The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
Open accessAbstract
Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the α-helical central rod domain required for the polymerization of the nuclear lamins into higher order structures. Patient cells with a mutation in this domain, 433G>A (E145K) show severely lobulated nuclei, a separation of the A- and B-type lamins, alterations in pericentric heterochromatin, abnormally clustered centromeres, and mislocalized telomeres. The induction of lobulations and the clustering of centromeres originate during postmitotic nuclear assembly in daughter cells and this early G1 configuration of chromosomes is retained throughout interphase. In vitro analyses of E145K-lamin A show severe defects in the assembly of protofilaments into higher order lamin structures. The results show that this central rod domain mutation affects nuclear architecture in a fashion distinctly different from the changes found in the most common form of progeria caused by the expression of LAΔ50/progerin. The study also emphasizes the importance of lamins in nuclear assembly and chromatin organization.
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., & Stein, H. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.4.1710 · Cited by 4,173
Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103
Self-citationMutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791
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Cited by
The role of nuclear lamin B1 in cell proliferation and senescence
Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes & Development · doi:10.1101/gad.179515.111 · Cited by 547
Self-citationShah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550
Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
Stephens, A. D., Banigan, E. J., Adam, S. A., Goldman, R. D., & Marko, J. F. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0653 · Cited by 473
Self-citationDechat, T., Adam, S. A., Taimen, P., Shimi, T., & Goldman, R. D. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000547 · Cited by 379
Self-citationChromatin histone modifications and rigidity affect nuclear morphology independent of lamins
Stephens, A. D., Liu, P. Z., Banigan, E. J., Almassalha, L. M., Backman, V., Adam, S. A., Goldman, R. D., & Marko, J. F. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0410 · Cited by 353
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Metadata
- Authors
- Taimen, P., Pfleghaar, K., Shimi, T., Möller, D., Ben-Harush, K., Erdos, M. R., Adam, S. A., Herrmann, H., Medalia, O., Collins, F. S., Goldman, A. E., & Goldman, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-12-08
- Volume
- 106
- Issue
- 49
- Pages
- 20788-20793
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2112757893
- Cited by
- 211
- References
- 4
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Taimen, P., Pfleghaar, K., Shimi, T., Möller, D., Ben-Harush, K., Erdos, M. R., Adam, S. A., Herrmann, H., Medalia, O., Collins, F. S., Goldman, A. E., & Goldman, R. D. (2009). A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0911895106
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