Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444 · see citing works

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

Kořínek, V., Barker, N., Morin, P. J., van Wichen, D. F., de Weger, R. A., Kinzler, K. W., Vogelstein, B., & Clevers, H. C. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 3,304 · see citing works

Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units

PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258 · see citing works

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,540 · see citing works

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504 · see citing works

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semënov, M. V., Kato, Y., Spokony, R. F., Liu, C., Katsuyama, Y., Hess, F. J., Saint‐Jeannet, J., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,334 · see citing works

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282 · see citing works

Female development in mammals is regulated by Wnt-4 signalling

Vainio, S. J., Heikkilä, M. M., Kispert, A., Chin, N., & McMahon, A. P. (1999) · Nature · doi:10.1038/17068 · Cited by 1,263 · see citing works

LRP: a multifunctional scavenger and signaling receptor

Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13992 · Cited by 1,094 · see citing works

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086 · see citing works

LRP: a multifunctional scavenger and signaling receptor

Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113992 · Cited by 906 · see citing works

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 3× · see citing works

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentPreprint

Ducy, P. F., Starbuck, M., Priemel, M., Shen, J., Pinero, G. J., Geoffroy, V., Amling, M., & Karsenty, G. (1999) · Genes & Development · doi:10.1101/gad.13.8.1025 · Cited by 772 · see citing works

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinPreprint

Merrill, B. J., Gat, U., DasGupta, R., & Fuchs, E. V. (2001) · Genes & Development · doi:10.1101/gad.891401 · Cited by 559 · see citing works

New aspects of Wnt signaling pathways in higher vertebrates

Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 552 · see citing works

Wnt-14 Plays a Pivotal Role in Inducing Synovial Joint Formation in the Developing Appendicular Skeleton

Hartmann, C., & Tabin, C. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00222-7 · Cited by 491 · see citing works

Dual roles of Wnt signaling during chondrogenesis in the chicken limb

Hartmann, C., & Tabin, C. J. (2000) · Development · doi:10.1242/dev.127.14.3141 · Cited by 472 · see citing works

THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY

Hussain, M. M., Strickland, D. K., & Bakillah, A. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.141 · Cited by 376 · see citing works

Macrophages are required for cell death and tissue remodeling in the developing mouse eye

Lang, R. A., & Bishop, J. M. (1993) · Cell · doi:10.1016/0092-8674(93)80047-i · Cited by 366 · see citing works

Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a

Parr, B. A., & McMahon, A. P. (1998) · Nature · doi:10.1038/27221 · Cited by 358 · see citing works

The genetic transformation of bone biologyPreprint

Karsenty, G. (1999) · Genes & Development · doi:10.1101/gad.13.23.3037 · Cited by 307 · see citing works

Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid

Kochhar, D. M. (1973) · Teratology · doi:10.1002/tera.1420070310 · Cited by 288 · see citing works

Dynamic histomorphometry of alveolar bone remodeling in the adult rat

Vignery, A., & Baron, R. (1980) · The Anatomical Record · doi:10.1002/ar.1091960210 · Cited by 260 · see citing works

Cytoskeletal reorganization by soluble Wnt‐3a protein signalling

Shibamoto, Higano, K., Takada, R., Ito, F., Takeichi, M., & Takada, S. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00221.x · Cited by 251 · see citing works

Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13.

Gong, Y., Vikkula, M., Boon, L. M., Liu, J., Beighton, P., Ramesar, R., Peltonen, L., Somer, H., Hirose, T., Dallapiccola, B., et al. (1996) · PubMed Central · Cited by 245 · see citing works

Cloning of a novel member of the low-density lipoprotein receptor family

Hey, P. J., Twells, R. C. J., Phillips, M. S., Nakagawa, Y., Brown, S. D., Kawaguchi, Y., Cox, R., Xie, G., Dugan, V., Hammond, H. A., et al. (1998) · Gene · doi:10.1016/s0378-1119(98)00311-4 · Cited by 224 · see citing works

Apolipoprotein E receptors: linking brain development and alzheimer's disease

Herz, J., & Beffert, U. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036221 · Cited by 219 · see citing works

Regression of the hyaloid vessels and pupillary membrane of the mouse

Ito, M., & Yoshioka, M. (1999) · Anatomy and Embryology · doi:10.1007/s004290050289 · Cited by 217 · see citing works

Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene Family

Brown, S. D., Twells, R. C. J., Hey, P. J., Cox, R., Levy, E. R., Soderman, A. R., Metzker, M. L., Caskey, C. T., Todd, J. A., & Hess, J. F. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9061 · Cited by 211 · see citing works

Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member

Yamazaki, H., Bujo, H., Kusunoki, J., Seimiya, K., Kanaki, T., Morisaki, N., Schneider, W. J., & Saitō, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24761 · Cited by 204 · see citing works

Apoptosis during macrophage-dependent ocular tissue remodelling

Lang, R. A., Lustig, M., Francois, F., Sellinger, M., & Plesken, H. (1994) · Development · doi:10.1242/dev.120.12.3395 · Cited by 165 · see citing works

The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism

Willnow, T. E. (1999) · Journal of Molecular Medicine · doi:10.1007/s001090050356 · Cited by 164 · see citing works

Macrophages induce apoptosis in normal cells in vivo

Diez‐Roux, G., & Lang, R. A. (1997) · Development · doi:10.1242/dev.124.18.3633 · Cited by 154 · see citing works

A relationship between apoptosis and flow during programmed capillary regression is revealed by vital analysis

Meeson, A. P., Palmer, M. A. J., Calfon, M. A., & Lang, R. A. (1996) · Development · doi:10.1242/dev.122.12.3929 · Cited by 139 · see citing works

Negative Feedback Mechanisms and Their Roles during Pattern Formation

Perrimon, N., & McMahon, A. P. (1999) · Cell · doi:10.1016/s0092-8674(00)80710-2 · Cited by 130 · see citing works

A New Low Density Lipoprotein Receptor Related Protein, LRP5, Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E

Kim, D., Inagaki, Y., SUZUKI, T. A., Ioka, R. X., Yoshioka, S. Z., Magoori, K., Kang, M., Cho, Y., Nakano, A. Z., Liu, Q., et al. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022223 · Cited by 116 · see citing works

Apoptosis in mammalian eye development: lens morphogenesis, vascular regression and immune privilege

Lang, R. A. (1997) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400211 · Cited by 77 · see citing works

Molecular Cloning and Characterization of LR3, a Novel LDL Receptor Family Protein with Mitogenic Activity

Yu, D. L., Lathrop, W. F., Weaver, D. R., Qiu, Q., Cini, J. K., Bertolini, D. R., & Chen, D. J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9545 · Cited by 73 · see citing works

Determinants of peak bone mass

Johnston, C. C., & Slemenda, C. W. (1993) · Osteoporosis International · doi:10.1007/bf01621864 · Cited by 66 · see citing works

Expression of the Type I Diabetes-associated Gene LRP5 in Macrophages, Vitamin A System Cells, and the Islets of Langerhans Suggests Multiple Potential Roles in Diabetes

Figueroa, D. J., Hess, J. F., Ky, B., Brown, S. D., Sandig, V., Hermanowski‐Vosatka, A., Twells, R. C. J., Todd, J. A., & Austin, C. P. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004801006 · Cited by 64 · see citing works

A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart

Tomita, Y., Kim, D. H., Magoori, K., Fujino, T., & Yamamoto, T. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022180 · Cited by 53 · see citing works

cDNA Cloning of a New Low-Density Lipoprotein Receptor-Related Protein and Mapping of Its Gene (LRP3) to Chromosome Bands 19q12–q13.2

Ishii, H., Kim, D.-H., Fujita, T., Endo, Y., Saeki, S., & Yamamoto, T. (1998) · Genomics · doi:10.1006/geno.1998.5339 · Cited by 46 · see citing works

Staining of the calcification front in human bone using contrasting fluorochromes in vitro.

Aaron, J. E., Makins, N. B., Francis, R. M., & Peacock, M. (1984) · Journal of Histochemistry & Cytochemistry · doi:10.1177/32.12.6209330 · Cited by 39 · see citing works

Osteoporosis‐pseudoglioma or osteogenesis imperfecta?

