The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors
Open accessAbstract
Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila -containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.
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Cites
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BIOGENESIS, ARCHITECTURE, AND FUNCTION OF BACTERIAL TYPE IV SECRETION SYSTEMS
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The Genomic Sequence of the Accidental Pathogen Legionella pneumophila
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Cited by
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947
Biological Diversity of Prokaryotic Type IV Secretion Systems
Alvarez-Martinez, C. E., & Christie, P. J. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00023-09 · Cited by 729
Genomic insights into the marine sponge microbiome
Hentschel, U., Piel, J., Degnan, S. M., & Taylor, M. W. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2839 · Cited by 658
Molecular Pathogenesis of Infections Caused by Legionella pneumophila
Newton, H. J., Ang, D. K. Y., van Driel, I. R., & Hartland, E. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-09 · Cited by 494
The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation
Choy, A., Dancourt, J., Mugo, B., O’Connor, T. J., Isberg, R. R., Melia, T. J., & Roy, C. R. (2012) · Science · doi:10.1126/science.1227026 · Cited by 473
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Metadata
- Authors
- Pan, X., Lührmann, A., Satoh, A., Laskowski-Arce, M. A., & Roy, C. R.
- Venue
- Science
- Published
- 2008-06-20
- Volume
- 320
- Issue
- 5883
- Pages
- 1651-1654
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994475681
- Cited by
- 388
- References
- 19
- FWCI
- 20.79
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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