The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The Mohawk homeobox gene is a critical regulator of tendon differentiation
Open accessAbstract
Mohawk ( Mkx ) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx −/− mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx −/− mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx −/− tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.
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Cites
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Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
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Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
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Structure of the tendon connective tissue
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Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
Schweitzer, R., Chyung, J. H., Murtaugh, L. C., Brent, A. E., Rosen, V., Olson, E. N., Lassar, A., & Tabin, C. J. (2001) · Development · doi:10.1242/dev.128.19.3855 · Cited by 859
Biology of tendon injury: healing, modeling and remodeling.
Sharma, P., & Maffulli, N. (2006) · PubMed · Cited by 837
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A Somitic Compartment of Tendon Progenitors
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Cited by
Transcription factor EGR1 directs tendon differentiation and promotes tendon repair
Guerquin, M.-J., Charvet, B., Nourissat, G., Havis, E., Ronsin, O., Bonnin, M.-A., Ruggiu, M., Olivera-Martinez, I., Robert, N., Lu, Y., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67521 · Cited by 259
Metadata
- Authors
- Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., Nishida, K., Akimoto, T., Takahashi, M., Miyaki, S., & Asahara, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-05-24
- Volume
- 107
- Issue
- 23
- Pages
- 10538-10542
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048892615
- Cited by
- 324
- References
- 31
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., Nishida, K., Akimoto, T., Takahashi, M., Miyaki, S., & Asahara, H. (2010). The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1000525107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
