The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Macrophage Wnt7b is critical for kidney repair and regeneration
Open accessAbstract
Macrophages are required for tissue homeostasis through their role in regulation of the immune response and the resolution of injury. Here we show, using the kidney as a model, that the Wnt pathway ligand Wnt7b is produced by macrophages to stimulate repair and regeneration. When macrophages are inducibly ablated from the injured kidney, the canonical Wnt pathway response in kidney epithelial cells is reduced. Furthermore, when Wnt7b is somatically deleted in macrophages, repair of injury is greatly diminished. Finally, injection of the Wnt pathway regulator Dkk2 enhances the repair process and suggests a therapeutic option. Because Wnt7b is known to stimulate epithelial responses during kidney development, these findings suggest that macrophages are able to rapidly invade an injured tissue and reestablish a developmental program that is beneficial for repair and regeneration.
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Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649
Self-citationKato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086
Self-citationKremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800
Metchnikoff and the phagocytosis theory
Tauber, A. I. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1244 · Cited by 413
Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling
Mao, B., & Niehrs, C. (2003) · Gene · doi:10.1016/s0378-1119(02)01106-x · Cited by 325
Cited by
Distinct macrophage phenotypes contribute to kidney injury and repair
Lee, S., Huen, S., Nishio, H., Nishio, S., Lee, H. K., Choi, B.-S., Ruhrberg, C., & Cantley, L. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060615 · Cited by 906
Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2667 · Cited by 747
Macrophages in inflammation, repair and regeneration
Oishi, Y., & Manabe, I. (2018) · International Immunology · doi:10.1093/intimm/dxy054 · Cited by 734
MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways
Chau, B. N., Xin, C., Hartner, J., Ren, S., Castano, A. P., Linn, G., Li, J., Tran, P. T., Kaimal, V., Huang, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003205 · Cited by 587
Self-citationTissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
Metadata
- Authors
- Lin, S.-L., Li, B., Rao, S., Yeo, E.-J., Hudson, T. E., Nowlin, B. T., Pei, H., Chen, L., Zheng, J. J., Carroll, T. J., Pollard, J. W., McMahon, A. P., Lang, R. A., & Duffield, J. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-02-16
- Volume
- 107
- Issue
- 9
- Pages
- 4194-4199
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053402030
- Cited by
- 424
- References
- 9
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, S.-L., Li, B., Rao, S., Yeo, E.-J., Hudson, T. E., Nowlin, B. T., Pei, H., Chen, L., Zheng, J. J., Carroll, T. J., Pollard, J. W., McMahon, A. P., Lang, R. A., & Duffield, J. S. (2010). Macrophage Wnt7b is critical for kidney repair and regeneration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0912228107
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