The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure
Open accessAbstract
Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate in vitro that acetaminophen inhibits hemoprotein-induced lipid peroxidation by reducing ferryl heme to its ferric state and quenching globin radicals. Severe muscle injury (rhabdomyolysis) is accompanied by the release of myoglobin that becomes deposited in the kidney, causing renal injury. We previously showed in a rat model of rhabdomyolysis that redox cycling between ferric and ferryl myoglobin yields radical species that cause severe oxidative damage to the kidney. In this model, acetaminophen at therapeutic plasma concentrations significantly decreased oxidant injury in the kidney, improved renal function, and reduced renal damage. These findings also provide a hypothesis for potential therapeutic applications for acetaminophen in diseases involving hemoprotein-mediated oxidative injury.
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Cites
Acetaminophen Toxicity in an Urban County Hospital
Schiødt, F. V., Rochling, F. A., Casey, D. L., & Lee, W. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371602 · Cited by 422
Boutaud, O., Aronoff, D. M., Richardson, J. H., Marnett, L. J., & Oates, J. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102588199 · Cited by 209
Self-citationMechanism of Acetaminophen Inhibition of Cyclooxygenase Isoforms
Ouellet, M., & Percival, M. D. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2232 · Cited by 166
Modification of anti-inflammatory drug effectiveness by ambient lipid peroxides
Hanel, A. M., & Lands, W. E. M. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90565-2 · Cited by 95
Cited by
Graham, G. G., Davies, M. J., Day, R. O., Mohamudally, A., & Scott, K. F. (2013) · Inflammopharmacology · doi:10.1007/s10787-013-0172-x · Cited by 671
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury
Jiang, D., Ge, Z., Im, H.-J., England, C. G., Ni, D., Hou, J., Zhang, L., Kutyreff, C. J., Yan, Y., Liu, Y., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0317-8 · Cited by 447
Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review
Petejova, N., & Martinek, A. (2014) · Critical Care · doi:10.1186/cc13897 · Cited by 444
Zimmerman, J. L., & Shen, M. C. (2013) · Chest · doi:10.1378/chest.12-2016 · Cited by 346
Clinical trials in acute respiratory distress syndrome: challenges and opportunities
Matthay, M. A., McAuley, D. F., & Ware, L. B. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30188-1 · Cited by 284
Metadata
- Authors
- Boutaud, O., Moore, K. P., Reeder, B. J., Harry, D., Howie, A. J., Wang, S., Carney, C. K., Masterson, T. S., Amin, T., Wright, D. W., Wilson, M. T., Oates, J. A., & Roberts, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-02
- Volume
- 107
- Issue
- 6
- Pages
- 2699-2704
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2121894911
- Cited by
- 184
- References
- 4
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Boutaud, O., Moore, K. P., Reeder, B. J., Harry, D., Howie, A. J., Wang, S., Carney, C. K., Masterson, T. S., Amin, T., Wright, D. W., Wilson, M. T., Oates, J. A., & Roberts, L. J. (2010). Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0910174107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
