Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the ‘red complex’, a prototype polybacterial pathogenic consortium in periodontitis
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Over 250 species from the oral cavity have been isolated in culture and characterized, including key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, involved in the etiology of dental caries and periodontal disease.
“Over 250 species from the oral cavity have been isolated in culture and characterized, including several key pathogens, such as Streptococcus mutans, Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, involved in the etiology of dental caries and periodontal disease.7, 8, 9”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [7]
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Fixed Prosthetic Restorations and Periodontal Health: A Narrative Review
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Lack of a surface layer in Tannerella forsythia mutants deficient in the type IX secretion system
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- Authors
- Holt, S. C., & Ebersole, J. L.
- Affiliations
- The Forsyth Institute (US)
- University of Kentucky (US)
- ORCID
- Ebersole, Jeffrey L.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2005-04-21
- Volume
- 38
- Issue
- 1
- Pages
- 72-122
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W2061948662
- Cited by
- 932
- References
- 475
- Citations by year
- 2026: 39 · 2025: 36 · 2024: 48 · 2023: 49 · 2022: 59 · 2021: 63 · 2020: 61 · 2019: 52 · 2018: 46 · 2017: 49 · 2016: 47 · 2015: 51 · 2014: 61 · 2013: 47 · 2012: 42
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Periodontology 2000 (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03de013598-02)
- National Institute of Dental and Craniofacial Research (DE 14896, DE 13598, R01DE011368, DE-11368, R01DE015720, R21DE014896, DE 15720)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, red complex, periodontitis, periodontal pathogens, bacterial interactions
- MeSH terms
- Animals, Bacteroides, Disease Models, Animal, Humans, Periodontitis, Porphyromonas gingivalis, Ecosystem, Virulence Factors, Treponema denticola
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