The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complete genome sequence of the Q-fever pathogen Coxiellaburnetii
Open accessAbstract
The 1,995,275-bp genome of Coxiella burnetii, Nine Mile phase I RSA493, a highly virulent zoonotic pathogen and category B bioterrorism agent, was sequenced by the random shotgun method. This bacterium is an obligate intracellular acidophile that is highly adapted for life within the eukaryotic phagolysosome. Genome analysis revealed many genes with potential roles in adhesion, invasion, intracellular trafficking, host-cell modulation, and detoxification. A previously uncharacterized 13-member family of ankyrin repeat-containing proteins is implicated in the pathogenesis of this organism. Although the lifestyle and parasitic strategies of C. burnetii resemble that of Rickettsiae and Chlamydiae, their genome architectures differ considerably in terms of presence of mobile elements, extent of genome reduction, metabolic capabilities, and transporter profiles. The presence of 83 pseudogenes displays an ongoing process of gene degradation. Unlike other obligate intracellular bacteria, 32 insertion sequences are found dispersed in the chromosome, indicating some plasticity in the C. burnetii genome. These analyses suggest that the obligate intracellular lifestyle of C. burnetii may be a relatively recent innovation.
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Cites
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Cited by
Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
Voth, D. E., & Heinzen, R. A. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00901.x · Cited by 11,767
Self-citationWu, M., Sun, L. V., Vamathevan, J., Riegler, M., Deboy, R., Brownlie, J. C., McGraw, E. A., Martin, W., Esser, C., Ahmadinejad, N., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020069 · Cited by 851
“The recently sequenced genomes of the intracellular pathogen Coxiella burnetti (Seshadri et al. 2003) has both a streamlined genome and moderate amounts of repetitive DNA, although much less than w Mel.”
InfluentialSelf-citationCazalet, C., Rusniok, C., Brüggemann, H., Zidane, N., Magnier, A., Ma, L., Tichit, M., Jarraud, S., Bouchier, C., Vandenesch, F., et al. (2004) · Nature Genetics · doi:10.1038/ng1447 · Cited by 655
The complete genome sequence of Francisella tularensis, the causative agent of tularemia
Larsson, P., Oyston, P. C. F., Chain, P., Chu, M. C., Duffield, M., Fuxelius, H.-H., Garcia, E., Hälltorp, G., Johansson, D., Isherwood, K. E., et al. (2005) · Nature Genetics · doi:10.1038/ng1499 · Cited by 455
Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors
Pan, X., Lührmann, A., Satoh, A., Laskowski-Arce, M. A., & Roy, C. R. (2008) · Science · doi:10.1126/science.1158160 · Cited by 388
Metadata
- Authors
- Seshadri, R., Paulsen, I. T., Eisen, J. A., Read, T. D., Nelson, K. E., Nelson, W. C., Ward, N. L., Tettelin, H., Davidsen, T. M., Beanan, M. J., Deboy, R. T., Daugherty, S. C., Brinkac, L. M., Madupu, R., Dodson, R. J., Khouri, H. M., Lee, K. H., Carty, H. A., Scanlan, D., Heinzen, R. A., Thompson, H. A., Samuel, J. E., Fraser, C. M., & Heidelberg, J. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-18
- Volume
- 100
- Issue
- 9
- Pages
- 5455-5460
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109336572
- Cited by
- 563
- References
- 1
- FWCI
- 21.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Seshadri, R., Paulsen, I. T., Eisen, J. A., Read, T. D., Nelson, K. E., Nelson, W. C., Ward, N. L., Tettelin, H., Davidsen, T. M., Beanan, M. J., Deboy, R. T., Daugherty, S. C., Brinkac, L. M., Madupu, R., Dodson, R. J., Khouri, H. M., Lee, K. H., Carty, H. A., Scanlan, D., . . . Heidelberg, J. F. (2003). Complete genome sequence of the Q-fever pathogen Coxiellaburnetii. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0931379100
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
