The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)
Open accessAbstract
The herbicide atrazine is one of the most commonly applied pesticides in the world. As a result, atrazine is the most commonly detected pesticide contaminant of ground, surface, and drinking water. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations. Previous studies showed that atrazine adversely affects amphibian larval development. The present study demonstrates the reproductive consequences of atrazine exposure in adult amphibians. Atrazine-exposed males were both demasculinized (chemically castrated) and completely feminized as adults. Ten percent of the exposed genetic males developed into functional females that copulated with unexposed males and produced viable eggs. Atrazine-exposed males suffered from depressed testosterone, decreased breeding gland size, demasculinized/feminized laryngeal development, suppressed mating behavior, reduced spermatogenesis, and decreased fertility. These data are consistent with effects of atrazine observed in other vertebrate classes. The present findings exemplify the role that atrazine and other endocrine-disrupting pesticides likely play in global amphibian declines.
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Cites
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Self-citationEcological risk assessment of atrazine in North American surface waters
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Self-citationA W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis
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Cited by
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
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Wildlife Ecotoxicology of Pesticides: Can We Track Effects to the Population Level and Beyond?
Köhler, H.-R., & Triebskorn, R. (2013) · Science · doi:10.1126/science.1237591 · Cited by 911
Diversification practices reduce organic to conventional yield gap
Ponisio, L. C., M'Gonigle, L. K., Mace, K. C., Palomino, J., de Valpine, P., & Kremen, C. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.1396 · Cited by 871
Environmental immune disruptors, inflammation and cancer risk
Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S. A., Moon, E.-Y., Al-Mulla, F., Al-Temaimi, R., Brown, D. G., Colacci, A. M., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv038 · Cited by 227
Metadata
- Authors
- Hayes, T. B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., Adame, L., Chan, E., Buchholz, D., Stueve, T., & Gallipeau, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-03-09
- Volume
- 107
- Issue
- 10
- Pages
- 4612-4617
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070908085
- Cited by
- 608
- References
- 49
- FWCI
- 27.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Hayes, T. B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., Adame, L., Chan, E., Buchholz, D., Stueve, T., & Gallipeau, S. (2010). Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0909519107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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