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NMDA receptors regulate GABA A receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit
Open accessAbstract
Modification of the number of GABA A receptors (GABA A Rs) clustered at inhibitory synapses can regulate inhibitory synapse strength with important implications for information processing and nervous system plasticity and pathology. Currently, however, the mechanisms that regulate the number of GABA A Rs at synapses remain poorly understood. By imaging superecliptic pHluorin tagged GABA A R subunits we show that synaptic GABA A R clusters are normally stable, but that increased neuronal activity upon glutamate receptor (GluR) activation results in their rapid and reversible dispersal. This dispersal correlates with increases in the mobility of single GABA A Rs within the clusters as determined using single-particle tracking of GABA A Rs labeled with quantum dots. GluR-dependent dispersal of GABA A R clusters requires Ca 2+ influx via NMDA receptors (NMDARs) and activation of the phosphatase calcineurin. Moreover, the dispersal of GABA A R clusters and increased mobility of individual GABA A Rs are dependent on serine 327 within the intracellular loop of the GABA A R γ2 subunit. Thus, NMDAR signaling, via calcineurin and a key GABA A R phosphorylation site, controls the stability of synaptic GABA A Rs, with important implications for activity-dependent control of synaptic inhibition and neuronal plasticity.
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“The surface mobility of neurotransmitter receptors is dynamically regulated to control synaptic activity and is emerging as another key component underlying plasticity at nerve terminals.40,53,54”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [40]
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Cites
Dynasore, a Cell-Permeable Inhibitor of Dynamin
Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., & Kirchhausen, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.002 · Cited by 1,958
Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking
Dahan, M., Lévi, S., Luccardini, C., Rostaing, P., Riveau, B., & Triller, A. (2003) · Science · doi:10.1126/science.1088525 · Cited by 1,465
Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses
MacAskill, A. F., Rinholm, J. E., Twelvetrees, A. E., Arancibia‐Cárcamo, I. L., Muir, J., Fransson, Å., Aspenström, P., Attwell, D., & Kittler, J. T. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.030 · Cited by 687
Self-citationLocally dynamic synaptic learning rules in pyramidal neuron dendrites
Harvey, C. D., & Svoboda, K. (2007) · Nature · doi:10.1038/nature06416 · Cited by 625
Compartmentalized dendritic plasticity and input feature storage in neurons
Losonczy, A., Makara, J. K., & Magee, J. C. (2008) · Nature · doi:10.1038/nature06725 · Cited by 598
Naylor, D. E., Liu, H., & Wasterlain, C. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4944-04.2005 · Cited by 558
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F. A., Lounis, B., & Choquet, D. (2004) · Nature Neuroscience · doi:10.1038/nn1270 · Cited by 463
Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy
Stelzer, A., Slater, N. T., & ten Bruggencate, G. (1987) · Nature · doi:10.1038/326698a0 · Cited by 388
Gating multiple signals through detailed balance of excitation and inhibition in spiking networks
Vogels, T. P., & Abbott, L. F. (2009) · Nature Neuroscience · doi:10.1038/nn.2276 · Cited by 375
Subunit-Specific Trafficking of GABAAReceptors during Status Epilepticus
Goodkin, H. P., Joshi, S., Mtchedlishvili, Z., Brar, J., & Kapur, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3426-07.2008 · Cited by 326
Kittler, J. T., Delmas, P., Jovanovic, J. N., Brown, D. A., Smart, T. G., & Moss, S. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07972.2000 · Cited by 314
Self-citationKittler, J. T., & Moss, S. J. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00064-3 · Cited by 301
Self-citationLong-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance
Gaïarsa, J., Caillard, O., & Ben‐Ari, Y. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02269-5 · Cited by 300
Gephyrin Regulates the Cell Surface Dynamics of Synaptic GABAAReceptors
Jacob, T. C., Bogdanov, Y. D., Magnus, C. J., Saliba, R. S., Kittler, J. T., Haydon, P. G., & Moss, S. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2267-05.2005 · Cited by 277
Self-citationLu, Y. M., Mansuy, I. M., Kandel, E. R., & Roder, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81150-2 · Cited by 276
Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin
Twelvetrees, A. E., Yuen, E. Y., Arancibia‐Cárcamo, I. L., MacAskill, A. F., Rostaing, P., Lumb, M. J., Humbert, S., Triller, A., Saudou, F., Yan, Z., et al. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.007 · Cited by 276
Self-citationActivity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics
Bannai, H., Lévi, S., Schweizer, C., Inoue, T., Launey, T., Racine, V., Sibarita, J., Mikoshiba, K., & Triller, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.023 · Cited by 270
New Concepts in Synaptic Biology Derived from Single-Molecule Imaging
Triller, A., & Choquet, D. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.022 · Cited by 262
