The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Specific ER quality control components required for biogenesis of the plant innate immune receptor EFR
Open accessAbstract
Plant innate immunity depends in part on recognition of pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin, EF-Tu, and fungal chitin. Recognition is mediated by pattern-recognition receptors (PRRs) and results in PAMP-triggered immunity. EF-Tu and flagellin, and the derived peptides elf18 and flg22, are recognized in Arabidopsis by the leucine-rich repeat receptor kinases (LRR-RK), EFR and FLS2, respectively. To gain insights into the molecular mechanisms underlying PTI, we investigated EFR-mediated PTI using genetics. A forward-genetic screen for Arabidopsis elf18-insensitive (elfin) mutants revealed multiple alleles of calreticulin3 (CRT3), UDP-glucose glycoprotein glucosyl transferase (UGGT), and an HDEL receptor family member (ERD2b), potentially involved in endoplasmic reticulum quality control (ER-QC). Strikingly, FLS2-mediated responses were not impaired in crt3, uggt, and erd2b null mutants, revealing that the identified mutations are specific to EFR. A crt3 null mutant did not accumulate EFR protein, suggesting that EFR is a substrate for CRT3. Interestingly, Erd2b did not accumulate CRT3 protein, although they accumulate wild-type levels of other ER proteins. ERD2B seems therefore to be a specific HDEL receptor for CRT3 that allows its retro-translocation from the Golgi to the ER. These data reveal a previously unsuspected role of a specific subset of ER-QC machinery components for PRR accumulation in plant innate immunity.
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“In summary, mutations of GII or UGGT genes impair glycoprotein folding and cause ER retention and/or degradation with loss of function [10,385].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [385]
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Cites
Floral dip: a simplified method for Agrobacterium ‐mediated transformation of Arabidopsis thaliana
Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 22,014
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Self-citationPlant pathogens and integrated defence responses to infection
Dangl, J. L., & Jones, J. D. G. (2001) · Nature · doi:10.1038/35081161 · Cited by 3,959
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
Chisholm, S. T., Coaker, G., Day, B., & Staskawicz, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.008 · Cited by 2,957
Gómez‐Gómez, L., & Boller, T. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80265-8 · Cited by 2,319
Nelson, B. K., Cai, X., & Nebenführ, A. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03212.x · Cited by 2,086
Zipfel, C., Kunze, G., Chinchilla, D., Caniard, A., Jones, J. D. G., Boller, T., & Felix, G. (2006) · Cell · doi:10.1016/j.cell.2006.03.037 · Cited by 2,068
A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nürnberger, T., Jones, J. D. G., Felix, G., & Boller, T. (2007) · Nature · doi:10.1038/nature05999 · Cited by 1,923
Bacterial disease resistance in Arabidopsis through flagellin perception
Zipfel, C., Robatzek, S., Navarro, L., Oakeley, E. J., Jones, J. D. G., Felix, G., & Boller, T. (2004) · Nature · doi:10.1038/nature02485 · Cited by 1,793
Plants have a sensitive perception system for the most conserved domain of bacterial flagellin
Felix, G., Duran, J. D., Volko, S. M., & Boller, T. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00265.x · Cited by 1,719
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Dodds, P. N., & Rathjen, J. P. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2812 · Cited by 3,539
Oldroyd, G. E. D. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2990 · Cited by 1,773
Conrath, U., Beckers, G. J. M., Langenbach, C. J. G., & Jaskiewicz, M. R. (2015) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080614-120132 · Cited by 1,117
Roux, M. E., Schwessinger, B., Albrecht, C., Chinchilla, D., Jones, A. M. E., Holton, N. J., Malinovsky, F. G., Tör, M., de Vries, S. C., & Zipfel, C. (2011) · The Plant Cell · doi:10.1105/tpc.111.084301 · Cited by 716
Endoplasmic Reticulum Stress Responses in Plants
Howell, S. H. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120053 · Cited by 568
Metadata
- Authors
- Li, J., Zhao-Hui, C., Batoux, M., Nekrasov, V., Roux, M., Chinchilla, D., Zipfel, C., & Jones, J. D. G.
- Affiliations
- Norwich Research Park (GB)
- University of Basel (CH)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-09-15
- Volume
- 106
- Issue
- 37
- Pages
- 15973-15978
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2747228
- OpenAlex
- W2129355294
- Cited by
- 273
- References
- 58
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 19 · 2021: 20 · 2020: 14 · 2019: 16 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 18 · 2014: 22 · 2013: 17 · 2012: 27
- FWCI
- 31.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/F021046/1, BB/E024874/1)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- endoplasmic reticulum quality control, plant innate immunity, pattern-triggered immunity, protein accumulation, leucine-rich repeat receptor-like kinases, Arabidopsis thaliana, elf18, flg22, FLS2
- MeSH terms
- Alleles, Base Sequence, Endoplasmic Reticulum, Glucosyltransferases, Immunity, Innate, Membrane Proteins, Mutation, Plant Diseases, Protein Kinases, Signal Transduction, Genes, Plant, Arabidopsis, DNA Primers, Arabidopsis Proteins, Plants, Genetically Modified, Calreticulin, Pseudomonas syringae, Host-Pathogen Interactions
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