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Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
Open accessAbstract
Atrazine is the most commonly used herbicide in the United States and probably the world. Atrazine contamination is widespread and can be present in excess of 1.0 ppb even in precipitation and in areas where it is not used. In the current study, we showed that atrazine exposure (> or = to 0.1 ppb) resulted in retarded gonadal development (gonadal dysgenesis) and testicular oogenesis (hermaphroditism) in leopard frogs (Rana pipiens). Slower developing males even experienced oocyte growth (vitellogenesis). Furthermore, we observed gonadal dysgenesis and hermaphroditism in animals collected from atrazine-contaminated sites across the United States. These coordinated laboratory and field studies revealed the potential biological impact of atrazine contamination in the environment. Combined with reported similar effects in Xenopus laevis, the current data raise concern about the effects of atrazine on amphibians in general and the potential role of atrazine and other endocrine-disrupting pesticides in amphibian declines.
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Cited by
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Self-citationHayes, T. B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., Adame, L., Chan, E., Buchholz, D., Stueve, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909519107 · Cited by 608
Self-citationRani, M., Shanker, U., & Jassal, V. (2017) · Journal of Environmental Management · doi:10.1016/j.jenvman.2016.12.068 · Cited by 319
Metadata
- Authors
- Hayes, T., Haston, K., Tsui, M., Hoang, A., Haeffele, C., & Vonk, A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-04
- Volume
- 111
- Issue
- 4
- Pages
- 568-575
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2109950926
- Cited by
- 606
- References
- 0
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. https://app.cochat.ai/papers/10.1289/ehp.5932
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- Hayes, T., Haston, K., Tsui, M., Hoang, A., Haeffele, C., & Vonk, A. (2003). Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. Environmental Health Perspectives. https://doi.org/10.1289/ehp.5932
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