Tretter, V., Jacob, T. C., Mukherjee, J., Fritschy, J., Pangalos, M., & Moss, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5050-07.2008 · Cited by 260
Control of Synaptic Strength, a Novel Function of Akt
Wang, Q., Liu, L., Pei, L., Ju, W. H., Ahmadian, G., Lu, J., Wang, Y., Liu, F., & Wang, Y. T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00356-8 · Cited by 258
Molecular Signaling Mechanisms Underlying Epileptogenesis
McNamara, J. O., Huang, Y. Z., & Leonard, A. S. (2006) · Science s STKE · doi:10.1126/stke.3562006re12 · Cited by 253
Moss, S. J., Doherty, C., & Huganir, R. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49736-6 · Cited by 250
Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis
Newton, A. J., Kirchhausen, T. L., & Murthy, V. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606212103 · Cited by 245
Kittler, J. T., Chen, G., Honing, S., Bogdanov, Y. D., McAinsh, K., Arancibia‐Cárcamo, I. L., Jovanovic, J. N., Pangalos, M. N., Haucke, V., Yan, Z., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506653102 · Cited by 192
Self-citationMarsden, K., Beattie, J. B., Friedenthal, J., & Carroll, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4433-07.2007 · Cited by 190
Dynamic mobility of functional GABAA receptors at inhibitory synapses
Thomas, P., Mortensen, M., Hosie, A. M., & Smart, T. G. (2005) · Nature Neuroscience · doi:10.1038/nn1483 · Cited by 183
Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts
Bogdanov, Y. D., Michels, G., Armstrong‐Gold, C. E., Haydon, P. G., Lindstrom, J. M., Pangalos, M. N., & Moss, S. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601309 · Cited by 181
Wang, J., Liu, S., Haditsch, U., Tu, W., Cochrane, K., Ahmadian, G., Tran, L., Paw, J., Wang, Y., Mansuy, I. M., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00826.2003 · Cited by 134
Kittler, J. T., Chen, G., Kukhtina, V., Vahedi‐Faridi, A., Gu, Z., Tretter, V. E., Smith, K. R., McAinsh, K., Arancibia‐Cárcamo, I. L., Saenger, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707920105 · Cited by 129
Self-citationHomeostatic Regulation of Synaptic GlyR Numbers Driven by Lateral Diffusion
Lévi, S., Schweizer, C., Bannai, H., Pascual, O., Charrier, C., & Triller, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.030 · Cited by 122
Activity-Dependent Movements of Postsynaptic Scaffolds at Inhibitory Synapses
Hanus, C., Ehrensperger, M.-V., & Triller, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5123-05.2006 · Cited by 105
Ubiquitin-dependent lysosomal targeting of GABA A receptors regulates neuronal inhibition
Arancibia‐Cárcamo, I. L., Yuen, E. Y., Muir, J., Lumb, M. J., Michels, G., Saliba, R. S., Smart, T. G., Yan, Z., Kittler, J. T., & Moss, S. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905502106 · Cited by 88
Self-citationRegulation of GABAA receptor membrane trafficking and synaptic localization
Arancibia‐Cárcamo, I. L., & Kittler, J. T. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.012 · Cited by 64
Self-citationTretter, V. E., Revilla-Sanchez, R., Houston, C. M., Terunuma, M., Havekes, R., Florian, C., Jurd, R., Vithlani, M., Michels, G., Couve, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908840106 · Cited by 60
Kannenberg, K., Sieghart, W., & REUTER, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00533.x · Cited by 48
Vithlani, M., & Moss, S. J. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371355 · Cited by 46
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Lüscher, B., Fuchs, T. A. E., & Kilpatrick, C. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.024 · Cited by 453
Gephyrin: a master regulator of neuronal function?
Tyagarajan, S. K., & Fritschy, J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3670 · Cited by 442
Pribiag, H., & Stellwagen, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0530-13.2013 · Cited by 260
Kullmann, D. M., Moreau, A. W., Bakiri, Y., & Nicholson, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.030 · Cited by 234
Metadata
- Authors
- Muir, J., Arancibia-Carcamo, I. L., MacAskill, A. F., Smith, K. R., Griffin, L. D., & Kittler, J. T.
- Affiliations
- University College London (GB)
- Department of Neuroscience, Physiology, and Pharmacology,
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-09-07
- Volume
- 107
- Issue
- 38
- Pages
- 16679-16684
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2944765
- OpenAlex
- W2090585744
- Cited by
- 158
- References
- 36
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 8 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 26 · 2013: 5 · 2012: 14
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- NMDA receptor, GABAA receptor, gamma2 subunit, receptor clustering, receptor lateral mobility, inhibitory synapses, synaptic inhibition, calcineurin, calcium influx, glutamate receptor activation, activity-dependent synaptic plasticity, receptor phosphorylation, single-particle tracking
- MeSH terms
- Animals, Cells, Cultured, Neuronal Plasticity, Neurons, Receptors, GABA-A, Recombinant Fusion Proteins, Serine, Synapses, Transfection, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Mutagenesis, Site-Directed, Glutamic Acid, Calcineurin, Amino Acid Substitution, Calcium Signaling, Multiprotein Complexes, Rats
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