Superti‐Furga, A., Steinmann, B., & Perfumo, F. (1986) · Clinical Genetics · doi:10.1111/j.1399-0004.1986.tb01249.x · Cited by 12 · see citing works

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works

Wnt/β-catenin signaling and disease

Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554 · see citing works

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519 · see citing works

WNT signaling in bone homeostasis and disease: From human mutations to treatments

Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093 · see citing works

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616 · see citing works

Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,594 · see citing works

Secreted antagonists of the Wnt signalling pathway

Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584 · see citing works

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,499 · see citing works

Control of osteoblast function and regulation of bone mass

Harada, S.-I., & Rodan, G. A. (2003) · Nature · doi:10.1038/nature01660 · Cited by 1,451 · see citing works

Regulation of bone mass by Wnt signaling

Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407 · see citing works

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350 · see citing works

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · see citing works

Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170 · see citing works

Building strong bones: molecular regulation of the osteoblast lineage

Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,149 · see citing works

Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,086 · see citing works

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works

Distinct roles for Hedgehog and canonical Wnt signaling in specification,differentiation and maintenance of osteoblast progenitors

Rodda, S. J., & McMahon, A. P. (2006) · Development · doi:10.1242/dev.02480 · Cited by 1,011 · see citing works

Function and biological roles of the Dickkopf family of Wnt modulators

Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995 · see citing works

Vascular Development in the Retina and Inner Ear

Xu, Q., Wang, Y., Dabdoub, A., Smallwood, P. M., Williams, J., Woods, C., Kelley, M. W., Jiang, L., Tasman, W., Zhang, K., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00216-8 · Cited by 875 · see citing works

Regulation of osteoblastogenesis and bone mass by Wnt10b

Bennett, C. N., Longo, K. A., Hahn, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., & MacDougald, O. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408742102 · Cited by 882 · see citing works

Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton

CANALIS, E. M., Economides, A. N., & Gazzerro, E. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0023 · Cited by 861 · see citing works

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

Yadav, V. K., Ryu, J.-H., Suda, N., Tanaka, K. F., Gingrich, J. A., Schütz, G., Glorieux, F. H., Chiang, C. Y., Zajac, J. D., Insogna, K. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.059 · Cited by 837 · see citing works

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822 · see citing works

Wnt signaling in osteoblasts and bone diseases

Westendorf, J. J., Kahler, R. A., & Schroeder, T. M. (2004) · Gene · doi:10.1016/j.gene.2004.06.044 · Cited by 805 · see citing works

Adult mesenchymal stem cells and cell-based tissue engineering.

Tuan, R. S., Boland, G. M., & Tuli, R. (2003) · Arthritis Research · doi:10.1186/ar614 · Cited by 780 · see citing works

BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop

Rawadi, G., Vayssière, B., Dunn, F. W., Baron, R., & Roman‐Roman, S. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.10.1842 · Cited by 763 · see citing works

OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J., & Choi, Y. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090646 · Cited by 724 · see citing works

TSH Is a Negative Regulator of Skeletal Remodeling

Abe, E., Marians, R. C., Yu, W., Wu, X.-B., Ando, T., Li, Y., Iqbal, J., Eldeiry, L., Rajendren, G., Blair, H. C., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00771-2 · Cited by 691 · see citing works

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682 · see citing works

Development of the Endochondral SkeletonPreprint

Long, F., & Ornitz, D. M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008334 · Cited by 665 · see citing works

Signaling and transcriptional regulation in osteoblast commitment and differentiation

Huang, W. (2007) · Frontiers in bioscience · doi:10.2741/2296 · Cited by 649 · see citing works

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

Yu, K., Xu, J.-S., Liu, Z.-H., Šošić, D., Shao, J.-S., Olson, E., Towler, D., & Ornitz, D. (2003) · Development · doi:10.1242/dev.00491 · Cited by 654 · see citing works

The cell biology of bone metabolism

Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614 · see citing works

Osteoblasts in prostate cancer metastasis to bone

Logothetis, C. J., & Lin, S.-H. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1528 · Cited by 613 · see citing works

SNPs: Impact on Gene Function and Phenotype

Shastry, B. S. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-411-1_1 · Cited by 596 · see citing works

Essential role of β-catenin in postnatal bone acquisition.

