The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
Open accessAbstract
The influence of transforming growth factor β (TGF-β) signaling on Neu-induced mammary tumorigenesis and metastasis was examined with transgenic mouse models. We generated mice expressing an activated TGF-β type I receptor or dominant negative TGF-β type II receptor under control of the mouse mammary tumor virus promoter. When crossed with mice expressing activated forms of the Neu receptor tyrosine kinase that selectively couple to the Grb2 or Shc signaling pathways the activated type I receptor increased the latency of mammary tumor formation but also enhanced the frequency of extravascular lung metastasis. Conversely, expression of the dominant negative type II receptor decreased the latency of Neu-induced mammary tumor formation while significantly reducing the incidence of extravascular lung metastases. These observations argue that TGF-β can promote the formation of lung metastases while impairing Neu-induced tumor growth and suggest that extravasation of breast cancer cells from pulmonary vessels is a point of action of TGF-β in the metastatic process.
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Cites
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Cited by
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
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TGF-β signaling in health and disease
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Metadata
- Authors
- Siegel, P. M., Shu, W., Cardiff, R. D., Muller, W. J., & Massagué, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-06-13
- Volume
- 100
- Issue
- 14
- Pages
- 8430-8435
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2150091603
- Cited by
- 429
- References
- 39
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Siegel, P. M., Shu, W., Cardiff, R. D., Muller, W. J., & Massagué, J. (2003). Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0932636100
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
