The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
Open accessAbstract
Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan. RPE normally produces the more soluble isoforms, VEGF120 and VEGF164, but virtually no VEGF188, reflecting the fact that molecules secreted by the RPE must diffuse across Bruch's membrane (BrM) to reach the choriocapillaris. To determine the role of RPE-derived soluble VEGF on the choriocapillaris survival, we used mice that produce only VEGF188. VEGF188/188 mice exhibited normal choriocapillaris development. However, beginning at 7 months of age, we observed a progressive degeneration characterized by choriocapillaris atrophy, RPE and BrM abnormalities, culminating in areas of RPE loss and dramatic choroidal remodeling. Increased photoreceptor apoptosis in aged VEGF188/188 mice led to a decline in visual acuity as detected by electroretinogram (ERG). These changes are reminiscent of geographic atrophy (GA) and point to a role for RPE-derived VEGF in the maintenance of the choriocapillaris.
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Cites
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
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VEGF Inhibition and Renal Thrombotic Microangiopathy
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VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
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Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.
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Cited by
VEGF in signaling and disease: beyond discovery and development
Apte, R. S., Chen, D. S., & Ferrara, N. (2019) · Cell · doi:10.1016/j.cell.2019.01.021 · Cited by 2,721
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Datta, S., Cano, M., Ebrahimi, K., Wang, L., & Handa, J. T. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.03.002 · Cited by 802
Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials
Grunwald, J. E., Daniel, E., Huang, J., Ying, G.-S., Maguire, M. G., Toth, C. A., Jaffe, G. J., Fine, S. L., Blodi, B., Klein, M. L., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2013.08.015 · Cited by 590
Optical coherence tomography: Imaging of the choroid and beyond
Mrejen, S., & Spaide, R. F. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.12.001 · Cited by 477
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Metadata
- Authors
- Saint-Geniez, M., Kurihara, T., Sekiyama, E., Maldonado, A. E., & D'Amore, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-11-03
- Volume
- 106
- Issue
- 44
- Pages
- 18751-18756
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2076151830
- Cited by
- 530
- References
- 37
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Saint-Geniez, M., Kurihara, T., Sekiyama, E., Maldonado, A. E., & D'Amore, P. A. (2009). An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0905010106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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