The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A protein secretion system linked to bacteroidete gliding motility and pathogenesis
Open accessAbstract
Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Protein secretion systems common to other Gram-negative bacteria are lacking in P. gingivalis , but several proteins, including PorT, have been linked to gingipain secretion. Comparative genome analysis and genetic experiments revealed 11 additional proteins involved in gingipain secretion. Six of these (PorK, PorL, PorM, PorN, PorW, and Sov) were similar in sequence to Flavobacterium johnsoniae gliding motility proteins, and two others (PorX and PorY) were putative two-component system regulatory proteins. Real-time RT-PCR analysis revealed that porK , porL , porM , porN , porP , porT , and sov were down-regulated in P. gingivalis porX and porY mutants. Disruption of the F. johnsoniae porT ortholog resulted in defects in motility, chitinase secretion, and translocation of a gliding motility protein, SprB adhesin, to the cell surface, providing a link between a unique protein translocation system and a motility apparatus in members of the Bacteroidetes phylum.
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Self-citationRole of bacterial proteinases in matrix destruction and modulation of host responses
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Self-citationRelationship Between Quorum Sensing and Secretion Systems
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Lack of a surface layer in Tannerella forsythia mutants deficient in the type IX secretion system
Narita, Y., Sato, K., Yukitake, H., Shoji, M., Nakane, D., Nagano, K., Yoshimura, F., Naito, M., & Nakayama, K. (2014) · Microbiology · doi:10.1099/mic.0.080192-0 · Cited by 59
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Metadata
- Authors
- Sato, K., Naito, M., Yukitake, H., Hirakawa, H., Shoji, M., McBride, M. J., Rhodes, R. G., & Nakayama, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-12-29
- Volume
- 107
- Issue
- 1
- Pages
- 276-281
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964516944
- Cited by
- 374
- References
- 31
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
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