Holmen, S. L., Zylstra, C. R., Mukherjee, A., Sigler, R. E., Faugere, M.-C., Bouxsein, M. L., Deng, L., Clemens, T. L., & Williams, B. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501900200 · Cited by 584 · see citing works

Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton

Baron, R., & Rawadi, G. (2007) · Endocrinology · doi:10.1210/en.2007-0270 · Cited by 584 · see citing works

The Molecular Clock Mediates Leptin-Regulated Bone Formation

Fu, L., Patel, M. S., Bradley, A., Wagner, E. F., & Karsenty, G. (2005) · Cell · doi:10.1016/j.cell.2005.06.028 · Cited by 575 · see citing works

The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

Tyagi, A. M., Yu, M., Darby, T. M., Vaccaro, C., Li, J., Owens, J. A., Hsu, E., Adams, J., Weitzmann, M. N., Jones, R. M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.013 · Cited by 575 · see citing works

Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells

Boland, G. M., Perkins, G., Hall, D. J., & Tuan, R. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20284 · Cited by 568 · see citing works

Osteoimmunology: Interactions of the Bone and Immune System

Lorenzo, J., Horowitz, M. C., & Choi, Y. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0038 · Cited by 566 · see citing works

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis

Krämer, I., Halleux, C. M., Keller, H., Pegurri, M., Gooi, J. H., Weber, P. B., Feng, J. Q., Bonewald, L. F., & Kneissel, M. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01428-09 · Cited by 562 · see citing works

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2653 · Cited by 542 · see citing works

A Mechanism for Wnt Coreceptor Activation

Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., & He, X. (2004) · Molecular Cell · doi:10.1016/s1097-2765(03)00484-2 · Cited by 556 · see citing works

The contribution of bone to whole-organism physiology

Karsenty, G., & Ferron, M. (2012) · Nature · doi:10.1038/nature10763 · Cited by 537 · see citing works

Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting β-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription

Almeida, M., Li, H., Martín-Millán, M., O’Brien, C. A., & Manolagas, S. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702811200 · Cited by 546 · see citing works

Peripheral cannabinoid receptor, CB2, regulates bone mass

Ofek, O., Karsak, M., Leclerc, N., Fogel, M., Frenkel, B., Wright, K. L., Tam, J., Attar-Namdar, M., Kram, V., Shohami, E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504187103 · Cited by 536 · see citing works

An overview of the regulation of bone remodelling at the cellular level

Kular, J., Tickner, J. C., Chim, S. M., & Xu, J. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.03.021 · Cited by 536 · see citing works

Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement

Siddiqui, J. A., & Partridge, N. C. (2016) · Physiology · doi:10.1152/physiol.00061.2014 · Cited by 546 · see citing works

Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis

Zhao, L., Jiang, H., Papasian, C. J., Maulik, D., Drees, B. M., Hamilton, J., & Deng, H. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070813 · Cited by 529 · see citing works

Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone

Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

Clément-Lacroix, P., Ai, M., Morvan, F., Roman‐Roman, S., Vayssière, B., Belleville, C., Estrera, K. A., Warman, M. L., Baron, R., & Rawadi, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505259102 · Cited by 520 · see citing works

Development of the retinal vasculature

Fruttiger, M. (2007) · Angiogenesis · doi:10.1007/s10456-007-9065-1 · Cited by 510 · see citing works

Playing with bone and fat

Gimble, J. M., Zvonic, S., Floyd, Z. E., Kassem, M. S., & NUTTALL, M. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20777 · Cited by 505 · see citing works

High Bone Mass in Mice Expressing a Mutant LRP5 Gene

Babij, P., Zhao, W., Small, C. G., Kharode, Y. P., Yaworsky, P. J., Bouxsein, M., Reddy, P. S., Bodine, P. V. N., Robinson, J. A., Bhat, B. M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 497 · see citing works

Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density

Van Wesenbeeck, L., Cleiren, E., Gram, J., Beals, R. K., Bénichou, O., Scopelliti, D., Key, L., Renton, T., Bartels, C., Gong, Y., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/368277 · Cited by 568 · see citing works

Wnt signaling: complexity at the surface

Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486 · see citing works

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Zhu, S., Chen, W., Masson, A., & Li, Y. (2024) · Cell Discovery · doi:10.1038/s41421-024-00689-6 · Cited by 513 · see citing works

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

Ye, X., Wang, Y., Cahill, H. B., Yu, M., Badea, T. C., Smallwood, P. M., Peachey, N. S., & Nathans, J. (2009) · Cell · doi:10.1016/j.cell.2009.07.047 · Cited by 472 · see citing works

Networks and hubs for the transcriptional control of osteoblastogenesis

Lian, J. B., Stein, G. S., Javed, A., van Wijnen, A. J., Stein, J. L., Montecino, M. A., Hassan, M. Q., Gaur, T., Lengner, C. J., & Young, D. W. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9001-5 · Cited by 469 · see citing works

Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program

Muruganandan, S., Roman, A. A., & Sinal, C. J. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8429-z · Cited by 457 · see citing works

