: a versatile toolkit for the analysis of high-throughput sequencing data
Althammer, S., González‐Vallinas, J., Ballaré, C., Beato, M., & Eyras, E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr570 · Cited by 90
Wang, C., Liu, T., Zhang, X., Yang, Y., & Du, L. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s98268 · Cited by 90
Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver
Bian, E., Wang, Y., Yang, Y., Wu, B., Xu, T., Meng, X., Huang, C. Z., Zhang, L., Lv, X., Xiong, Z., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.12.009 · Cited by 91
LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer
Dan, J., Wang, J., Wang, Y., Zhu, M., Yang, X., Peng, Z., Jiang, H., & Chen, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.164 · Cited by 90
Zhang, X., Niu, W., Mu, M., Hu, S., & Niu, C. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01695-8 · Cited by 90
Epigenetics of the vascular endothelium
Yan, M. S.-C., Matouk, C. C., & Marsden, P. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00131.2010 · Cited by 100
MicroRNAs as Post-Transcriptional Machines and their Interplay with Cellular Networks
Janga, S. C., & Vallabhaneni, S. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0332-6_4 · Cited by 91
Long Noncoding RNAs in Diabetes and Diabetic Complications
Leung, A., & Natarajan, R. D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7315 · Cited by 90
Role of lncRNAs in aging and age‐related diseases
He, J., Tu, C., & Liu, Y. (2018) · Aging Medicine · doi:10.1002/agm2.12030 · Cited by 88
Işın, M., & Dalay, N. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.02.046 · Cited by 91
Negishi, M., Wongpalee, S. P., Sarkar, S., Park, J.-H., Lee, K. Y., Shibata, Y., Reon, B. J., Abounader, R., Suzuki, Y., Sugano, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095216 · Cited by 89
Long noncoding RNAs in the p53 network
Chaudhary, R., & Lal, A. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1410 · Cited by 88
Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance
Yan, W. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.008 · Cited by 92
Peng, H., Zou, L., Xie, J., Wu, H., Wu, B., Zhu, G., Lv, Q., Zhang, X., Liu, S., Li, G., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9632-1 · Cited by 88
Li, D., Fei, X.-R., Dong, Y., Cheng, C., Yang, Y., Deng, X., Huang, H.-L., Niu, W., Zhou, C.-X., Xia, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21513 · Cited by 90
The State of Long Non-Coding RNA Biology
Mattick, J. S. (2018) · Non-Coding RNA · doi:10.3390/ncrna4030017 · Cited by 95
Ashrafizadeh, M., Mohan, C. D., Rangappa, S., Zarrabi, A., Hushmandi, K., Kumar, A. P., Sethi, G., & Rangappa, K. S. (2023) · Medicinal Research Reviews · doi:10.1002/med.21950 · Cited by 89
Karlsson, O., Rodosthenous, R. S., Jara, C., Brennan, K. J. M., Wright, R. O., Baccarelli, A., & Wright, R. J. (2016) · Epigenetics · doi:10.1080/15592294.2016.1216285 · Cited by 88
Zhang, Y., Xu, Y., Sun, N., Liu, J., Chen, F.-F., Guan, X.-L., Li, A., Wang, F., Zhao, Q., Wang, H., et al. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1129-4 · Cited by 87
Tehrani, S. S., Karimian, A., Parsian, H., Majidinia, M., & Yousefi, B. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26217 · Cited by 85
The Role of Long Non-Coding RNAs in Hepatocarcinogenesis
Lanzafame, M., Bianco, G., Terracciano, L., Ng, C. K. Y., & Piscuoglio, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030682 · Cited by 87
Ren, Y., Wang, Y., Zhang, J., Wang, Q., Han, L., Mei, M., & Kang, C. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0624-2 · Cited by 87
Dai, Q., Zhang, T., Pan, J., & Li, C. (2020) · Journal of Cancer · doi:10.7150/jca.43446 · Cited by 87
Transcriptional adaptation: a mechanism underlying genetic robustness
Sztal, T. E., & Stainier, D. Y. R. (2020) · Development · doi:10.1242/dev.186452 · Cited by 87
Hao, Z., Fan, C., Cheng, T., Su, Y., Wei, Q., & Li, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121800 · Cited by 87
Discovery of Protein–lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets
Li, J., Liu, S., Zheng, L., Wu, J., Sun, W., Wang, Z., Zhou, H., Qu, L., & Yang, J. (2015) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00088 · Cited by 91
Transcription Factor Effector Domains
Frietze, S. E., & Farnham, P. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-9069-0_12 · Cited by 93
Wang, C., Wu, Q., Li, S., Chen, F., Tuo, L., Xie, H., Tong, Y., Ji, L., Zhou, G., Cao, G., et al. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2956-7 · Cited by 86
Palos, K. R., Yu, L., Railey, C. E., Dittrich, A. C. N., & Nelson, A. D. L. (2023) · The Plant Cell · doi:10.1093/plcell/koad027 · Cited by 85
Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis
Kiang, K. M. Y., Zhang, X., & Leung, G. (2015) · Cancers · doi:10.3390/cancers7030843 · Cited by 85
LncRNA NEAT1 enhances the radio-resistance of cervical cancer via miR-193b-3p/CCND1 axis
Han, D., Wang, J., & Cheng, G. (2017) · Oncotarget · doi:10.18632/oncotarget.23416 · Cited by 85
RetractedThe gut microbiota mediates protective immunity against tuberculosis via modulation of lncRNA
Yang, F., Yang, Y., Chen, L., Zhang, Z., Liu, L., Zhang, C., Mai, Q., Chen, Z., Chen, Z., Lin, T., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2029997 · Cited by 84
Epigenetic layers and players underlying neurodevelopment
LaSalle, J. M., Powell, W. T., & Yasui, D. H. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.001 · Cited by 89
Non-coding RNA and antisense RNA. Nature’s trash or treasure?
