Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery?
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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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“Some data suggest that taxon-specific glycan losses may have played a role in protection from parasites like malaria (732, 1055), and even in speciation events, such as the origin of the genus Homo (943).”
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- Authors
- Varki, A., & Gagneux, P.
- Affiliations
- University of California San Diego (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-09
- Volume
- 106
- Issue
- 35
- Pages
- 14739-14740
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2736437
- OpenAlex
- W2144119406
- Cited by
- 62
- References
- 15
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- sialic acid, sialic acid receptors, Plasmodium falciparum, Plasmodium malariae, Plasmodium reichenowi, Plasmodium knowlesi, Plasmodium yoelii, Plasmodium vivax
- MeSH terms
- Animals, Pan troglodytes, Biological Evolution, Host-Parasite Interactions, Humans, Malaria, Membrane Glycoproteins, Plasmodium, Plasmodium falciparum, Protozoan Infections, Animal, Protozoan Proteins, N-Acetylneuraminic Acid
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