Lrp5 functions in bone to regulate bone mass

Cui, Y., Niziolek, P., MacDonald, B. T., Diegel, C. R., Alenina, N. V., Robinson, D. R., Zhong, Z. A., Matthes, S., Jacobsen, C. M., Conlon, R. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2388 · Cited by 454 · see citing works

The Wnt Antagonist Secreted Frizzled-Related Protein-1 Is a Negative Regulator of Trabecular Bone Formation in Adult Mice

Bodine, P. V. N., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A.-J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B., & Komm, B. S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0498 · Cited by 450 · see citing works

Implant osseointegration and the role of microroughness and nanostructures: Lessons for spine implants

Gittens, R. A., Olivares‐Navarrete, R., Schwartz, Z., & Boyan, B. D. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.03.037 · Cited by 449 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

Lobov, I. B., Rao, S., Carroll, T. J., Vallance, J. E., Ito, M., Ondr, J. K., Kurup, S., Glass, D. A., Patel, M. S., Shu, W., et al. (2005) · Nature · doi:10.1038/nature03928 · Cited by 429 · see citing works

Macrophage Wnt7b is critical for kidney repair and regeneration

Lin, S., Li, B., Rao, S., Yeo, E.-J., Hudson, T. E., Nowlin, B. T., Pei, H., Chen, L., Zheng, J., Carroll, T. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912228107 · Cited by 424 · see citing works

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

Long, F., Chung, U., Ohba, S., McMahon, J. A., Kronenberg, H. M., & McMahon, A. P. (2004) · Development · doi:10.1242/dev.01006 · Cited by 423 · see citing works

Bone physiology as inspiration for tissue regenerative therapies

Lopes, D., Martins‐Cruz, C., Oliveira, M. B., & Mano, J. F. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.028 · Cited by 438 · see citing works

Marrow Fat and Bone—New Perspectives

Fazeli, P. K., Horowitz, M. C., MacDougald, O. A., Scheller, E. L., Rodeheffer, M. S., Rosen, C. J., & Klibanski, A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3634 · Cited by 417 · see citing works

Development and pathology of the hyaloid, choroidal and retinal vasculature

Saint‐Geniez, M., & D'Amore, P. A. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041895ms · Cited by 413 · see citing works

The gut-bone axis: How bacterial metabolites bridge the distance

Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403 · see citing works

Osteoporosis, inflammation and ageing

Ginaldi, L., Di Benedetto, M. C., & De Martinis, M. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-14 · Cited by 412 · see citing works

Bioinorganics and biomaterials: Bone repair

Habibovic, P., & Barralet, J. E. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.03.027 · Cited by 441 · see citing works

The role of Dickkopf-1 in bone development, homeostasis, and disease

Pinzone, J. J., Hall, B. M., Thudi, N. K., Vonau, M., Qiang, Y., Rosol, T. J., & Shaughnessy, J. D. (2008) · Blood · doi:10.1182/blood-2008-03-145169 · Cited by 408 · see citing works

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

Fulciniti, M., Tassone, P., Hideshima, T., Vallet, S., Nanjappa, P., Ettenberg, S. A., Shen, Z., Patel, N., Tai, Y., Chauhan, D., et al. (2009) · Blood · doi:10.1182/blood-2008-11-191577 · Cited by 400 · see citing works

Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ

Kang, S., Bennett, C. N., Gerin, I., Rapp, L. A., Hankenson, K. D., & MacDougald, O. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700030200 · Cited by 400 · see citing works

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Fujino, T., Asaba, H., Kang, M., Ikeda, Y., Sone, H., Takada, S., Kim, D.-H., Ioka, R. X., Ono, M., Tomoyori, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0133792100 · Cited by 399 · see citing works

The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment

Sawakami, K., Robling, A. G., Ai, M., Pitner, N. D., Liu, D., Warden, S. J., Li, J., Maye, P. F., Rowe, D. W., Duncan, R. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601000200 · Cited by 397 · see citing works

Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT

Almeida, M., Li, H., Bellido, T., Manolagas, S. C., & Kousteni, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502168200 · Cited by 394 · see citing works

Update on Wnt signaling in bone cell biology and bone disease

Monroe, D. G., McGee‐Lawrence, M. E., Oursler, M. J., & Westendorf, J. J. (2011) · Gene · doi:10.1016/j.gene.2011.10.044 · Cited by 388 · see citing works

