The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency
Open accessAbstract
Human populations use a variety of subsistence strategies to exploit an exceptionally broad range of ecoregions and dietary components. These aspects of human environments have changed dramatically during human evolution, giving rise to new selective pressures. To understand the genetic basis of human adaptations, we combine population genetics data with ecological information to detect variants that increased in frequency in response to new selective pressures. Our approach detects SNPs that show concordant differences in allele frequencies across populations with respect to specific aspects of the environment. Genic and especially nonsynonymous SNPs are overrepresented among those most strongly correlated with environmental variables. This provides genome-wide evidence for selection due to changes in ecoregion, diet, and subsistence. We find particularly strong signals associated with polar ecoregions, with foraging, and with a diet rich in roots and tubers. Interestingly, several of the strongest signals overlap with those implicated in energy metabolism phenotypes from genome-wide association studies, including SNPs influencing glucose levels and susceptibility to type 2 diabetes. Furthermore, several pathways, including those of starch and sucrose metabolism, are enriched for strong signals of adaptations to a diet rich in roots and tubers, whereas signals associated with polar ecoregions are overrepresented in genes associated with energy metabolism pathways.
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Finding the missing heritability of complex diseases
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Self-citationGenome-wide detection and characterization of positive selection in human populations
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Cited by
Using Environmental Correlations to Identify Loci Underlying Local Adaptation
Coop, G., Witonsky, D., Di Rienzo, A., & Pritchard, J. K. (2010) · Genetics · doi:10.1534/genetics.110.114819 · Cited by 709
Self-citationDetecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
Fumagalli, M., Sironi, M., Pozzoli, U., Ferrer-Admettla, A., Pattini, L., & Nielsen, R. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002355 · Cited by 600
A population genetic signal of polygenic adaptation
Berg, J. J., & Coop, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004412 · Cited by 487
Self-citationAdaptation–not by sweeps alone
Pritchard, J. K., & Di Rienzo, A. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2880 · Cited by 445
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Metadata
- Authors
- Hancock, A. M., Witonsky, D. B., Ehler, E., Alkorta-Aranburu, G., Beall, C., Gebremedhin, A., Sukernik, R., Utermann, G., Pritchard, J., Coop, G., & Di Rienzo, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-05-05
- Volume
- 107
- Issue
- supplement_2
- Pages
- 8924-8930
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1629867331
- Cited by
- 258
- References
- 46
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Hancock, A. M., Witonsky, D. B., Ehler, E., Alkorta-Aranburu, G., Beall, C., Gebremedhin, A., Sukernik, R., Utermann, G., Pritchard, J., Coop, G., & Di Rienzo, A. (2010). Human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0914625107
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