Knowling, S., & Morris, K. V. (2011) · Biochimie · doi:10.1016/j.biochi.2011.07.031 · Cited by 85
Circadian changes in long noncoding RNAs in the pineal gland
Coon, S. L., Munson, P. J., Cherukuri, P. F., Sugden, D., Rath, M. F., Møller, M., Clokie, S. J. H., Fu, C., Olanich, M. E., Rangel, Z. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207748109 · Cited by 86
Strategies to identify long noncoding RNAs involved in gene regulation
Lee, C. A. A., & Kikyo, N. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-37 · Cited by 86
Non-coding landscapes of colorectal cancer
Ragusa, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11709 · Cited by 86
Zhang, M., Gao, C., Yang, Y., Li, G., Dong, J., Ai, Y., Chen, N., & Li, W. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x14944585873668 · Cited by 85
Novel therapeutic targets for pancreatic cancer
Tang, S.-C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i31.10825 · Cited by 85
Noncoding RNAs in gene regulation
Wéry, M., Kwapisz, M., & Morillon, A. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.148 · Cited by 87
Parkinson, J., Wasmuth, J. D., Salinas, G., Bizarro, C. V., Sanford, C., Berriman, M., Ferreira, H. B., Zaha, A., Blaxter, M., Maizels, R. M., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001897 · Cited by 84
Long non-coding RNA: A newly deciphered “code” in prostate cancer
Zhang, A., Zhang, J., Kaipainen, A., Lucas, J. M., & Yang, H. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.003 · Cited by 84
Sun, W., Lan, X., Zhang, H., Wang, Z., Dong, W., He, L., Zhang, T., Zhang, P., Liu, J., & Qin, Y. H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0418-z · Cited by 84
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Thapar, R. (2018) · Molecules · doi:10.3390/molecules23112789 · Cited by 86
The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammalsPreprint
Duffié, R., Ajjan, S., Greenberg, M., Zamudio, N., Escamilla-Del-Arenal, M., Iranzo, J., Okamoto, I., Barbaux, S., Fauque, P., & Bourc’his, D. (2014) · Genes & Development · doi:10.1101/gad.232058.113 · Cited by 89
Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene ExpressionPreprint
McDonel, P. E., & Guttman, M. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032151 · Cited by 86
Self-citationNoncoding RNAs and enhancers: complications of a long-distance relationship
Ørom, U. A., & Shiekhattar, R. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.06.009 · Cited by 84
Li, J., Wang, Y., Yu, J., Dong, R., & Qiu, H. (2014) · Tumor Biology · doi:10.1007/s13277-014-2765-4 · Cited by 83
Potential roles of microRNAs in regulating long intergenic noncoding RNAs
Juan, L., Wang, G., Radovich, M., Schneider, B. P., Clare, S. E., Wang, Y., & Liu, Y. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-s1-s7 · Cited by 84
Genomic Insight into the Role of lncRNAs in Cancer Susceptibility
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Wang, D., Li, Q., Shen, W., Guo, H., & Zhao, S. (2017) · PubMed Central · Cited by 83
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Sinicropi, D. V., Qu, K., Collin, F., Crager, M., Liu, M., Pelham, R. J., Pho, M., Rossi, A. D., Jeong, J., Scott, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040092 · Cited by 82
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Huo, Y., Li, Q., Wang, X., Jiao, X., Zheng, J., Li, Z., & Pan, X. (2017) · Oncotarget · doi:10.18632/oncotarget.16551 · Cited by 82
RetractedLi, Y., Li, S.-H., Liu, Y., & Luo, Y.-T. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480532 · Cited by 82
Metadata
- Authors
- Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., Regev, A., Lander, E. S., & Rinn, J. L.
- Affiliations
- Broad Institute (US)
- Massachusetts Institute of Technology (US)
- The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
- Physics, Massachusetts Institute of Technology, Cambridge, MA 02139;
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-07-14
- Volume
- 106
- Issue
- 28
- Pages
- 11667-11672
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2704857
- OpenAlex
- W2144137532
- Cited by
- 2,872
- References
- 30
- Citations by year
- 2026: 35 · 2025: 54 · 2024: 81 · 2023: 96 · 2022: 115 · 2021: 164 · 2020: 206 · 2019: 208 · 2018: 216 · 2017: 230 · 2016: 235 · 2015: 269 · 2014: 248 · 2013: 243 · 2012: 197
- FWCI
- 52.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- National Institutes of Health (DP1OD003958)
- National Heart, Lung, and Blood Institute (T32HL007893, HL007893)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- long intergenic non-coding RNA, polycomb repressive complex 2, chromatin-modifying complexes, gene expression regulation, HOTAIR, chromatin state, siRNA knockdown, gene silencing, mammalian genomes
- MeSH terms
- Chromatin, Gene Expression Regulation, Humans, Models, Genetic, Repressor Proteins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, RNA, Untranslated, Epigenesis, Genetic, Polycomb-Group Proteins
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