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

O’Brien, C. A., Plotkin, L. I., Galli, C., Goellner, J. J., Gortázar, A. R., Allen, M. R., Robling, A. G., Bouxsein, M., Schipani, E., Turner, C. H., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002942 · Cited by 389 · see citing works

Genetics of Osteoporosis

Ralston, S. H., & Uitterlinden, A. G. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0044 · Cited by 384 · see citing works

Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q

Toomes, C., Bottomley, H. M., Jackson, R. M., Towns, K. V., Scott, S., Mackey, D. A., Craig, J. E., Jiang, L., Yang, Z., Trembath, R. C., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/383202 · Cited by 381 · see citing works

The Regulation of Differentiation in Mesenchymal Stem Cells

Augello, A., & Bari, C. D. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.173 · Cited by 370 · see citing works

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

Esen, E., Chen, J., Karner, C. M., Okunade, A. L., Patterson, B. W., & Long, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.017 · Cited by 367 · see citing works

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

Movérare‐Skrtic, S., Henning, P., Liu, X., Nagano, K., Saito, H., Börjesson, A., Sjögren, K., Windahl, S. H., Farman, H. H., Kindlund, B., et al. (2014) · Nature Medicine · doi:10.1038/nm.3654 · Cited by 364 · see citing works

Genetic regulation of bone mass and susceptibility to osteoporosisPreprint

Ralston, S. H., & Crombrugghe, B. D. (2006) · Genes & Development · doi:10.1101/gad.1449506 · Cited by 364 · see citing works

Bone Morphogenetic Proteins in Vascular Calcification

Hruska, K. A., Mathew, S., & Saab, G. (2005) · Circulation Research · doi:10.1161/01.res.00000175571.53833.6c · Cited by 361 · see citing works

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359 · see citing works

Wnt signaling in bone formation and its therapeutic potential for bone diseases

Kim, J. H., Liu, X., Wang, J., Chen, X. '., Zhang, H., Kim, S. H., Cui, J., Li, R., Zhang, W., Kong, Y., et al. (2013) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12466608 · Cited by 357 · see citing works

Calcineurin/NFAT Signaling in Osteoblasts Regulates Bone Mass

Winslow, M. M., Pan, M., Starbuck, M. W., Gallo, E. M., Deng, L., Karsenty, G., & Crabtree, G. R. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.006 · Cited by 354 · see citing works

Building bone to reverse osteoporosis and repair fractures

Khosla, S., Westendorf, J. J., & Oursler, M. J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33612 · Cited by 353 · see citing works

Canonical WNT signaling components in vascular development and barrier formation

Zhou, Y., Wang, Y., Tischfield, M. A., Williams, J., Smallwood, P. M., Rattner, A., Taketo, M. M., & Nathans, J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76431 · Cited by 348 · see citing works

The Regulation of Bone Metabolism and Disorders by Wnt Signaling

Maeda, K., Kobayashi, Y., Koide, M., Uehara, S., Okamoto, M., Ishihara, A., Kayama, T., Saito, M., & Marumo, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225525 · Cited by 353 · see citing works

Wnt signaling pathway: A comprehensive review

Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 356 · see citing works

Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity

Ellies, D. L., Viviano, B. L., McCarthy, J. J., Rey, J., Itasaki, N., Saunders, S., & Krumlauf, R. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060810 · Cited by 350 · see citing works

WNT Signaling in Cardiac and Vascular Disease

Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.013896 · Cited by 344 · see citing works

JCB Article

Chan, L. (2013)

LRP5: Structural and Molecular Aspects

Johnson, M. L. (2006) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1385/bmm:4:2:97 · Cited by 1 · see citing works

For healthy eyes and bones

Dove, A. W. (2002) · The Journal of Cell Biology · doi:10.1083/jcb1572iti3

The Role of Wnt Signaling in Bone and Mineral Metabolism

Bodine, P. V. N., Robinson, J. A., Bhat, R. A., Billiard, J., Bex, F. J., & Komm, B. S. (2006) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1385/bmm:4:2:73 · Cited by 9 · see citing works

Sfrp5 expression is reduced in placental junctional zone in pregnant rats fed a low protein diet

Gao, H., Tanchico, D., Yallampalli, U., & Yallampalli, C. (2014) · Placenta · doi:10.1016/j.placenta.2014.06.248 · Cited by 1 · see citing works