The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Negative feedback regulation of UV-B–induced photomorphogenesis and stress acclimation in Arabidopsis
Open accessAbstract
Plants respond to low levels of UV-B radiation with a coordinated photomorphogenic response that allows acclimation to this environmental stress factor. The key players in this UV-B response are COP1 (an E3 ubiquitin ligase), UVR8 (a β-propeller protein), and HY5 (a bZIP transcription factor). We have shown previously that an elevated UV-B–specific response is associated with dwarf growth, indicating the importance of balancing UV-B–specific signaling. Negative regulators of this pathway are not known, however. Here, we describe two highly related WD40-repeat proteins, REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1 (RUP1) and RUP2, that interact directly with UVR8 as potent repressors of UV-B signaling. Both genes were transcriptionally activated by UV-B in a COP1-, UVR8-, and HY5-dependent manner. rup1 rup2 double mutants showed an enhanced response to UV-B and elevated UV-B tolerance after acclimation. Overexpression of RUP2 resulted in reduced UV-B–induced photomorphogenesis and impaired acclimation, leading to hypersensitivity to UV-B stress. These results are consistent with an important regulatory role for RUP1 and RUP2, which act downstream of UVR8–COP1 in a negative feedback loop impinging on UVR8 function, balancing UV-B defense measures and plant growth.
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Cites
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Signal Transduction in Responses to UV-B Radiation
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Self-citationA UV-B-specific signaling component orchestrates plant UV protection
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Visualization of molecular interactions by fluorescence complementation
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Cited by
Native mass spectrometry reveals the conformational diversity of the UVR8 photoreceptor
Camacho, I. S., Theisen, A., Johannissen, L. O., Díaz-Ramos, L. A., Christie, J. M., Jenkins, G. I., Bellina, B., Barran, P., & Jones, A. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813254116 · Cited by 54
Metadata
- Authors
- Gruber, H., Heijde, M., Heller, W., Albert, A., Seidlitz, H. K., & Ulm, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-11
- Volume
- 107
- Issue
- 46
- Pages
- 20132-20137
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2092785935
- Cited by
- 263
- References
- 27
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Gruber, H., Heijde, M., Heller, W., Albert, A., Seidlitz, H. K., & Ulm, R. (2010). Negative feedback regulation of UV-B–induced photomorphogenesis and stress acclimation in Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0914532107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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