The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Transcription factor EGR1 directs tendon differentiation and promotes tendon repair
Open accessAbstract
Tendon formation and repair rely on specific combinations of transcription factors, growth factors, and mechanical parameters that regulate the production and spatial organization of type I collagen. Here, we investigated the function of the zinc finger transcription factor EGR1 in tendon formation, healing, and repair using rodent animal models and mesenchymal stem cells (MSCs). Adult tendons of Egr1-/- mice displayed a deficiency in the expression of tendon genes, including Scx, Col1a1, and Col1a2, and were mechanically weaker compared with their WT littermates. EGR1 was recruited to the Col1a1 and Col2a1 promoters in postnatal mouse tendons in vivo. Egr1 was required for the normal gene response following tendon injury in a mouse model of Achilles tendon healing. Forced Egr1 expression programmed MSCs toward the tendon lineage and promoted the formation of in vitro-engineered tendons from MSCs. The application of EGR1-producing MSCs increased the formation of tendon-like tissues in a rat model of Achilles tendon injury. We provide evidence that the ability of EGR1 to promote tendon differentiation is partially mediated by TGF-β2. This study demonstrates EGR1 involvement in adult tendon formation, healing, and repair and identifies Egr1 as a putative target in tendon repair strategies.
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Cites
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
Caplan, A. I. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21200 · Cited by 1,956
Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,634
Bi, Y., Ehirchiou, D., Kilts, T. M., Inkson, C. A., Embree, M. C., Sonoyama, W., Li, L., Leet, A. I., Seo, B.-M., Zhang, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1630 · Cited by 1,486
KADLER, K. E., HOLMES, D. F., TROTTER, J. A., & CHAPMAN, J. A. (1996) · Biochemical Journal · doi:10.1042/bj3160001 · Cited by 1,449
Self-citationMechanisms involved in the therapeutic properties of mesenchymal stem cells
da Silva Meirelles, L., Fontes, A. M., Covas, D. T., & Caplan, A. I. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.002 · Cited by 1,436
Reznikoff, C. A., Brankow, D. W., & Heidelberger, C. (1973) · PubMed · Cited by 1,119
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
Schweitzer, R., Chyung, J. H., Murtaugh, L. C., Brent, A. E., Rosen, V., Olson, E. N., Lassar, A., & Tabin, C. J. (2001) · Development · doi:10.1242/dev.128.19.3855 · Cited by 859
Collagen self-assembly and the development of tendon mechanical properties
Silver, F. H., Freeman, J. W., & Seehra, G. P. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00135-0 · Cited by 645
Murchison, N. D., Price, B. A., Conner, D. A., Keene, D. R., Olson, E. N., Tabin, C. J., & Schweitzer, R. (2007) · Development · doi:10.1242/dev.001933 · Cited by 575
Collagen; ultrastructure and its relation to mechanical properties as a function of ageing
Diamant, J., Keller, A., Baer, E., Litt, M., & Arridge, R. G. C. (1972) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1972.0019 · Cited by 553
Cited by
Millar, N. L., Silbernagel, K. G., Thorborg, K., Kirwan, P. D., Galatz, L. M., Abrams, G. D., Murrell, G. A. C., McInnes, I. B., & Rodeo, S. A. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00234-1 · Cited by 801
Havis, E., & Duprez, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051664 · Cited by 494
Self-citationEGR-1 and DUSP-1 are important negative regulators of pro-allergic responses in airway epithelium
Golebski, K., van Egmond, D., de Groot, E. J., Roschmann, K. I. L., Fokkens, W. J., & van Drunen, C. M. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.12.011 · Cited by 22
Li, S., Wu, Y., Jiang, G., Tian, X., Hong, J., Chen, S., Yan, R., Feng, G., & Cheng, Z. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3006 · Cited by 20
Metadata
- Authors
- Guerquin, M.-J., Charvet, B., Nourissat, G., Havis, E., Ronsin, O., Bonnin, M.-A., Ruggiu, M., Olivera-Martinez, I., Robert, N., Lu, Y., Kadler, K. E., Baumberger, T., Doursounian, L., Berenbaum, F., & Duprez, D.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-07-25
- Volume
- 123
- Issue
- 8
- Pages
- 3564-3576
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1997782975
- Cited by
- 259
- References
- 59
- FWCI
- 16.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guerquin, M.-J., Charvet, B., Nourissat, G., Havis, E., Ronsin, O., Bonnin, M.-A., Ruggiu, M., Olivera-Martinez, I., Robert, N., Lu, Y., Kadler, K. E., Baumberger, T., Doursounian, L., Berenbaum, F., & Duprez, D. (2013). Transcription factor EGR1 directs tendon differentiation and promotes tendon repair. Journal of Clinical Investigation. https://doi.org/10.1172/jci67521
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