Nuclear Lamins
Open accessAbstract
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.
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Progerin is a truncated lamin A with a hydrophobic farnesylated C-terminal.
“The aberrantly processed protein produced is called progerin, a truncated form of lamin A with a hydrophobic farnesylated C-terminal 105–112.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [105]
HGPS patients suffer laminopathy due to a sporadic deficiency in proteolytic processing of prelamin A into mature lamin A.
“Hutchison-Gilford progeria syndrome (HGPS) patients suffer from a variety of laminopathy ailments due to a sporadic deficiency in the proteolytic processing of the precursor form of lamin A into the mature protein.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [105]
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Cites
Genomic instability in laminopathy-based premature aging
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650 · see citing works
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Research works printed but not linked: 2
- Malhas A, Lee CF, Sanders R, Saunders NJ, Vaux DJ. 2007. Defects in lamin B1 expression or processing affect inter- phase chromosome position and gene expression. J Cell Biol 176: 593 -603.
- Muchir A, van Engelen BG, Lammens M, Mislow JM, McNally E, Schwartz K, Bonne G. 2003. Nuclear envelope Nuclear Lamins Cite this article as Cold Spring Harb Perspect Biol 2010;2:a000547 alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene. Exp Cell Res 291: 352 -362.
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Local translation of extranuclear lamin B promotes axon maintenance
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Myant, K., Qiao, X., Halonen, T., Come, C., Laine, A., Janghorban, M., Partanen, J. I., Cassidy, J., Ogg, E.-L., Cammareri, P., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.003 · Cited by 59 · see citing works
Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage
Etourneaud, L., Moussa, A., Rass, E., Genet, D., Willaume, S., Chabance-Okumura, C., Wanschoor, P., Picotto, J., Thézé, B., Dépagne, J., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb3799 · Cited by 54 · see citing works
Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture
Donohoe, C. D., Csordás, G., Correia, A., Jindra, M., Klein, C., Habermann, B., & Uhlirova, M. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007241 · Cited by 32 · see citing works
Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23 · see citing works
- Authors
- Dechat, T., Adam, S. A., Taimen, P., Shimi, T., & Goldman, R. D.
- Affiliations
- Northwestern University (US)
- University of Turku (FI)
- Corresponding author
- Goldman, R. D.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-09-08
- Volume
- 2
- Issue
- 11
- Pages
- a000547-a000547
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC2964183
- OpenAlex
- W4211059758
- Cited by
- 379
- References
- 1
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 18 · 2023: 17 · 2022: 28 · 2021: 23 · 2020: 28 · 2019: 26 · 2018: 23 · 2017: 23 · 2016: 42 · 2015: 21 · 2014: 21 · 2013: 34 · 2012: 33
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suomen Kulttuurirahasto
- Syöpäjärjestöt
- Orionin Tutkimussäätiö
- National Institute on Aging
- National Cancer Institute (R01CA031760)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- nuclear lamins, intermediate filaments, nuclear lamina, nuclear structure, chromatin organization, DNA replication, transcriptional regulation, post-translational modification, mitosis, cell cycle, cell differentiation, chromatin modification, chromosome spatial organization
- MeSH terms
- Animals, Cell Cycle, Cell Nucleus, Chromatin, Cytoskeleton, DNA Replication, Humans, Protein Processing, Post-Translational, Lamins
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